1.
J Surg Oncol
; 106(1): 10-6, 2012 Jul 01.
Article
in English
| MEDLINE
| ID: mdl-22275225
ABSTRACT
Inactivation of Mismatch Repair genes in Lynch Syndrome, caused by inherited mutations, decreases the ability to repair DNA errors throughout life. This deficit may allow the development of any tumor type. Nevertheless, the Syndrome develops a specific tumor spectrum associated with the disease. We think that such spectrum of tumors would be related to the action of certain endogenous carcinogens such as bile acids and estrogens that aggravate the inherited defect.
Subject(s)
Bile Acids and Salts/adverse effects , Carcinogens , Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis , Colorectal Neoplasms, Hereditary Nonpolyposis/genetics , DNA Mismatch Repair/genetics , Estrogens/adverse effects , Microsatellite Instability , Mutation , Colorectal Neoplasms, Hereditary Nonpolyposis/metabolism , Genotype , Humans , Phenotype
2.
Cir Esp
; 81(4): 229-30, 2007 Apr.
Article
in Spanish
| MEDLINE
| ID: mdl-17403364
3.
Cir. Esp. (Ed. impr.)
; 81(4): 229-230, abr. 2007. ilus
Article
in Es
| IBECS
| ID: ibc-053136
ABSTRACT
No disponible
