Maternal Altitude-Corrected Hemoglobin and at Term Neonatal Anthropometry at 3400 m of Altitude.

Villamonte-Calanche, Wilfredo, Nelly Lam-Figueroa, Maria Jerí-Palomino, Cleto De-La-Torre, and Alexandra A. Villamonte-Jerí. Maternal altitude-corrected hemoglobin and at term neonatal anthropometry at 3400 m of altitude. High Alt Med Biol. 21:287-291, 2020. Introduction: Fetal growth is prominent in the last trimester of pregnancy. The development of the fetus depends on the nutrient consumption and oxygen delivery of the pregnant woman. Therefore, maternal anemia has an inverse relationship with fetal growth. Consequently, the newborn has lower anthropometric measurements. Residing in places of a high altitude increases the level of hemoglobin (Hb); as a result, the World Health Organization (WHO) recommends adjusting the value of Hb in maternal blood at 3400-m altitude by reducing 2.4 g/dL to obtain the corrected Hb (HbCorr). Objective: To determine if the relationship of maternal HbCorr for high altitude is related to term neonatal anthropometry at 3400-m altitude. Material and Methods: We performed a retrospective cohort study and evaluated the neonatal anthropometric variables (weight, ponderal index, head circumference [HC], and HC for birthweight index) in 308 exposed pregnant women (HbCorr <11 g/dL) and 600 unexposed pregnant women (HbCorr ≥11 g/dL). We obtained absolute relative frequencies and measures of central tendency. Besides, we compared the qualitative and quantitative variables using the chi-square and the Student t or the Mann-Whitney or Kruskal-Wallis U test, if applicable. We also performed linear regression. Results: Of anemic pregnant women, 68.2% were mild, while only 1% were severe. There was no relationship between HbCorr and neonatal anthropometry, and none of the anemic pregnant women showed a statistical difference in the neonatal anthropometric measures evaluated compared to the unexposed women. Conclusion: There is no relationship between HbCorr and neonatal anthropometry at 3400-m altitude.

Neonatal anthropometry at 3400 m above sea level compared with INTERGROWTH 21st standards.

OBJECTIVE: To determine the 3rd, 10th, 50th, 90th and 97th percentile of weight, length and head circumference (HC) of male and female neonates born at 3400 m above sea level and compare with published INTERGROWTH 21st standards. METHODS: Observational, transverse analytical study conducted in the National Hospital Adolfo Guevara Velazco of the ESSALUD hospital system in Cusco, Peru, at 3400 m altitude, during the period of January 2005 to December 2010. Using inclusion criteria, 7635 newborns were selected. The 3rd, 10th, 50th, 90th and 97th percentiles for the anthropometric measurements of birthweight, length and HC were determined for each sex and the results analyzed via polynomial regression for each percentile in order to compare the results with INTERGROWTH 21st standards. RESULTS: No statistically significant difference was observed with the exception of female HC at the 97th percentile when compared with the INTERGROWTH 21st standards. CONCLUSIONS: Based on tables generated in the present study, neonatal anthropometric percentiles at term at 3400 m above sea level demonstrate no appreciable difference with INTERGROWTH 21st standards with the exception of female HC at the 97th percentile.

Biometría fetal e Índice de líquido amniótico de 14 a 41 semanas a 3400 msnm y su comparación con tablas de otros niveles de altura fetal / Fetal biometry and amniotic fluid index from the 14th to the 41st week at 3400 meters altitude and comparing these parameters with those obtained at other altitude levels

Objetivos: Determinar tablas normales de biometría fetal e índice de líquido amniótico a 3400 m sobre el nivel del mar y su comparación con tablas de diferentes niveles de altura. Diseño: Estudio descriptivo prospectivo realizado por un sólo ecografista desde enero del 2007 a diciembre del 2010, en 1188 mujeres normales con gestaciones únicas en el Hospital Nacional Adolfo Guevara Velazco de EsSalud del Cusco. Resultados: Obtuvimos tablas con los percentiles 5 y 95 así como la media del diámetro biparietal, diámetro frontoccipital, circunferencia cefálica, circunferencia abdominal, longitud femoral e índice de líquido amniótico. Conclusiones: La biometría fetal se incrementa a través de la gestación a 3400 m sobre el nivel del mar y se muestra menor en los extremos del embarazo en relación a Londres, mientras que sigue la misma tendencia con relación a Lima pero en forma inversa y mayor durante toda la gestación respecto a Cerro de Pasco.

Objectives:To know normal biometry tables and amniotic fluid index at 3400 m above sea level by ultrasound and comparation with others tables from different levels of altitude. Design: Prospective and descriptive study performed by one ultrasonographer from January of 2007 to December of 2010. 1188 normal women with singleton pregnancies National Hospital Adolfo Guevara Velazco of EsSalud in Cusco. Results: We obtained tables with 5th and 95th centiles and median of fetal biometrical parameters from 14 to 41 weeks of gestational age of biparietal diameter, frontoccipital diameter, cephalic circumference, abdominal circumference, femur length and amniotic fluid index. Conclusions: The fetal biometry increases throughout the pregnancy at 3400 m above sea level. It shows lower at the end of pregnancy in relation to London, while following the same trend in relation to Lima but in reverse and increased throughout gestation in relationship to Cerro de Pasco.