[The use of obzidan and metoprolol in patients with supraventricular systolic tachyarrhythmias]. / Primenenie obzidana i metoprolola u bol'nykh s supraventrikuliarnymi takhisistolicheskimi aritmiiami.

Having analyzed the electrophysiological mechanisms and state of humoral regulatory substances in 87 patients with paroxysmal disorders of the cardiac rhythm the authors determined the antiarrhythmic action of two beta-blockaders: obsidan and metoprolol. They found a reduction of the sinus node function under the effect of obsidan and to a lesser degree under the effect of metoprolol. Metoprolol produced a high antiarrhythmic effect, particularly in supraventricular tachycardias with participation of abnormal conduction pathways.