ABSTRACT
The major immunoglobulin classes were surveyed among 23 patients with carcinoma of the prostate, 14 patients with clinically manifest benign prostatic hyperplasia and 23 healthy, elderly men without evidence of prostatic disease to determine if differences in immunoglobulin levels existed. Levels of IgG,IgA and IgM were determined by single radial immunodiffusion. Serum IgM levels were depressed in patients with all stages of carcinoma of the prostate as compared to levels in controls. These depressions were significant statistically for the tumor group considered as a whole and for patients with stages A and B tumors; the depression of IgM levels in patients with stages C and D tumors bordered on statistical significance. Serum IgG levels were depressed significantly in patients with stages A and B carcinoma of the prostate as compared to controls. Levels in patients with stages C and D lesions exceeded control levels but the difference was not statistically significant. Serum IgA levels in patients with stages A and B tumors were comparable to control levels but levels in patients with stages C and D lesions were significantly higher than controls.
Subject(s)
Carcinoma/immunology , Immunoglobulins/analysis , Prostate/immunology , Prostatic Hyperplasia/immunology , Prostatic Neoplasms/immunology , Adult , Carcinoma/pathology , Humans , Immunoglobulin A/analysis , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Male , Neoplasm Staging , Prostate/pathology , Prostatic Hyperplasia/pathology , Prostatic Neoplasms/pathologyABSTRACT
The basic principles of vascular surgery, adequate exposure, proximal and distal control of hemorrhage, and meticulous approximation of endothelial surfaces should be adhered to in the management of lesions of the dural venous sinuses. Modification of conventional vascular techniques must be made since the major dural venous sinuses are essentially non collapsible and non mobilizable because of the entry of cortical veins at frequent intervals along their course. These problems can be solved by occlusion of the proximal and distal segments of the sinus from within the lumen and by use of a shunt consisting of a siliconized non-collapsible tube with an inflatable balloon cuff at each end. Saphenous vein autografts are used if primary repair is impossible because of loss of tissue. Using these techniques, a patency rate of 91% and a mortality rate of 9% were achieved in eleven cases involving the posterior sagittal and transverse sinuses.
Subject(s)
Brain Injuries/surgery , Cranial Sinuses/surgery , Humans , Methods , Saphenous Vein/transplantation , Transplantation, AutologousSubject(s)
Genitalia, Male/microbiology , Simplexvirus/isolation & purification , Adolescent , Adult , Aged , Cells, Cultured , Fluorescent Antibody Technique , Genital Diseases, Male/microbiology , Humans , Male , Middle Aged , Neutralization Tests , Penis/microbiology , Prostate/microbiology , Simplexvirus/pathogenicity , Testis/microbiology , Urethra/microbiology , Urologic Diseases/microbiology , Vas Deferens/microbiologyABSTRACT
Herpesvirus particles were found in cancer cells from a human prostate adenocarcinoma. These particles were identified as herpesvirus on the basis of specific immunofluorescence staining, morphology, and size.
Subject(s)
Adenocarcinoma/microbiology , Herpesviridae/isolation & purification , Prostatic Neoplasms/microbiology , Adenocarcinoma/etiology , Aged , Antigens, Viral/analysis , Cell Nucleus/microbiology , Culture Techniques , Cytopathogenic Effect, Viral , Fluorescent Antibody Technique , Herpesviridae/immunology , Humans , Kidney/embryology , Male , Microscopy, Electron , Prostate/microbiology , Prostatic Neoplasms/etiology , Virus CultivationABSTRACT
A population study of 190 randomly selected male patients with no history of genital herpesvirus infection revealed a high incidence of herpesvirus type 2 in genitourinary specimens. This indicates that men serve as a reservoir of genital herpesvirus.
