[Willebrand's factor, functional activity of blood platelets and antiaggregation activity of the vascular wall in ischemic heart disease]. / Faktor Villebranda, funktsional'naia aktivnost' trombotsitov i antiagregatsionnaia aktivnost' stenki sosudov pri ishemicheskoi bolezni serdtsa.

Fifty coronary male patients aged 34 to 63 (the mean age 46) and 32 normal male subjects aged 18 to 32 (mean age 23) were examined for the levels of Willebrand's factor, induced platelet aggregation, beta-thromboglobulin, thromboxane, prostacyclin levels, and vascular wall antiaggregation activity (by the cuff test). Basing on literature data and their own findings the authors come to a conclusion that elevated plasma concentration of Willebrand's factor combined with increased functional activity of platelets and reduced vascular wall antiaggregation activity is the key factor in the pathogenesis of atherosclerosis development and progress.

[Vascular-platelet link in the hemostatic system of diabetics]. / Sosudisto-trombotsitarnoe zveno sistemy gemostaza bol'nykh sakharnym diabetom.

Activation of the vascular-platelet link of the hemostasis system: an increase in platelet ADP-induced aggregation, the appearance of platelet aggregates in the vascular bed, an increase in the patients' plasma of beta-thromboglobulin concentration, thrombocytic factor 4, a decrease in antiaggregation activity of the vascular wall and sensitifity of patients' platelets to antiaggregation action of acetylsalicylic acid, was found in diabetes mellitus patients. In the authors' opinion, the above changes play a role in disorders of the microcirculation of the organs and tissues and development of complications in these patients.