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1.
C R Seances Soc Biol Fil ; 179(2): 276-82, 1985.
Article in French | MEDLINE | ID: mdl-2990638

ABSTRACT

Human skin fibroblasts which are naturally resistant to Parvovirus H-1 can be lysed by this virus after SV40 transformation. This observation raises the possibility that oncosuppression by Parvovirus involves a direct oncolytic effect.


Subject(s)
Cell Transformation, Viral , Parvoviridae/pathogenicity , Simian virus 40/physiology , Viral Interference , Animals , Cell Division , Cells, Cultured , Fibroblasts/microbiology , Humans , Skin/microbiology
2.
C R Seances Soc Biol Fil ; 179(2): 283-9, 1985.
Article in French | MEDLINE | ID: mdl-2990639

ABSTRACT

Parvovirus H-1 was used to probe the cellular radiosensitivity of two human degeneration syndromes AT and HC. No difference in the survival of gamma irradiated H-1 was detected between skin fibroblasts from such patients and from a normal individual. However, AT and normal cells were distinguished by the fact that the reactivation of irradiated H-1 could be increased by UV or X-irradiation of the latter but not of the former cells.


Subject(s)
Ataxia Telangiectasia/pathology , Huntington Disease/pathology , Parvoviridae/radiation effects , Virus Activation , Animals , Cell Line , Cell Transformation, Viral , Fibroblasts/microbiology , Fibroblasts/radiation effects , Gamma Rays , Humans , Simian virus 40 , Skin/microbiology , Skin/radiation effects
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