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JAMA Neurol ; 74(5): 591-596, 2017 05 01.
Article in English | MEDLINE | ID: mdl-28264087

ABSTRACT

A 72-year-old woman developed new-onset depression, sustained an unexplained fall, and started walking cautiously. After 1 year, her depression resolved but she developed a dry cough. One year later, she experienced a more rapid decline in her gait with parkinsonism, visual difficulties with restricted vertical gaze, slowed horizontal and vertical saccades, dysphagia, apathy, and progressive cognitive decline, which led to her death 2 years later. The differential diagnosis, neuroimaging, and pathological findings are discussed, as well as their public health implications.


Subject(s)
Creutzfeldt-Jakob Syndrome/diagnosis , Prion Proteins/analysis , Aged , Creutzfeldt-Jakob Syndrome/physiopathology , Diagnosis, Differential , Fatal Outcome , Female , Humans
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