ABSTRACT
F.D. exhibited the cognitive and behavioral profile of frontotemporal dementia in the context of spontaneous intracranial hypotension (SIH). Symptoms included orthostatic headache, as well as cognitive and personality changes. He underwent CT, EEG, and MRI as well as neuropsychological evaluations before and after corticosteroid treatment. The initial evaluation documented significant cognitive impairment with a predominance of executive dysfunction. Following treatment, a second evaluation revealed marked improvement in cognition and behavior. Rapid diagnosis and treatment can yield a favorable outcome. Both quantitative and qualitative information from measures of executive functioning were discussed, as well as their anatomical substrates.
Subject(s)
Cognition Disorders/diagnosis , Dementia/diagnosis , Intracranial Hypotension/diagnosis , Adrenal Cortex Hormones/therapeutic use , Cognition Disorders/drug therapy , Cognition Disorders/etiology , Dementia/etiology , Dementia/physiopathology , Diagnosis, Differential , Frontal Lobe/pathology , Frontal Lobe/physiopathology , Humans , Intracranial Hypotension/complications , Intracranial Hypotension/physiopathology , Magnetic Resonance Imaging , Male , Middle Aged , Temporal Lobe/pathology , Temporal Lobe/physiopathologyABSTRACT
We describe the clinical history, histopathology and treatment of a two and a half year old boy. He presents with a chronic, unilateral and (pseudo) membranous conjunctivitis, preceded by ear-nose-throat problems and arthritis. The case was considered to be a ligneous conjunctivitis. Treatment consisted of repeated removal of the membranes, combined with topical hyaluronidase, alpha-chymotrypsin, cyclosporin, heparin and antibiotics, and was deceiving.
