[Evaluation of hepatic encephalopathy using computerized electroencephalography]. / Evaluación de la encefalopatía hepática mediante electroencefalografía computarizada.

Spectral EEG analysis techniques were used to evaluate the degree of hepatic encephalopathy in a group of 69 cirrhotic patients, as compared to the results obtained in a group of healthy controls. With respect to controls, the cirrhotics had stronger delta and theta bands, and a weaker alpha band, as well as a reaction of the alpha band to opening the eyes. The use of strength ratios between different bands of frequency increments the sensitivity and diagnostic reliability of this technique, particularly the delta/alpha and theta/alpha indices, and permits the detection of cases with subclinical encephalopathy, which is particularly useful for clinical follow-up and for the evaluation of different therapeutic regimens.

[Evaluation of the therapeutic effect of flumazenil in hepatic encephalopathy using cerebral cartography]. / Evaluación del efecto terapéutico del flumazenil en la encefalopatía hepática mediante cartografía cerebral.

We investigated the therapeutic effect of flumanezil on acute and chronic hepatic encephalopathy in a group of cirrhotics; its efficacy was evaluated using clinical data and neurophysiologic examination, e.g. brain mapping. Flumazenil was not found to induce significant changes in the clinical status or in maps of the cerebral activity of patients with chronic encephalopathy. In acute encephalopathy, flumazenil improved clinical status, as was confirmed neurophysiologically by improved cerebral activity on brain mapping.