Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 29
Filter
Add more filters










Publication year range
1.
Pathog Glob Health ; 116(5): 297-304, 2022 07.
Article in English | MEDLINE | ID: mdl-35138229

ABSTRACT

The early administration of anti-SARS-CoV-2 monoclonal antibodies (mAb) could decrease the risk of severe disease and the need of inpatients care. Herein, our clinical experience with Bamlanivimab/Etesevimab for the treatment of early SARS-CoV-2 infection through an outpatient service was described. Patients with confirmed COVID-19 were selected by General Practitioners (GPs) if eligible to mAb administration, according to manufacturer and AIFA (Agenzia-Italiana-del-Farmaco) criteria. If suitability was confirmed by the Multidisciplinary Team, the patient was evaluated within the next 48-72 hours. Then, all patients underwent a medical evaluation, followed by mAb infusion or hospitalization if the medical condition had worsened. Overall, from March 29th to June 4th, 2021, 106 patients with confirmed COVID-19 were identified by GPs; 26 were considered not eligible and then excluded, while 9 refused treatment. Among the 71 remaining, 6 were not treated because of worsening of symptoms soon after selection. Finally, 65 received mAb therapy. All treated patients survived. However, 2/65 developed adverse events (allergic reaction and atrial fibrillation, respectively) and 6/65 needed hospitalization. By performing univariate logistic regression analysis, diabetes was the only risk factor for hospitalization after mAb administration [aOR = 9.34, 95%CI = 1.31-66.49, p= .026]. Importantly, subjects who worsened awaiting mAb were more frequently obese (OR = 16.66, 95%CI = 1.80-153.9, p= .013) and received home corticosteroid therapy for COVID-19 (OR = 14.11, 95%CI = 1.53-129.6, p= .019). Establishing a network among GPs and COVID units could be an effective strategy to provide mAb treatment to patients with early SARS-CoV-2 infection to reduce hospitalizations and pressure on healthcare systems.


Subject(s)
COVID-19 Drug Treatment , Antibodies, Monoclonal, Humanized , Antibodies, Neutralizing , Antibodies, Viral , Humans , Outpatients , SARS-CoV-2
2.
J Prim Care Community Health ; 11: 2150132720985055, 2020.
Article in English | MEDLINE | ID: mdl-33372570

ABSTRACT

Telemedicine services can be classified into the macro-categories of specialist Telemedicine, Tele-health and Tele-assistance. From a regulatory perspective, in Italy, the first provision dedicated to the implementation of Telemedicine services is represented by the Agreement between the Government and the Regions on the document bearing "Telemedicine-National guidelines," approved by the General Assembly of the Superior Health Council in the session of 10th July 2012 and by the State Regions Conference in the session of 20th February 2014. Scientifically, several studies in the literature state that information and communication technologies have great potential to reduce the costs of health care services in terms of planning and making appropriate decisions that provide timely tools to patients. Another clear benefit is the equity of access to health care. The evolution of telemedicine poses a series of legal problems ranging from the profiles on the subject of authorization and accreditation to those concerning the protection of patient confidentiality, the definition and solution of which, in the absence of specific regulatory provisions, is mainly left to the assessment of compatibility of the practices adopted so far, with the general regulatory framework. In terms of professional liability, it is necessary to first clarify that the telemedicine service is comparable to any diagnostic-therapeutic health service considering that the telemedicine service does not replace the traditional health service, but integrates the latter to improve its effectiveness, efficiency and appropriateness.


Subject(s)
COVID-19/epidemiology , Liability, Legal , Telemedicine/organization & administration , Chronic Disease , Communication , Confidentiality , Humans , Inpatients , Italy/epidemiology , Models, Organizational , Outpatients , SARS-CoV-2 , Telemedicine/legislation & jurisprudence , Telemedicine/standards
3.
J Hosp Infect ; 105(3): 454-458, 2020 Jul.
Article in English | MEDLINE | ID: mdl-32445776

ABSTRACT

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-related infection has a major impact on public health, and healthcare workers (HCWs) are exposed to high biological risk. This paper describes the prevention procedures introduced at the University Hospital of Bari, Italy to reduce the risk to HCWs, consisting of enhanced preventive measures and activation of a report system to collect HCWs' contacts. Twenty-three confirmed cases of infection (0.4% of all HCWs) were reported in the 30-day observation period following implementation of the protocol. This shows that correct management of HCWs' contacts is essential to avoid nosocomial clusters.


Subject(s)
Betacoronavirus , Coronavirus Infections/prevention & control , Cross Infection/prevention & control , Hospitals, University , Pandemics/prevention & control , Personnel, Hospital/psychology , Pneumonia, Viral/prevention & control , COVID-19 , Coronavirus Infections/epidemiology , Cross Infection/epidemiology , Humans , Infectious Disease Transmission, Patient-to-Professional/prevention & control , Infectious Disease Transmission, Patient-to-Professional/statistics & numerical data , Italy/epidemiology , Pneumonia, Viral/epidemiology , SARS-CoV-2
4.
Clin Ter ; 171(3): e245-e252, 2020.
Article in English | MEDLINE | ID: mdl-32323714

ABSTRACT

INTRODUCTION: The main source of mortality data is the death certificate. The forms must be filled in correctly because inaccuracy can lead to the misallocation of resources in health care programs and research. OBJECTIVES: The main purpose was to verify the existence of any relationships and/or correlations between the deaths of the Polyclinic of Bari and some specific elements by carrying out a "risk adjusted" analysis that represents a real indicator of the quality of care. MATHERIALS AND METHODS: All death records of patients who died in the Bari Polyclinic (over 1.500 beds) in 2017 (1.005 patients) were analysed. For each card, the corresponding medical records have been evaluated. RESULTS: The main causes of death are cardiovascular and neoplastic diseases, in line with statistics carried out on a national basis. Infectious and parasitic diseases represent the third cause of death with a discrepancy with the national average mainly due to the high incidence of nosocomial infections in European hospitals. There were no statistically significant differences in the frequency of deaths per shift and per ward. Patients suffering from infectious and digestive system diseases are more at risk of dying in the afternoon. An increased risk of death in the last hours of the night shift has been demonstrated. DISCUSSION AND CONCLUSIONS: These findings indicate the need to adopt, in case of adverse events due to changes in the quality of care, the necessary barriers to prevent the occurrence of active or latent errors against patients exposed to this risk.


Subject(s)
Cause of Death , Hospitals, Teaching/statistics & numerical data , Adolescent , Adult , Aged , Aged, 80 and over , Cardiovascular Diseases/mortality , Death Certificates , Female , Humans , Italy , Male , Middle Aged , Neoplasms/mortality , Quality of Health Care , Young Adult
5.
Compr Psychiatry ; 60: 161-7, 2015 Jul.
Article in English | MEDLINE | ID: mdl-25863646

ABSTRACT

BACKGROUND: "Depersonalization" (DP) is a common symptom in the general population and psychiatric patients (Michal et al., 2011 [1]). DP is characterized by an alteration in the experience of the self, so that one feels detached from his or her own mental processes or body (or from the world), feeling as being an outside observer of his or her own self, and loosing the experience of unity and identity (American Psychiatric Association, 2013 [2]). AIM: We performed an exploratory factor analysis of the Cambridge Depersonalization Scale Italian version (CDS-IV). METHODS: We enrolled 149 inpatients and outpatients of psychiatric services located in two Italian regions, Lazio and Campania. Patients were aged between 15 and 65 and diagnosed with schizophrenic, depressive or anxiety disorders. RESULTS: Four factors accounted for 97.4% of the variance. Factor 1 (10, 24, 26, 1, 13, 23, 9, 2, 5, and 11), called "Detachment from the Self", captures experiences of detachment from actions and thoughts. Factor 2 (19, 20, 27, 3, 12, 23, 22, and 11), called "Anomalous bodily experiences", refers to unusual bodily experiences. Factor 3 (7, 28, 25, 6, 9, and 2), named "Numbing", describes the dampening of affects. Factor 4 (14, 17, and 16), named "Temporal blunting", refers to the subjective experience of time. We did not find any specific factor that refers to derealization; this suggests that the constructs of depersonalization/derealization (DP/DR) were strongly related to each other. CONCLUSIONS: Our results show that the constructs of DP/DR subsume several psychopathological dimensions; moreover, the above mentioned factors were broadly consistent with prior literature.


Subject(s)
Anxiety Disorders/psychology , Depersonalization/psychology , Dissociative Disorders/psychology , Surveys and Questionnaires/standards , Adolescent , Adult , Aged , Factor Analysis, Statistical , Female , Humans , Italy , Male , Middle Aged , Translations
6.
Forensic Sci Int Genet ; 7(1): e3-4, 2013 Jan.
Article in English | MEDLINE | ID: mdl-22960096

ABSTRACT

The 17 Y-STR loci included in the AmpFLSTR Yfiler PCR Amplification Kit were analyzed in 98 unrelated healthy males from Apulia (Southern Italy). A total of 97 different haplotypes were identified, of which 96 haplotypes were unique and 1 occurred twice. Allele frequencies for each Y-STR locus in pooled sample and estimated value of gene diversity (GD) were evaluated. The lowest value of GD was observed for DYS392 (0.126) and the highest one (0.936) for DYS385. The HD (haplotype diversity) for the studied Y-STR set showed a value of 0.9994, with an HMP (haplotype match probability) value of 0.0006, while the overall DC was 98.98%. Microvariant alleles were found for the DYS458 and DYS385 markers and sequenced. Furthermore, Φ(st)-based genetic distance computation and pair-wise analysis of molecular variance (AMOVA) test were carried out. When comparing our population with the Apulia sample previously investigated, the AMOVA analysis detected no evidence for significant differentiation. The comparison with all Italian populations submitted to the YHRD website showed no relevant differences with all Southern Italian populations (San Giorgio La Molara, Belvedere, Trapani and Catania) and significant genetic deviation with all Northern Italian populations (Udine, Biella, La Spezia, Modena, Ravenna, Marche and North Sardinia). Moreover, the other populations and meta-populations belonging to the whole Mediterranean area (Croatia, Macedonia, Albania, Greece, Turkey, Israel, Libya, Tunisia, Algeria, Morocco and Spain) were different from our Apulia sample. The data were submitted to YHRD.


Subject(s)
Chromosomes, Human, Y , Genetics, Population , Microsatellite Repeats , Gene Frequency , Haplotypes , Humans , Italy
7.
Forensic Sci Int Genet ; 7(2): e35-6, 2013 Feb.
Article in English | MEDLINE | ID: mdl-23127759

ABSTRACT

Allele frequencies of five miniSTRs loci (D1S1656, D2S441, D12S391, D10S1248 and D22S1045) included in the new European Standard Set (ESS) were calculated from a sample of 150 unrelated individuals from Apulia, a Region of Southern Italy. Two different PCR Amplification Kits were used, in order to evaluate the concordance of the genotypes. The results obtained with the two kits showed no differences in all genotype profiles. No deviation from Hardy-Weinberg expectations was detected at either locus. Moreover genetic analysis using Fst estimation showed no evidence for differentiation at the five new loci between Apulia and Italian populations. The high levels of polymorphisms of the analyzed markers in the Apulian population allow to confirm that these markers are useful tools in paternity and forensic analysis from degraded DNA samples.


Subject(s)
Gene Frequency , Europe , Humans , Italy , Polymerase Chain Reaction
9.
Iran J Public Health ; 39(4): 26-34, 2010.
Article in English | MEDLINE | ID: mdl-23113035

ABSTRACT

BACKGROUND: Exposure to formaldehyde (FA) causes irritative effects and induces nasopharyngeal cancer; the International Agency for Research on Cancer (IARC, Lyon) classified FA as carcinogenic to humans, Group 1. Many studies have been published so far concerning the occupational exposure of industrial workers, embalmers, pathologists and anatomists to FA but very few data regarding medical examiners are available. METHODS: To assess the extent to which subjects were exposed to FA, airborne concentrations of this chemical were measured by High Performance Liquid Chromatography (HPLC). In September-October 2006 we examined the personnel, which worked in an autopsy room (medical examiners) and in three laboratories of pathologic anatomy of the University Medical School of Bari, Policlinico Hospital, Southern Italy. Irritative effects were also investigated. RESULTS: All the personal exposure data obtained exceeded the National Institute for Occupational Safety and Health Threshold Limit Value-Time Weighted Average (NIOSH TLV-TWA: 0.02 mg/m(3)) and, in a few cases, even the American Conference of Industrial Hygienists Threshold Limit Value-Ceiling level (ACGIH TLV-C: 0.37 mg/m(3)). CONCLUSION: Irritative effects in more than 50% of the workers enrolled, increasing the risk of injuries.

10.
Minerva Stomatol ; 56(1-2): 45-51, 2007.
Article in English, Italian | MEDLINE | ID: mdl-17287706

ABSTRACT

In recent years the high number of malpractice lawsuits in dentistry has attracted closer attention of dental practitioners to its medico-legal aspects. Implantology, in particular, presents many points of medico-legal concern connected with the difficulties inherent to dental procedures and objectives (both functional and esthetic), as well as full patient collaboration as an essential part of successful treatment. An accurate assessment of each case by the clinician is fundamental, especially in circumstances where esthetic considerations are preponderant as, for instance, in the frontal sectors. In such cases, the options of implantology or of a traditional fixed prosthesis need to be carefully weighed in light of the patient's anatomic condition. The patient should therefore receive complete information and be made fully aware of the risk of treatment failure, as well as possible complications, limits to the procedures, and the fact that successful outcome will also depend on her/his scrupulous observance of the practitioner's instructions. In short, the aim is to make the patient an active ''accomplice'' in treatment. To this end, the use of an extremely detailed information leaflet is strongly advised; after careful clarification of any doubts the patient may have, the patient's written informed consent should be obtained. Nevertheless, there is the risk that excessive intrusion of bureaucracy into medical procedures in defence of the practitioner against malpractice suits may hinder the principal aim of traditional medicine, i.e. to provide the best care for the patient through mutual trust fostered within the doctor-patient relationship.


Subject(s)
Dental Implantation , Esthetics , Legislation, Dental , Beauty , Dental Implants/psychology , Female , Forensic Dentistry , Humans , Informed Consent/legislation & jurisprudence , Italy , Male , Patient Compliance , Patient Education as Topic , Patient Satisfaction
11.
G Ital Med Lav Ergon ; 29(3 Suppl): 266-8, 2007.
Article in Italian | MEDLINE | ID: mdl-18409678

ABSTRACT

The aim of the present study is to evaluate the personal exposure to formaldehyde in an autopsy room and in three pathological anatomy laboratories. Passive sampling for the whole workshift and HPLC analysis were performed. The final result showed a remarkable exposure of the workers enrolled. All the data obtained exceeded the NIOSH-TWA and several cases personal of exposure levels above the ACGIH-Ceiling value (0,37 mg/m3) were observed in the anatomy laboratory.


Subject(s)
Autopsy , Formaldehyde/adverse effects , Laboratories , Occupational Exposure/adverse effects , Pathology , Humans
12.
Transplant Proc ; 37(6): 2439-44, 2005.
Article in English | MEDLINE | ID: mdl-16182702

ABSTRACT

Kidney transplantation is quite a routine complex procedure, not without risks and consequences to the donor, the recipient, and the health care professionals. Kidney-related medical malpractice suits are growing rapidly, and for clinicians and surgeons, the risk of being sued can be only reduced by practicing high-quality medicine and by appropriately communicating with donors and recipients. Actually relevant guidelines are available including safety and quality assurance standards for procurements, preservation, processing, and distribution for organs to maximize their quality and thereby the rate of success of transplants and to minimize the risk of such a procedure. We also find it essential that practice of living donor kidney transplant is in line with the general rules of the Convention for the Protection of Human Rights and its Additional Protocol. In this article, financial incentives and insurance aspects related with living donors kidney transplants are also illustrated.


Subject(s)
Kidney Transplantation/economics , Living Donors , Nephrectomy/economics , Tissue and Organ Harvesting/economics , Human Rights , Humans , Insurance, Health , Italy , Kidney Transplantation/standards , Malpractice , Quality Assurance, Health Care , Safety , Tissue and Organ Harvesting/standards
13.
Water Sci Technol ; 48(1): 179-84, 2003.
Article in English | MEDLINE | ID: mdl-12926635

ABSTRACT

P-control technologies for municipal wastewater are essentially based on "destructive" methods, that lead to formation of concentrated solid-phases (sludge), usually disposed-off in controlled landfills. Ion exchange, as a "non-destructive" technology, allows for selective removal and simultaneous recovery of pollutants, which can be recycled to the same and/or related productive lines. In this context, the REM NUT process removes nutrient species (HPO4 = , NH4+, K+) present in biologically oxidised municipal effluents and recovers them in the form of struvites (MgNH4PO4; MgKPO4), premium quality slow release fertilisers. The main limitation to the extensive application of this ion exchange based process is the non-availability of selective exchangers for specific removal of nutrient species. This paper illustrates laboratory investigation and pilot scale development of a so-called "P-driven" modified REM NUT scheme based on a new phosphate-selective sorbent developed at Lehigh University, PA, USA.


Subject(s)
Phosphorus/isolation & purification , Waste Disposal, Fluid/methods , Adsorption , Conservation of Natural Resources , Fertilizers , Magnesium Compounds/chemistry , Phosphates/chemistry , Phosphates/isolation & purification , Sewage/chemistry , Struvite
14.
J Mol Spectrosc ; 191(1): 45-8, 1998 Sep.
Article in English | MEDLINE | ID: mdl-9724579

ABSTRACT

The equatorial conformer of pyrrolidine has been discovered while investigating the rotational free jet spectrum of the pyrrolidine-water adduct. It is more stable than the axial species, previously assigned with conventional microwave spectroscopy (W. Caminati, H. Oberhammer, G. Pfafferott, R. R. Filgueira, and C. H. Gomez, 1984. J. Mol. Spectrosc., 106, 217-266). The assignment of the equatorial conformer was missed in that microwave investigation because of the accidentally zero or almost zero value of its µa dipole moment component; its low J µc-type transitions, very weak in the room temperature spectrum, are the strongest lines in the jet. Copyright 1998 Academic Press.

15.
Am J Forensic Med Pathol ; 19(1): 87-92, 1998 Mar.
Article in English | MEDLINE | ID: mdl-9539400

ABSTRACT

Certain methods of homicide used by the Italian Mafia are intended to have an admonitory significance. One such method is the so-called "incaprettamento." This study analyzes 18 cases of homicidal ligature strangulation in which the body was found in this typical position. The circumstances of the crime and the macroscopic and microscopic evidence were evaluated to determine whether or not the ligatures on the wrists and ankles were placed antemortem or postmortem.


Subject(s)
Ankle Injuries/pathology , Asphyxia/pathology , Homicide , Neck Injuries/pathology , Torture , Wrist Injuries/pathology , Adult , Ankle Injuries/etiology , Asphyxia/etiology , Contusions/pathology , Crime , Humans , Italy , Male , Middle Aged , Neck Injuries/etiology , Wrist Injuries/etiology
16.
J Forensic Sci ; 43(1): 215-7, 1998 Jan.
Article in English | MEDLINE | ID: mdl-9456549

ABSTRACT

In traffic accident victims, the seat belt syndrome is a well known injury which rarely involves the common iliac artery due to its posterior anatomical position and to protection by the pelvis. We report a case of blunt abdominal trauma related to the type of seat belt worn. The trauma provoked subintimal haemorrhaging of the left common iliac artery, without skeletal lesions or other visceral injuries. Correct diagnosis was delayed for three months after the crash, when an angiogram was performed to investigate disabling claudication and vascular pulse change in the left leg. This arterial injury could have been related to the association of two different types of force created during the crash ("compression/deceleration-type mechanism") that might have produced shearing forces causing a vascular wall discontinuity and/or an intimal flap. The authors speculate that the vascular lesion was observed on the same (left) side as the fastening point of the seat belt (a lap-and-shoulder belt with a three-point attachment) where the shearing forces may have been most intense due to the junction between the lap strap and the diagonal shoulder belt.


Subject(s)
Abdominal Injuries/etiology , Accidents, Traffic , Iliac Artery/injuries , Seat Belts/adverse effects , Wounds, Nonpenetrating/etiology , Abdominal Injuries/complications , Abdominal Injuries/prevention & control , Adult , Angiography , Autopsy , Back Pain/etiology , Constriction, Pathologic , Forensic Medicine , Humans , Iliac Artery/diagnostic imaging , Iliac Artery/pathology , Intermittent Claudication/etiology , Italy/epidemiology , Male , Wounds, Nonpenetrating/complications , Wounds, Nonpenetrating/prevention & control
17.
Intensive Care Med ; 23(1): 119-21, 1997 Jan.
Article in English | MEDLINE | ID: mdl-9037652

ABSTRACT

We describe a patient in whom clinical evidence of liver and lung dysfunction developed after he received the second dose of recombinant hepatitis B vaccine, despite no serologic evidence of viral hepatitis. However, liver biopsy specimens demonstrated both surface antigens and core antigens, possibly indicating silent hepatitis B virus infection. A search for an infective etiology for the patient's subsequent clinical deterioration in lung function did not yield pathogens: postmortem examination revealed evidence of immune complex-mediated organ injury in the liver, lungs, and kidneys.


Subject(s)
Chemical and Drug Induced Liver Injury/etiology , Hepatitis B Vaccines/adverse effects , Liver/pathology , Respiratory Distress Syndrome/etiology , Antigen-Antibody Complex , Fatal Outcome , Humans , Liver/virology , Male , Middle Aged
18.
SELECTION OF CITATIONS
SEARCH DETAIL
...