Subject(s)
COVID-19 , Otorhinolaryngologic Diseases/diagnosis , Phobic Disorders , Early Diagnosis , Humans , Male , Middle AgedABSTRACT
BACKGROUND: Proteus Syndrome (PS) is a rare hamartoneoplastic disorder consisting of a disproportionate and asymmetric overgrowth of body parts, leading to severe body and face disfigurement. Individuals with PS frequently need to undergo a number of surgical procedures including Otolaryngology interventions. Their peculiar anatomy turns even the most straightforward intervention to a challenging one. CASE DESCRIPTION: A 31-year-old adult male with PS presented with recurrent epistaxis and nasal obstruction. A nasal mass was found during the physical examination, which was surgically removed under general anesthesia. Histology revealed juvenile angiofibroma. CONCLUSION: This is the first reported case of a patient with PS presenting with juvenile nasopharyngeal angiofibroma. Although vascular malformations may appear in these patients, juvenile nasopharyngeal angiofibroma should be taken under consideration when PS patients present with recurrent epistaxis. HIPPOKRATIA 2017, 21(3): 147-149.
Subject(s)
Membrane Proteins/genetics , Mutation , Uniparental Disomy/genetics , Urinary Bladder, Neurogenic/etiology , Wolfram Syndrome/genetics , Antidiuretic Agents/therapeutic use , Child , Chromosomes, Human, Pair 4 , Deamino Arginine Vasopressin/therapeutic use , Diabetes Insipidus/diagnosis , Diabetes Insipidus/etiology , Family Health , Female , Hearing Loss, Sensorineural/diagnosis , Hearing Loss, Sensorineural/etiology , Homozygote , Humans , Hydronephrosis/etiology , Hydronephrosis/prevention & control , Mothers , Treatment Outcome , Uniparental Disomy/physiopathology , Urinary Bladder, Neurogenic/drug therapy , Urinary Bladder, Neurogenic/physiopathology , Wolfram Syndrome/physiopathologyABSTRACT
OBJECTIVE: To report and discuss the surgical use of ultrasonography for draining a parapharyngeal space infection in a child. CASE REPORT: The use of image-guided surgery for draining a parapharyngeal abscess has been previously reported, with computed tomography for an intra-oral approach and ultrasound for an external approach. We present the first case report of a four-year-old child with a retropharyngeal abscess and a deep parapharyngeal abscess in whom neck ultrasound was used to assist intra-oral drainage. CONCLUSION: Neck ultrasound may be used in paediatric patients to visualise access to the parapharyngeal space through the intra-oral route for abscess drainage.
Subject(s)
Drainage/methods , Pharyngeal Diseases/diagnostic imaging , Pharyngeal Diseases/surgery , Retropharyngeal Abscess/diagnostic imaging , Retropharyngeal Abscess/surgery , Surgery, Computer-Assisted/methods , Child, Preschool , Female , Humans , Magnetic Resonance Imaging/methods , Tomography, X-Ray Computed/methods , Treatment Outcome , UltrasonographyABSTRACT
Teratomas and dermoids or hairy polyps of the head and neck are rare congenital tumours, often confused and reported to appear as single masses, that may cause upper aerodigestive tract impairment. Their histological classification, origin and embryological basis of development have been a topic of debate in the past and recent literature. We report a case of an infant presenting with a multifocal bigerminal teratoma in the nasopharynx and the neck, causing a deep neck infection, and discuss the unique clinicopathological aspects of this case.
Subject(s)
Head and Neck Neoplasms/diagnosis , Teratoma/diagnosis , Female , Humans , Infant , Magnetic Resonance Imaging , Nasopharyngeal Neoplasms/diagnosis , NeckABSTRACT
The enzyme activity of cancerous tissue and the adjacent normal epithelium of 40 patients with breast cancer was determined. This enzymatic activity was correlated with the responsiveness of those tumors to the chemotherapy. It was found that the presence of cytochrome oxidase and alkaline phosphatase and the absence of leucine aminopeptidase, beta-glucuronidase and dehydrogenases in cancerous tissues was related to good response. On the contrary, the absence of alkaline phosphatase and cytochrome oxidase and the presence of leucine aminopeptidase, beta-glucuronidase and dehydrogenases in the cancerous tissues was related to poor response and therefore to poor survival.
Subject(s)
Breast Neoplasms/drug therapy , Alkaline Phosphatase/metabolism , Aminopeptidases/metabolism , Breast Neoplasms/enzymology , Electron Transport Complex IV/metabolism , Female , Glucuronidase/metabolism , Histocytochemistry , Humans , Menopause , Middle Aged , Oxidoreductases/metabolism , PrognosisABSTRACT
Serum glutathione reductase activity decreases on standing at room temperature. Dilution of the sample slows this decay in sera from patients with a variety of clinical disorders, and reverses the inactivation in sera from patients with liver or biliary tract disease. Prolonged contact with dithioeythritol or acetate buffer, pH 6.4, at 4 degrees C prevents spontaneous inactivation of the native serum and abolishes the effect of dilution. These hitherto unreported phenomena are a source of potential inaccuracy in assays for this enzyme. The inactivation may be the result of conformational folding with "burying" of active sites, or of molecular aggregation brought about by hydrogen bonding or disulfide bond formation.
Subject(s)
Glutathione Reductase/blood , Alanine Transaminase/blood , Anemia, Pernicious/enzymology , Animals , Aspartate Aminotransferases/blood , Autoanalysis , Biliary Tract Diseases/enzymology , Cattle , Dithiothreitol/pharmacology , Erythrocytes/enzymology , Humans , Isocitrate Dehydrogenase/blood , Kinetics , Liver Diseases/enzymology , Methods , Myocardial Infarction/enzymology , Neoplasms/enzymology , Quality ControlABSTRACT
An improved and optimized method for serum glutathione reductase is described. The reference range for normal subjects is 47-79 IU/1. The method is more sensitive than conventional enzyme tests in the detection of malignant disease. It was not raised more frequently in patients with clinical evidence of metastases than in those clinically free of such metastases, and it did not seem to correlate with prognosis among those patients who failed to survive six months from the time the analysis was first conducted.
