ABSTRACT
Disturbances in coordination between physiological functions of the cardiovascular system develop in healthy people as a result ofdisordered sleep-wake cycle especially associated with psycho-emotional stress. A classical example is desynchronosis in locomotive drivers. Similar condition develops in association with severe somatic pathology e.g. in oncological patients. The study was designed to analyse peculiarities of desynchronosis associated with shift-based jobs and in the patients with oncological diseases. The control group was comprised of the students and teachers of the University of People's Friendship. Diagnostics and evaluation of desynchronosis severity were performed by complex correlation-regressive analysis and pre-trip AP and HR measurements in locomotive drivers. In healthy subjects, all regression coefficients were positive and significant in combination with middle-strength correlation coefficients which ensured maximum coordination in the work of the coupled systems without the loss of plasticity between physiological contours. Patients with severe somatic pathology showed multidirectional functioning of physiological contours (stable dyscoordination) with the enhanced relationship between the parameters of interest and with manifestations of "rigidity". Multidirectional functioning of coupled systems was equally characteristic of locomotive drivers, but the relationship between the parameters being studied was less expressed and attributable to an adaptive reaction because the relationship recovered during the rest periods between shifts.
