ABSTRACT
The authors discuss the results of application of melatonin in patients with hypertensive disease. Treatment with melatonin facilitated normalization of arterial pressure and cerebral hemodynamics at night time.
Subject(s)
Blood Pressure/drug effects , Cerebrovascular Circulation/drug effects , Hypertension , Melatonin , Blood Pressure Monitoring, Ambulatory/methods , Central Nervous System Depressants/administration & dosage , Central Nervous System Depressants/adverse effects , Circadian Rhythm/drug effects , Humans , Hypertension/diagnosis , Hypertension/drug therapy , Hypertension/metabolism , Hypertension/physiopathology , Male , Melatonin/administration & dosage , Melatonin/adverse effects , Middle Aged , Treatment OutcomeABSTRACT
Laser radiation (XeCl laser, 308-nanometer wavelength) focused into a cell containing Mo(CO)(6) vapor produced ultrafine particles in the extended waist of the laser beam. Negative ion mass spectrometry revealed molybdenum carbide cluster ions with a stoichiometry MonC4n (n = 1 to 4). The MonC4n(-) (n = 2 to 4) ions are completely unreactive with NH(3), H(2)O, and O(2), suggesting structures in which the molybdenum atoms are unavailable for coordination to additional ligands. Collision-induced dissociation studies of these anions show the loss of MoC(4) units as the main fragmentation pathway. This observation, together with the lack of addition reactions, provides a basis for structures in which a planar cluster of two, three, or four molybdenum atoms is surrounded by, and bonded to, carbon dimers.
