ABSTRACT
Twenty-nine infertile couples were treated by intrauterine insemination (IUI) of washed sperm from a sub-fertile husband (n = 16), in cases of gynaecological (n = 3), combined (n = 4) or idiopathic (n = 6) infertility; 116 treatment cycles resulted in 11 ongoing pregnancies. Between 0.25 and 0.45 ml of capacitation medium, containing at least 500,000 pretreated spermatozoa, were inseminated. Pre-treatment of first split fractions was performed by centrifugation and swimming up of motile spermatozoa. The pregnancy per cycle index (P/C) for IUI was 9.5% for a total of 37.9% of all couples treated achieving pregnancy. These results suggest a substantial benefit compared with a calculated six months' cumulative pregnancy rate of 4.2% independent of treatment, for this infertile population. The value of IUI in selected cases of infertility seems obvious but needs further investigation.
Subject(s)
Infertility/therapy , Insemination, Artificial, Homologous , Insemination, Artificial , Specimen Handling/methods , Spermatozoa , Adult , Female , Humans , Male , Ovulation Induction , Pregnancy , Sperm MotilityABSTRACT
Preovulatory ova were harvested from ovarian follicles of eight doe rabbits and transferred into chronic sterile hydrosalpinges induced by infundibular ligation in four rabbits and into chronic infective hydrosalpinges in another four rabbits. Afterwards, normal pregnancies implanted in the uterine horns on the side of the transfer procedures in all four sterile hydrosalpinx rabbits, but in none of the uterine horns of the chronic infective hydrosalpinx group. This points to sequelae of infection rather than simple dilation of the oviductal ampulla as the more potent cause of infertility in the rabbit.
Subject(s)
Fallopian Tube Diseases/complications , Infertility, Female/etiology , Ovum/transplantation , Animals , Chlamydia Infections/complications , Chlamydia trachomatis , Dilatation, Pathologic , Fallopian Tube Diseases/pathology , Fallopian Tubes/pathology , Female , Infertility, Female/pathology , Ovum Transport , Pregnancy , RabbitsABSTRACT
Histologic reaction to nylon, polypropylene, polyglactin-910, and polydioxanone microsutures was assessed in the uterine horn of the rabbit. At 24 days after insertion of the microsuture, a marked infiltration of histiocytes was seen around the nylon, polypropylene, and polydioxanone microsutures, whereas the reaction to polyglactin-910 was characterized by the presence of giant cells. At 80 days after insertion of the microsutures, the polydioxanone was almost entirely absorbed and the reaction to polyglactin-910 was minimal. Moderate histiocytic infiltration persisted around the nylon and polypropylene sutures. Fibrosis was also detected around the nylon and polypropylene sutures at 80 days, but not at all around the polydioxanone and polyglactin-910 sutures. We conclude that polydioxanone leaves little or no tissue reaction at 80 days in the uterine horn of the rabbit.
