ABSTRACT
A novel binuclear squire planar complex of nalidixic acid with Ag(I) metal ion with the formula [Ag(Nal)2] has been synthesized. The synthesized metal complex was characterized using CHN analysis, Fourier-transformed infra-red (FT-IR), thermo gravimetric analysis (TGA), differential scanning calorimetry (DSC), ultra violet-visible (Uv-vis) and single-crystal X-ray diffraction (XRD). The newly synthesized complex shows more advanced antifungal activity compared to the parent quinolone against four fungi, namely Pythium aphanidermatum, Sclerotinia rolfsii, Rhizoctonia solani and Rhizoctonia bataticola.
Subject(s)
Antifungal Agents/chemistry , Antifungal Agents/pharmacology , Metals/chemistry , Nalidixic Acid/chemistry , Quinolones/chemistry , Antifungal Agents/chemical synthesis , Fungi/drug effects , Metals/pharmacology , Microbial Sensitivity Tests , Nalidixic Acid/pharmacology , Quinolones/pharmacology , Structure-Activity RelationshipABSTRACT
A novel slightly distorted octahedral complex of Cr(III) of norfloxacin (Nor) with the formula [Cr(III)(Nor)(Bipy)Cl2]Cl·2CH3OH has been synthesized hydrothermally in the presence of a N-containing heterocyclic compound 2,2'-bipyridyl (Bipy). The complex was characterized with FT-IR, elemental analysis, UV-visible spectroscopy, and X-ray crystallography. Spectral studies suggest that the Nor acts as a deprotonated bidentate ligand. Thermal studies were also carried out. The synthesised complex was screened against four fungi Pythium aphanidermatum (PA), Sclerotinia rolfsii (SR), Rhizoctonia solani (RS), and Rhizoctonia bataticola (RB).
