Intragranular starch: comparison of starch USP and modified cornstarch.

Incorporation of starch USP or a modified cornstarch within the granules of several drug formulations was investigated. In general, the formulation containing the modified starch exhibited improved processing characteristics as well as improved tablet properties. A comparison of a granulated and a direct compression formulation of the same ingradients indicated that granulation of an active ingredient is not necessarily detrimental to its (pharmaceutical) availability.