1.
J Med Chem
; 27(11): 1457-64, 1984 Nov.
Article
in English
| MEDLINE
| ID: mdl-6492075
ABSTRACT
A series of N,N'-polyalkylenebis[4-(substituted-amino)pyridines] has been prepared, and members have been evaluated as potential anti-dental plaque agents. From among the most active members of the series, one compound, N,N'-[1,10-decanediyldi-1(4H)-pyridinyl-4-ylidene]bis(1-octanam ine) dihydrochloride, octenidine, was selected as a candidate for clinical study.
Subject(s)
Aminopyridines/therapeutic use , Dental Plaque/drug therapy , Humans , Structure-Activity Relationship
2.
J Med Chem
; 17(7): 702-8, 1974 Jul.
Article
in English
| MEDLINE
| ID: mdl-4209582
Subject(s)
Amidines/chemical synthesis , Hypoglycemic Agents/chemical synthesis , Natriuresis/drug effects , Amidines/pharmacology , Amidines/toxicity , Animals , Blood Glucose/analysis , Blood Pressure/drug effects , Cats , Codeine , Dogs , Haplorhini , Hydrochlorothiazide/pharmacology , Hypertension, Renal/metabolism , Hypoglycemic Agents/pharmacology , Hypoglycemic Agents/toxicity , In Vitro Techniques , Kinetics , Lethal Dose 50 , Male , Mice , Microsomes, Liver/enzymology , Oxidoreductases, N-Demethylating/antagonists & inhibitors , Oximes/chemical synthesis , Oximes/pharmacology , Oximes/toxicity , Proadifen/pharmacology , Rats , Structure-Activity Relationship
3.
J Med Chem
; 16(2): 151-6, 1973 Feb.
Article
in English
| MEDLINE
| ID: mdl-4683110
