Perinatal, neonatal, and rearing period mortality of dairy calves and replacement heifers in France.

Dairy calf and replacement heifer mortality in France was assessed by calculating mortality rates at 0 to 2d (calves), 3d to 1 mo (calves and heifers), 1 to 6 mo of age, and 6 mo of age to first calving (heifers) using the national identification database. Between birth and 2-d-old, 261,000 and 251,000 of the 3.56 and 3.43 million calves born in 2005 and 2006, respectively, died. The overall 0- to 2-d-old calf mortality rate was around 6.7%, which is similar to the low range of values reported in the literature. Among the 2.38 and 2.39 million calf-month, 139,000 and 133,000 died between 3d and 1 mo of age in 2005 and 2006, respectively. Among the 3d to 1 m of age group, dairy calf mortality rate was around 5.7%. Such a rate has not been reported previously because of the great differences in age classes between studies. For the 0- to 2-d-old and 3-d- to 1-mo-old calves, annual mortality was zero on 26 and 44% of the farms, respectively. Calf mortality during the first month of life increased in winter (to 12-17%) and decreased in summer (to 8-12%), with a small peak in June or July. Mortality during the first month of life is higher in males than in females, with a mortality odds ratio of 1.20 (and 95% confidence interval of 1.19-1.21). Such a difference is also found within the noncrossed or beef-crossed calf subpopulations. Disregarding the sex, the mortality of beef-crossed calves is slightly less than that of noncrossed dairy calves, with a mortality odds ratio of 0.98 (and 95% confidence interval of 0.98-0.99) before 1 mo of age. In heifers, around 51,000, 35,000, and 40,900 out of the 1.2 million 3-d- to 1-mo-old, 1.1 million 1- to 6-mo-old, and 950,000 6-mo-old to first calving heifers died, respectively. The respective mortality rates were 4.5, 3.1, and 4.1%; these rates are similar to the low range of values previously published. The proportions of farms with no heifer mortality during a year were higher than for calves, between 60 and 70%. The mortality probability for heifers was very high for the first day of life (95% survival between 2-30 d of age), then decreased during the first year of life and became constant up to around 3 yr of age (88% survival at 36 mo of age). The risk of mortality is higher in Montbéliarde and Normande heifers compared with Holstein. In conclusion, and beyond the average mortality rates, farmers and farm advisors should keep in mind the broad range of mortality values, which shows that very low mortality (1-2%) can be achieved, even in animals with a known high risk of mortality, such as beef-crossed dairy calves.

Revisiting the concept of 'vulnerability'.

The terms 'vulnerable' and 'vulnerability' are used more and more frequently in the areas of both social science research into and prevention of HIV/AIDS, but certain difficulties arise when it comes to applying this concept to actual situations at the heart of which individuals or groups are more exposed to HIV. The concept of vulnerability must thus be clarified to reinforce its heuristic capacity and political and practical relevancy. The first part of this paper is devoted to presenting a heuristic matrix of vulnerability, used in previous research among people living with HIV/AIDS (PWHAs) and to extracting three levels of intelligibility, that is to say, first the social trajectory level, then the level on which two or more trajectories intersect, and finally that of the social context. Each of the elements belonging to these three levels must be described both objectively and subjectively. The identity construction processes are then proposed as particular observation and 'gelling' points for these various levels taken as a whole. In the second part of the paper, we have reviewed how the concept of 'vulnerability' has been defined and used in other fields, notably disaster, famine, and mental health, paying special attention to the crucial points in the debates that are raging in these fields. We have also shed light on a few concepts that are frequently associated with vulnerability, such as victimization, insecurity, and risk. In the third part, we have summarized our approach to vulnerability as a relevant concept for elucidating risk-taking processes and designing intervention programmes. The importance of analysing the inter-individual differences, the variability in time and the relational dimension of all social vulnerability has been stressed.

Synthesis and antimicrobial properties of new aroyl-acrylic esters of polyethylene glycols.

Eight new aroyl-acrylic esters of polyethylene glycols were prepared using different synthetic ways. They are supposed to possess a higher activity as antimicotic agents for topical use, by favouring skin absorption. Except in few cases, the antimicrobial activity of the oligomeric derivatives resulted generally decreased in vitro, in comparison to simple alkyl esters previously prepared. However, only pharmacological screenings for antimicotic activity in vivo will give a definite response on whether the new derivatives are advantageous for topical use.