ABSTRACT
The present article is the result of examination of 2678 women. Of these, 316 subjects had the papillomavirus-associated abnormalities of the neck of the uterus. The described method is a highly efficient and essential tool in a complex diagnosis of papillomavirus infection.
Subject(s)
Cervix Uteri/pathology , Papillomaviridae , Papillomavirus Infections/pathology , Tumor Virus Infections/pathology , Uterine Diseases/pathology , Biopsy , Colposcopy , Condylomata Acuminata/pathology , Female , Humans , Precancerous Conditions/pathology , Uterine Cervical Neoplasms/pathology , Uterine Cervicitis/pathologyABSTRACT
Four laboratories, two in the Czech Republic (Brno and Prague) and two in the CIS (Moscow and Duschanbe), participated in the International Programme on Chemical Safety's (IPCS) collaborative study to evaluate the utility of the most commonly used plant test systems, including the Arabidopsis thaliana assay, for assessing the mutagenic potential of environmental agents. Out of the five compounds evaluated in the Arabidopsis assay, three compounds, i.e., ethyl methanesulfonate, N-methyl-N-nitrosourea, and azidoglycerol, were reported to be mutagenic by all four participating laboratories. Sodium azide (NaN3) demonstrated a negative response in all four laboratories, whereas maleic hydrazide was reported to be weakly mutagenic by one laboratory and nonmutagenic by the other three laboratories.