ABSTRACT
Clinical, histological and immunohistochemical data on 71 parotid gland tumors were analyzed. Benign neoplasms accounted for 71.8% of the case material and malignant tumors 22.6%. Chronic parotitis occurred in 5.6% of the total case number. Pleomorphic adenomas and mucoepidermoid carcinomas were the most frequently occurring benign and malignant neoplasms. Pleomorphic adenomas stained positive for S-100 protein, tenascin, smooth muscle actin, synaptophysin and chromogranin A. This immunohistochemical, histological and clinical analysis was believed to be of potential assistance in the diagnosis, treatment and prognosis of parotid gland tumors.
Subject(s)
Parotid Neoplasms/pathology , Actins/analysis , Adenoma, Pleomorphic/metabolism , Adenoma, Pleomorphic/pathology , Antigens, Neoplasm/analysis , Carcinoma, Mucoepidermoid/metabolism , Carcinoma, Mucoepidermoid/pathology , Chromogranin A , Chromogranins/analysis , Chronic Disease , Desmin/analysis , Glycoproteins/analysis , Humans , Immunoglobulin A, Secretory/analysis , Immunohistochemistry , Keratins/analysis , Parotid Neoplasms/diagnosis , Parotid Neoplasms/metabolism , Parotid Neoplasms/therapy , Parotitis/metabolism , Parotitis/pathology , Prognosis , S100 Proteins/analysis , Secretory Component/analysis , Synaptophysin/analysis , Tenascin/analysis , Tumor Suppressor Protein p53/analysisABSTRACT
The authors presented material of 52 parapharyngeal space tumors seen ENT Department Medical University of Gdansk in year 1980-1994. Majority of these tumors -32 (61.5%)-were benign (adenoma pleomorphum-22, adenolymphoma-4, neurilemmoma-4, ganglioneuroma-2). The remaining 20 (38.5%) tumors were malignant (cystis branchiogenes carcinomatosa-4, carcinoma planoepitheliale-3, lymphoma malignum-3, adenoma pleomorphum maligum-2, tumor mucoepidermalis-2, and tumor acinocellularis, chemodectoma, meningeoma malignum, haemangiopericytoma, chordoma, chondrosarcoma one of each.
Subject(s)
Pharyngeal Neoplasms/pathology , Adenolymphoma/pathology , Adenoma/pathology , Adult , Carcinoma/pathology , Female , Ganglioneuroma/pathology , Humans , Lymphoma/pathology , Male , Neurilemmoma/pathology , Sarcoma/pathologyABSTRACT
The authors presented 72 cases of malignant parotid gland tumors treated in ENT Dept. in Medical University of Gdansk in years 1970-1990. The most frequent tumors were: carcinoma planoepitheliale, adenocarcinoma et carcinoma muco-epidermale. Particular analysis of TNM stage, histopathological findings and therapy of described cases may be helpful in improving the treatment results.
