ABSTRACT
The authors compared cytotoxicity of magnetite (Fe3O4) particles in nanometric ranges (10 nm and 50 nm) and micrometer range (1 microm), analyzing changes in cellular subunits of bronchoalveolar lavage in 24 hours after intratracheal application of the particles. Findings are that the nanoparticles are more biologically aggressive than the micrometric particles, but induce more active and effective defensive reaction of alveolar fagocytosis.
Subject(s)
Bronchoalveolar Lavage Fluid/cytology , Ferrosoferric Oxide/toxicity , Metal Nanoparticles/toxicity , Phagocytosis/drug effects , Pulmonary Alveoli/metabolism , Administration, Inhalation , Animals , Bronchoalveolar Lavage Fluid/chemistry , Disease Models, Animal , Ferrosoferric Oxide/administration & dosage , Metal Nanoparticles/administration & dosage , Pulmonary Alveoli/drug effects , Pulmonary Alveoli/pathology , TracheaSubject(s)
Food Additives/pharmacology , Periodicals as Topic , Seafood/standards , Food Industry/standards , Humans , RussiaABSTRACT
The authors summarize theoretical principles of increasing human resistence to toxic effects of inorganic compounds polluting occupational environment and habitat, exemplify practical use of this prophylactic trend.
Subject(s)
Hazardous Substances/toxicity , Inorganic Chemicals/toxicity , Occupational Diseases/chemically induced , Occupational Diseases/prevention & control , Occupational Exposure/adverse effects , Preventive Health Services/organization & administration , Humans , RussiaABSTRACT
The paper presents experimental and theoretical rationales for some methods and means of biological prevention of the toxic effects of a number of heavy metals (lead, chromium, arsenic, cadmium) that pollute the environment. Subchronic experiments were made on laboratory animals exposed to the above substances in combination with various biological agents (sodium glutaminate, the adaptogen saparal, pectin-containing enterosorbent, calcium, the multivitamin-multimineral preparation Pikovit, etc.). They have indicated that the complex use of preparations is more beneficial than they are used alone. The results of controlled trials of biologically preventive preparations on children residing in an area exposed to industrial pollution are presented.