Improving the health of Oklahomans through clinical prevention, part II: Screening to identify early-stage disease and risk factors.

The purpose of screening is to identify asymptomatic disease, or risk factors for disease, so that interventions can occur as early as possible in the disease process. The primary goal is to decrease the morbidity the patient experiences from the disease. For infectious diseases, screening can benefit not only the individual with the disease but also the community, since infectious persons can be identified and treated prior to transmitting the disease to others. Although screening can be very beneficial to the individual and to the community, it can also have adverse outcomes if not used appropriately. In this article we will discuss current recommendations for the use of screening tests and their role in addressing the leading causes of morbidity and mortality in Oklahoma. In general, physicians should consistently screen for the risk factors for cardiovascular disease and stroke (hypertension, high cholesterol, obesity and diabetes) and for early-stage cancers of the colon, breast, and cervix. They should also consider screening Native Americans for diabetes and persons at increased risk for certain infectious diseases, particularly sexually transmitted diseases.

Improving the health of Oklahomans through clinical prevention. Part 1: Counseling to decrease major risk factors.

Compared to other states, Oklahomans suffer higher levels of morbidity and mortality from several common conditions--coronary heart disease, chronic lung disease, stroke and injury. Unhealthy personal behaviors contribute significantly to each of these conditions, thus rendering them at least partially preventable by changing those behaviors. Research has shown that many patients will modify unhealthy behaviors as a result of services provided by physicians or staff in their offices, often with briefly delivered messages. In this report we will discuss the most common preventable illnesses suffered by Oklahomans and the risk factors associated with those illnesses. Physicians should make maximum use of their ability to promote healthy behaviors by their patients, with emphasis on the risk factors associated with significant morbidity in the state. They should also focus on those risk factors patients are likely to change following physician counseling, as determined by prevention research and described in the U.S. Preventive Services Task Force document Guide to Clinical Preventive Services. In general, physicians should consistently deliver messages that address tobacco products, alcohol and other drugs, the use of seat belts, and diet and exercise. Also, they should recommend that all women of childbearing age who are capable of becoming pregnant take a multivitamin containing folic acid daily.

Vegan diet-based lifestyle program rapidly lowers homocysteine levels.

BACKGROUND: Plasma homocysteine levels have been directly associated with cardiac disease risk. Current research raises concerns as to whether comprehensive lifestyle approaches including a plant-based diet may interact with other known modulators of homocysteine levels. METHODS: We report our observations of homocysteine levels in 40 self-selected subjects who participated in a vegan diet-based lifestyle program. Each subject attended a residential lifestyle change program at the Lifestyle Center of America in Sulphur, Oklahoma and had fasting plasma total homocysteine measured on enrollment and then after 1 week of lifestyle intervention. The intervention included a vegan diet, moderate physical exercise, stress management and spirituality enhancement sessions, group support, and exclusion of tobacco, alcohol, and caffeine. B vitamin supplements known to reduce blood homocysteine levels were not provided. RESULTS: Subjects' mean homocysteine levels fell 13%: from 8.66 micromol/L (SD 2.7 micromol/L) to 7.53 micromol/L (SD 2.12 micromol/L; P < 0.0001). Subgroup analysis showed that homocysteine decreased across a range of demographic and diagnostic categories. Conclusions. Our results suggest that broad-based lifestyle interventions favorably impact homocysteine levels. Furthermore, analysis of Lifestyle Center of America program components suggests that other factors in addition to B vitamin intake may be involved in the observed homocysteine lowering.

Improving the health of Oklahomans through clinical prevention, Part III: Immunizations and chemoprophylaxis.

Vaccines are one of the greatest achievements of biomedical science and public health and are clearly one of the most effective tools of clinical prevention. Diseases that once caused significant morbidity and mortality in Americans--particularly children--have been virtually eliminated from the population through effective immunization programs. But until these diseases have been eradicated globally we must continue to maintain high immunization levels to prevent their return; a 90% coverage rate has been set as the national goal for recommended vaccines in preschool age children. In Oklahoma we have only achieved that goal for two vaccines (measles and polio) and for the last several years we have ranked near the bottom in vaccine coverage rates compared to other states. Although achieving high vaccination rates in children involves numerous partners, private physicians must play a major role in that effort since they are the primary vaccine providers in the state. Physicians should also be alert to the vaccine needs of their adolescent and adult patients, particularly for pneumococcal disease, influenza, hepatitis A and B, and tetanus. This article describes current vaccination levels in Oklahoma children and adults for several routine and newly recommended vaccines and discusses the role of private physicians in maintaining and improving immunization coverage.

The epidemiology of left-handedness in a hospital population.

PURPOSE: We evaluated the association between left-handedness (LH) and age, education, cigarette smoking, alcohol consumption, and disease status in a case-control study of 8801 hospitalized patients with cancer and those with other conditions. METHODS: Subjects were interviewed in person using a structured questionnaire that contained detailed sections of lifestyle behaviors. RESULTS: The overall prevalences of LH were 7.6% among men and 6.5% among women. Among both sexes LH declined with increasing age (P < 0.05). After adjustment for age, the following associations were observed. Men had a higher risk of LH than women. The prevalence of LH was lower in ever-married subjects compared with never-married subjects (odds ratio [OR] for men, 0.7; 95% confidence intervals [CI], 0.5-0.9; for women, OR, 0.5; 95% CI, 0.3-0.9). Among men, the prevalence of LH was not associated with race, years of education, smoking status, or levels of alcohol consumption. The risk of LH was elevated in men diagnosed with fractures as compared with all other male patients (OR, 2.4; 95% CI, 1.3-6.7). Among women, LH was not associated with race, smoking, or hormonal and reproductive factors, but LH was more common among female high-school and college graduates and among self-reported alcoholics. The odds ratio of LH was significantly lower in women with breast cancer (OR, 0.3; 95% CI, 0.1-0.7). CONCLUSIONS: The increased risk of serious injuries in LH is not a result of higher alcohol use. Handedness might be an important factor in the safe use of industrial equipment.