ABSTRACT
The characteristic pulmonary hypertensive effect of the heparin and protamine interaction has been studied in the isolated pig lung preparation using sequential autologous blood perfusate and dextran perfusate. A significant (p less than 0.001) increase in pulmonary artery pressure at constant flow was seen in 10 of 14 dextran and 12 of 15 blood perfusions. The average increase for dextran was 112 percent and for blood, 109 percent. Antihistamines did not inhibit the response. However, this was abolished in all 11 animals treated with aspirin. In 11 intact swine, thromboxane B2 blood levels increased significantly (p less than 0.01) from 0.46 +/- 0.38 ng/dl to 2.97 +/- 1.5 ng/dl. Thus, pulmonary hypertension associated with protamine reversal of heparinization is associated with prostaglandin release from the lung, and this does not require mediation of platelets or leukocytes.
Subject(s)
Heparin/toxicity , Hypertension, Pulmonary/chemically induced , Lung/metabolism , Protamines/toxicity , Thromboxane B2/metabolism , Animals , Blood Pressure/drug effects , Drug Interactions , Heparin/administration & dosage , Hypertension, Pulmonary/metabolism , Hypertension, Pulmonary/physiopathology , Protamines/administration & dosage , SwineSubject(s)
Aneurysm/complications , Iliac Artery , Nerve Compression Syndromes/etiology , Spinal Nerve Roots , Aged , Electromyography , Humans , Male , Rupture, SpontaneousABSTRACT
From this study we conclude that melanoma has a more favorable outcome today than 20 years ago, 2 cm margins around the tumor achieve acceptable survival and local recurrence rates, primary closure is preferred when possible, elective regional node dissection is of questionable value, and further trials are warranted to determine optimal therapy for intermediate thickness melanoma.
Subject(s)
Melanoma/surgery , Skin Neoplasms/surgery , Adult , Age Factors , Female , Follow-Up Studies , Head and Neck Neoplasms/surgery , Humans , Lymph Node Excision , Male , Melanoma/mortality , Methods , Middle Aged , Neoplasm Recurrence, Local/surgery , Prognosis , Retrospective Studies , Skin Neoplasms/mortalityABSTRACT
The effect of delaying surgery, after a nominal standard dose of 4500 rad was administered to the abdomen of rats, on the healing of colonic anastomoses was evaluated. Healing, as determined by bursting pressure of colonic segments, was significantly depressed (p less than 0.05) at five days after surgery in groups irradiated five or 15 days prior to surgery as compared with groups receiving either no radiotherapy or irradiation ten days prior to surgery. Five-day healing was not significantly depressed in the group irradiated ten days prior to operation as compared with the group receiving no irradiation. No significant (p less than 0.05) differences were noted at ten or 15 days after surgery between groups that were and were not irradiated. At ten days after surgery all groups had higher bursting pressures than the control group at five days after surgery. Thus, there appears to be an optimal time interval between radiation and surgery to ensure maximal colonic healing.
