[Value of correcting microcirculatory disorders of inflammatory foci in the treatment of infection]. / Znachenie likvidatsii mikrotsirkuliatornykh narushenii v zone vospalite'lnogo ochaga pri lechenii sepsisa.

Experience in the treatment of 94 patients with sepsis is discussed. Studies showed that microcirculatory disorders occurring around the inflammatory focus are among the main causes of insufficient efficacy of antibiotic therapy. For correction of the microcirculatory changes, the authors suggest (in addition to vasodilators, inhibitors of proteases and heparin used earlier for this purpose) transfusion of chilled plasma which is a antithrombin-III donator. As the result of such treatment mortality reduced from 45.8 to 16.7%.

[Activation of the blood kallikrein-kinin system as a cause of hemodynamic disorders during traumatic surgery of the liver and bile ducts]. / Aktivatsiia kallikrein-kininovoi sistemy krovi kak prichina vozniknoveniia narushenii gemodinamiki pri travmatichnykh operatsiiakh na pecheni i zhelchnykh putiakh.

Experimental and clinical studies have shown that surgical procedures on the liver and biliary tracts particularly accompanied by compression of the hepatoduodenal ligament in order to perform temporal hemostasis are followed by activation of kinin-formation. In most traumatic operations it exceeds the limits of regulatory mechanisms and is a cause of hemodynamic disturbances. Protease inhibitors are recommended to prevent such complications.