ABSTRACT
OBJECTIVE: To determine if significant gender differences existed between subjects 65 years of age and older, with regard to calcium, phosphorus, and alkaline phosphatase levels. DESIGN: A retrospective chart review of laboratory procedures performed in six different physician practices. The data consisted of 178 subjects representing 92 males and 86 females over the age of 65. DATA SOURCES: Patient data were obtained from the charts housed in a cardiac care center. Subjects, with charts preceding them, were referred by a physician to the cardiac center. The laboratory procedures had been performed previously in the laboratories of the referring physicians. MAIN OUTCOME MEASURES: After accounting for variation between laboratories, mean values of calcium, phosphorus, and alkaline phosphatase were examined to establish if a gender difference existed in patients over the age of 65. A blocked analysis of variance (ANOVA) was conducted at the 0.05 significance level. RESULTS: ANOVA analysis yielded significant gender differences for calcium, phosphorus, and alkaline phosphatase (p < 0.05). Females over the age of 65 consistently showed higher levels than males over the age of 65 for all three variables in five of the six laboratories studied. CONCLUSION: A statistically significant difference was found between the mean levels of men and women 65 years of age and older for calcium, inorganic phosphorus, and alkaline phosphatase. Gender and age are important variables to consider when analyzing and interpreting calcium, phosphorus, and acid phosphatase levels.
