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Formulation and In Vitro Evaluation of Alendronate Sodium/PLGA Microspheres for Applications in Bone Related Disorders.

Deca, A G; Belu, I; Croitoru, O; Bubulica, M V; Manda, C V; Neamtu, J.

Curr Health Sci J ; 41(3): 246-250, 2015.

Article in English | MEDLINE | ID: mdl-30538826

ABSTRACT

Purpose - Bisphosphonates are a group of drugs that can be used in the development of new therapies for bone disorders. Microencapsulation by solvent evaporation is a method that results in microspheres with controlled release of the drug. The purpose of the present study was to include sodium alendronate (AL) in poly (lactic-co-glycolic acid) (PLGA) microspheres with a good encapsulation rate. Furthermore it was intended to obtain a prolonged release of the drug over a period of time. Material and methods - Microspheres were prepared by water/oil/water solvent evaporation method. The microspheres were characterized by FTIR analysis using an Avatar Nicolet spectrophotometer. Both encapsulation ratio and in vitro drug release were assessed by chromatographic analysis. Results - The method chosen for sodium alendronate incorporation resulted in microspheres with a good entrapment efficiency. The in vitro drug release from PLGA/AL microspheres was maintained up to 21 days. This suggests that the microspheres had a sustained releasing tendency. Conclusion - Given the prolonged release, PLGA/AL microspheres may be used in a controlled release system with applications in bone disease treatment.

[Endoscopic indications and therapy at the Craiova District Hospital over a 5-year period (1980-1984)]. / Aspecte de indicatii si terapie endoscopica la nivelul Spitalului Judetean Craiova pe o perioada de 5 ani (1980-1984).

Obreja, S; Grigorescu, G; Boiko, V; Mîtu, M; Mustata, E; Deca, A; Popescu, L; Pacuraru, T.

Rev Chir Oncol Radiol O R L Oftalmol Stomatol Otorinolaringol ; 33(2): 89-94, 1988.

Article in Romanian | MEDLINE | ID: mdl-2973100

Subject(s)

Bronchoscopy/statistics & numerical data , Esophagoscopy/statistics & numerical data , Hospitals, District , Hospitals, Public , Laryngoscopy/statistics & numerical data , Digestive System , Female , Foreign Bodies/diagnosis , Foreign Bodies/therapy , Humans , Male , Otorhinolaryngologic Diseases/diagnosis , Otorhinolaryngologic Diseases/therapy , Respiratory System , Romania

[Lessons learned from the care of patients with unusual intracavitary foreign bodies]. / Invataminte desprinse din îngrijirea unor corpi straini cavitari inediti.

Obreja, S; Grigorescu, G; Deca, A; Popescu, L; Mustata, E; Camenita, A.

Rev Chir Oncol Radiol O R L Oftalmol Stomatol Otorinolaringol ; 32(4): 271-9, 1987.

Article in Romanian | MEDLINE | ID: mdl-2964706

Subject(s)

Colon/diagnostic imaging , Ear , Foreign Bodies/diagnosis , Nasal Cavity , Brain Diseases/etiology , Bronchography , Ear/surgery , Eye Foreign Bodies/complications , Eye Foreign Bodies/diagnosis , Facial Paralysis/etiology , Female , Foreign Bodies/complications , Foreign Bodies/therapy , Humans , Infant , Male , Middle Aged , Mucocele/etiology

[Some diagnostic and therapeutic aspects of acute respiratory insufficiency in children]. / Unele aspecte de diagnostic si terapeutica în insuficienta acuta respiratorie a copilului.

Obreja, S; Popescu, L; Deca, A; Farcas, I; Teodorescu, I; Mihailescu, M.

Rev Chir Oncol Radiol O R L Oftalmol Stomatol Otorinolaringol ; 22(3): 207-12, 1977.

Article in Romanian | MEDLINE | ID: mdl-144940

Subject(s)

Endoscopy/adverse effects , Respiratory Insufficiency , Acute Disease , Bronchoscopy/adverse effects , Child , Child, Preschool , Foreign Bodies/complications , Foreign Bodies/diagnosis , Humans , Infant , Lung Neoplasms/complications , Lung Neoplasms/diagnosis , Pulmonary Edema/complications , Respiratory Insufficiency/etiology , Respiratory Insufficiency/therapy , Respiratory System

[A case of congenital hypoplasia of the internal carotid artery]. / Asupra unui caz de hipoplazie congenitala a arterei carotide interne

Lascu, O; Neacsu, R; Deca, A; Trusca, E.

Rev Med Interna Neurol Psihiatr Neurochir Dermatovenerol Neurol Psihiatr Neurochir ; 21(2): 107-11, 1976.

Article in Romanian | MEDLINE | ID: mdl-1085972

Subject(s)

Carotid Artery, Internal/abnormalities , Adult , Female , Humans , Ischemic Attack, Transient/etiology

[A case of congenital hypoplasia of the internal carotid artery]. / Asupra unui caz de hipoplazie congenitala a arterei carotide interne

Lascu, O; Neacsu, R; Deca, A; Trusca, E.

Rev Med Interna Neurol Psihiatr Neurochir Dermatovenerol Neurol Psihiatr Neurochir ; 20(3): 215-20, 1975.

Article in Romanian | MEDLINE | ID: mdl-1085468

Subject(s)

Carotid Artery, Internal/abnormalities , Cerebrovascular Disorders/congenital , Adult , Female , Humans

[Congenital lipoma of the pharynx in the newborn]. / Lipom congenital al faringelui la un nou-nascut.

Deca, A.

Otorinolaringologie ; 16(4): 353-6, 1971.

Article in Romanian | MEDLINE | ID: mdl-5140593

Subject(s)

Infant, Newborn, Diseases , Lipoma/congenital , Pharyngeal Neoplasms/congenital , Humans , Infant, Newborn , Male

[Experimental data on the cortical projection of nystagmus]. / Date experimentale în legatura cu proiectia corticala a nistagmusului.

Deca, A; Deca, A.

Otorinolaringologie ; 16(1): 27-34, 1971.

Article in Romanian | MEDLINE | ID: mdl-5313769

Subject(s)

Cerebral Cortex/physiology , Nystagmus, Pathologic , Vestibular Nerve/physiology , Vestibule, Labyrinth/physiology , Animals , Cats , Cerebral Cortex/surgery , Vestibular Function Tests

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