Subject(s)
Visual Pathways/physiology , Action Potentials , Animals , Asphyxia/physiopathology , CatsABSTRACT
A method for the fast and reliable evaluation of the sedative and/or antidepressant activity of drugs has been tested. The drugs were administered in very small quantities directly on the cortex of conscious rabbits, and spectrum analysis of the electro-corticogram, recorded from the place of administration, was used to evaluate the potency of the drug. A quantitisation of the obtained results has been elaborated.
Subject(s)
Electroencephalography/methods , Psychotropic Drugs/pharmacology , Animals , Cerebral Cortex/drug effects , Computers , Drug Evaluation, Preclinical/methods , Fourier Analysis , Pain/physiopathology , RabbitsABSTRACT
A method is presented for the harmonic analysis of the human EEG. Its use for the study of schizophrenic patients under phenothiazine treatment is discussed and some examples are given. Correlations are observed with clinical evolution and plasma level of the drugs.
Subject(s)
Electroencephalography , Schizophrenia/physiopathology , Antipsychotic Agents/therapeutic use , Humans , Phenothiazines , Schizophrenia/drug therapy , Time FactorsABSTRACT
The action of neuromuscular blocking agents on the spontaneous sympathetic activity has been quantitated. "On line" spectrum analysis has been applied to the action potential of pre- and post ganglionic nerves of the coeliac plexus. The activity, the frequency spectrum and their changes after the injection of clinical and high doses of decamethonium, D-tubocurarine, succinylcholine, gallamine and pancuronium are determined.
Subject(s)
Neuromuscular Blocking Agents/pharmacology , Sympathetic Nervous System/drug effects , Action Potentials/drug effects , Animals , Cats , Dose-Response Relationship, Drug , Ganglia, Autonomic/drug effectsABSTRACT
The competitive neuromuscular blocking agents, gallamine and pancuronium, enhanced the nictitating membrane contraction, in the cat, resulting from muscarine ganglionic transmission. Inhibition of ganglionic muscarinic hyperpolarization, in response to short tetanic bouts of preganglionic cervical sympathetic stimulation, was an associated event and is considered by us to be causally related. The neuroleptic drug, haloperidol, enhanced ganglionic hyperpolarization under similar stimulatory conditions, and reduced the nictitating membrane contraction elicited via ganglionic muscarine pathways, effects opposite to those produced by the skeletal muscle relaxants. Apomorphine reduced both ganglionic hyperpolarization and the ganglionic muscarinic-induced nictitating membrane contractions. The action of gallamine and pancuronium conforms to a speculative cholinergic antagonism at the specific muscarinic receptors, termed Mi, on the ganglionic dopaminergic interneuron. Haloperiodol and apomorphine are anticipated to be exerting distinct antagonistic and agonistic actions, respectively, on prejunctional dopamine receptors of the ganglionic interneuron. Ganglionic slow depolarization mediated through the muscarinic receptors, termed Me, was unaltered by any of the agents studied.
Subject(s)
Dopamine Antagonists , Ganglia, Autonomic/drug effects , Muscarine/pharmacology , Animals , Apomorphine/pharmacology , Cats , Female , Gallamine Triethiodide/pharmacology , Male , Methacholine Compounds/pharmacology , Nictitating Membrane/drug effectsSubject(s)
Action Potentials , Neurophysiology/instrumentation , Amplifiers, Electronic , ElectrodesABSTRACT
The application of "real time" spectrum analysis to left ventricular pressure during transient phenomena is described. Transient phenomena generated by the injection of drugs (norepinephrine-isoproterenol), anoxia and occlusion of aorta and carotids show sudden changes in the frequency of heart contraction. Propranolol stabilizes the heart rate in similar circumstances.
