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Linezolid-Associated Thrombocytopenia in Children With Renal Impairment.

Jones, Sara J; Nichols, Kristen R; DeYoung, Heather L; Cox, Elaine G; Knoderer, Chad A.

J Pediatric Infect Dis Soc ; 4(3): 272-5, 2015 Sep.

Article in English | MEDLINE | ID: mdl-26407433

ABSTRACT

Impaired renal function has been associated with an increased risk of thrombocytopenia in adults receiving linezolid. Findings from this retrospective cohort demonstrate an association between thrombocytopenia and lower creatinine clearance in children receiving linezolid.

Subject(s)

Anti-Bacterial Agents/adverse effects , Creatinine/blood , Linezolid/adverse effects , Renal Insufficiency/chemically induced , Thrombocytopenia/chemically induced , Adolescent , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/pharmacokinetics , Child , Child, Preschool , Cohort Studies , Female , Humans , Infant , Linezolid/administration & dosage , Linezolid/pharmacokinetics , Male , Platelet Count , Retrospective Studies

ABSTRACT

Subject(s)

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