1.
Bioorg Med Chem Lett
; 14(3): 727-9, 2004 Feb 09.
Article
in English
| MEDLINE
| ID: mdl-14741277
ABSTRACT
A series of 3-(2-pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives (2) has been prepared using parallel synthesis techniques, and their structure-activity relationships studied. High affinity human 5-HT(1B/1D) (h5-HT(1B/1D)) ligands have been identified.
Subject(s)
Indoles/chemistry , Indoles/metabolism , Pyridines/chemistry , Pyridines/metabolism , Receptor, Serotonin, 5-HT1B/metabolism , Humans , Ligands , Structure-Activity Relationship
2.
Bioorg Med Chem Lett
; 13(20): 3419-21, 2003 Oct 20.
Article
in English
| MEDLINE
| ID: mdl-14505640
ABSTRACT
A series of (R)-3-(N-methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives (2) have been prepared using parallel synthesis, and their structure-activity relationship studied. High affinity human 5-HT(1B/1D) (h5-HT(1B/1D)) ligands have been identified.
Subject(s)
Pyridines/chemistry , Receptor, Serotonin, 5-HT1B/metabolism , Receptor, Serotonin, 5-HT1D/metabolism , Humans , Ligands , Pyridines/chemical synthesis , Pyridines/metabolism , Structure-Activity Relationship
3.
Bioorg Med Chem Lett
; 12(17): 2451-4, 2002 Sep 02.
Article
in English
| MEDLINE
| ID: mdl-12161155
ABSTRACT
A novel series of 1-(bicyclopiperazinyl)ethylindole and 1-(homopiperazinyl)ethyl-indole derivatives was synthesized and found to be potent and selective 5-HT(7) receptor ligands.
