Precision Health: Bringing Oral Health into the Context of Overall Health.

Unprecedented advances in genomics, data science, and biotechnology have ushered in a new era of health care in which interventions are increasingly tailored to individual patients. Precision-based approaches extend to oral health, which is essential to overall health. Harnessing the full potential of precision oral health will depend on research to more fully understand the factors that underlie health and contribute to disease-including the human genome, microbiome, epigenome, proteome, and others.

Prolonged Cold Ischemia Time Results in Local and Remote Organ Dysfunction in a Murine Model of Vascularized Composite Transplantation.

Vascularized composite allotransplantation (VCA) is a viable reconstructive option for complex tissue defects. Although grafts with a large muscular component may be uniquely susceptible to ischemia-reperfusion (I/R) syndrome, the safe cold ischemia time in VCA has not been established. We investigated the effects of cold ischemia on innate immune response and recipient survival in a murine orthotopic hindlimb transplantation model. Surprisingly, mice receiving grafts exposed to 6 h or longer of cold storage demonstrated reduced survival and massive elevations in serum creatinine, blood urea nitrogen, and creatine kinase, compared with 1 h of cold storage recipients. This was accompanied by progressive increase in macrophage and neutrophil cell infiltration in muscle biopsy specimens, altered platelet endothelial cell adhesion molecule-1 expression, and ultimate renal injury. Multiplex immunoassay analysis identified 21 cytokines in serum and 18 cytokines in muscle biopsy specimens that are likely essential in the complex response to I/R-triggered injury in VCA. In conclusion, this study, in a mouse model of orthotopic hindlimb transplantation, is the first to document that prolonged cold ischemia triggers progressive I/R injury with vascular endothelial damage and may lead to irrecoverable local and remote organ damage. These experimental findings are important in guiding future therapies for human VCA recipients.

Pathologic detection of occult metastases in regional lymph nodes in patients with head and neck cancer.

Squamous carcinomas of the head and neck region are exceedingly common problems in the routine practice of head and neck tumour surgery. Well-defined treatment protocols have evolved to manage patients afflicted with such tumours. This article explores the role of the hospital pathologist in the detection of occult metastases. The conventional approach to evaluation of cervical nodes from a neck dissection is reviewed, and then the potential utility of more recently developed diagnostic approaches (such as immunohistochemistry and polymerase chain reaction) is explored.

The pathology of neck dissection in cancer of the larynx.

Cancer of the larynx is a common problem in a head and neck oncological surgical practice; as such, pathology departments supporting such surgical practices will examine cervical lymph node dissection specimens with some frequency. Issues to be settled among pathologists and surgeons include--How precise an anatomic dissection of the specimen is called for? What histological features of the specimen will be of most use to the clinicians who are devising a course of postoperative therapy for the patient? What sorts of methods are needed to identify the maximum number of micrometastases which may be lurking within the lymph nodes of the specimen? Is there a role for routine application of special techniques--such as immunohistochemistry or molecular biology--in the analysis of these specimens? While the answers to these questions are likely to vary somewhat from one center to another, patients are best served when these questions are discussed amongst the respective physicians before surgical procedures are undertaken, rather than after the fact.

Impact of phenotype on treatment and prognosis of laryngeal malignancies.

An overview of the impact of the phenotype on treatment and prognosis of different laryngeal malignancies is presented.

Pregnancy and malignant neoplasms of the head and neck.

This paper, based on a literature review, deals with the occasional development of a head and neck neoplasm in the pregnant woman. This rare event makes for some challenging problems in patient management, insofar as the otolaryngologist is actually responsible for taking care of 2 patients -- the mother and her unborn child. In particular, 4 tumor types have figured prominently among those head and neck tumors arising in pregnant women: cancer of the larynx, cancer of the thyroid, malignant melanomas, and malignant lymphomas of the head and neck. Of these, the most common appear to be melanomas, followed by lymphomas, thyroid carcinomas, and, finally, laryngeal carcinomas. The thyroid tumors, lymphomas, and laryngeal carcinomas do not appear to behave more aggressively in pregnant than in nonpregnant patients; there is, however, some anecdotal evidence to suggest that melanomas in pregnant women may be more aggressive neoplasms than similar-stage tumors in nonpregnant women. One difficulty in treating any of these tumor types in this clinical setting is the limitation that may be imposed on the use of adjuvant therapy by the presence of the unborn child, which may put the attending physicians in the difficult position of balancing less aggressive therapy for the mother against the potential for harming the baby through use of toxic systemic therapy.

Wegener's granulomatosis of the head and neck.

Among the more puzzling non-neoplastic necrotizing lesions of the head and neck area is Wegener's granulomatosis. This is a condition of unknown cause that may present (in the head and neck area) with ulceration of the nasal septum, sinus mucosa, oral mucosa, or external ear canal, or even destruction of the vocal cord. Diagnosis depends on the pathologic finding of a characteristic inflammatory reaction pattern (which, in its best-developed form, includes necrosis, granulomatous inflammation, and vasculitis) and the serum finding of an elevated antinuclear cytoplasmic antigen. Treatment is principally medical, with the use of powerful immunosuppressive agents. Distinction from other conditions that may mimic Wegener's granulomatosis (such as malignant lymphoma and infections) is of critical importance in constructing an appropriate treatment strategy.

Functional status of the oldest-old in a home setting.

The purpose of this cross-sectional study was to examine six domains of functioning: physical, mental, social, spiritual, economic and activities of daily living. The primary inclusion criteria at the time of recruitment were that participants be over the age of 85, be cognitively intact, and be living in a home setting. Instruments used for the study included the Older Americans Resource Survey (OARS), Mini-Mental Status Examination (MMSE), Geriatric Depression Scale (GDS), Spiritual Well Being Scale (SWBS). Fifty subjects, mean age 89 years, lived alone (65%) or with their spouse (22%) in their homes. Person's correlation analysis found significant relationships among physical, mental, social, economic and activities of daily living. Good to excellent functioning was found in the mental (82%) and social (82%) domains. Highest functional impairments were identified with ability to carry out activities of daily living (72%) and in the domains of physical functioning (55%). Common chronic illnesses reported were arthritis (56%), hypertension (46%) and cardiac problems (30%). The average daily use of prescribed drugs was three times and over-the-counter use was once per day. Eleven per cent of subjects were mildly (7%) or moderately (4%) depressed. Subjects reported that they needed visiting nurses (29%), home health aids (20%) and help with shopping (24%) and transportation (24%). The data suggest that multidimensional assessment is necessary to identify nursing interventions that will regain, maintain or enhance functioning among oldest-old people.

Health education via interactive television.

Providing health education in rural areas is a challenge because of the time and cost involved in travel to serve small groups of clients in their own towns. Baccalaureate nursing students provided health education to faculty and staff members in five rural high schools simultaneously through the use of interactive television.

Comparative effects of exercise reduction and relaxation training on mood states and Type A scores in habitual aerobic exercisers.

The comparative effects of exercise reduction and relaxation training on dysphoric mood states and Type A scores in persons who exercise beyond the American College of Sports Medicine's recommended guidelines for cardiovascular fitness were investigated. Using their scores on the Profile of Mood States and the Jenkins Activity Survey, 57 subjects were randomly divided into 3 matched groups based on age, gender, and exercise regimen. Subjects assigned to the control group maintained their current exercise regimen, those in the second group reduced their exercise regimen to include no more than 5 hours of aerobic activity per week, and those in the third group maintained their current exercise regimen and attended 5 1 1/2-hr. relaxation training sessions. Both inventories were administered again after 10 weeks. Multivariate analysis of covariance showed no statistically significant differences among group means on the dependent variables. Further research on the use of aerobic exercise and relaxation training as auxiliary treatments for anxiety and depression is recommended.

Nursing care for the relinquishing mother.

Unmarried adolescents with unplanned pregnancies face, along with the usual physiologic and psychologic changes, parental force and/or peer pressure to leave home and live elsewhere and a decision about the relinquishment of the infant. An important figure during the parental and immediate postpartum periods is the nurse. Nursing care required by relinquishing mothers is outlined and recommendations are given.