ABSTRACT
A hypothesis is suggested on the positive effect of light radiation on the formation of protective immune mechanism related to the photophysiological destruction of porphyrins. References to experimental data are given which illustrate the possibility for existence of such a mechanism.
Subject(s)
Immunity, Innate/radiation effects , Immunization , Sunlight , Bilirubin/radiation effects , Humans , Immunity, Innate/physiology , Oxygen/radiation effects , Photochemistry , Porphyrins/immunology , Porphyrins/radiation effects , Singlet OxygenABSTRACT
A radioimmune method of AIDS diagnostics is proposed. Diphenylhydantoin sodium (diphenine sodium) is used as haptene in a probe. It binds to the T-cell membrane and has nonspecific influence on the cell surface. As a result the HIV receptor is blocked.
Subject(s)
HIV-1/isolation & purification , T-Lymphocytes/microbiology , AIDS Serodiagnosis/methods , Depression, Chemical , HIV-1/drug effects , HIV-1/metabolism , Humans , Phenytoin , Protein Binding/drug effects , Receptors, HIV/drug effects , Receptors, HIV/metabolism , T-Lymphocytes/drug effects , T-Lymphocytes/metabolismABSTRACT
On the basis of analysis of a number of documents concerning the molecular mechanisms of actions of well-known drugs the first attempt has been made to subdivide their activities into traditional and nontraditional ones. The possibility of application of a number of well-known drugs to nontraditional fields of pharmacology has been demonstrated.
Subject(s)
Drug Therapy/trends , Pharmaceutical Preparations/classification , Pharmacology/trends , Humans , Structure-Activity RelationshipABSTRACT
The modern biological systems used for search for new safe drugs have been analyzed. An algorithm for analysis of experimental data has been proposed. It allows to predict the effect of a drug on a given individual.
Subject(s)
Models, Theoretical , Pharmacology , Predictive Value of Tests , Humans , Systems TheoryABSTRACT
Complicated ecological conditions, caused by wide and active application of artificial chemicals, makes it necessary to reveal their effect on human and animal organism and take measures for protecting health. The possibility to use advanced computing and information devices in combination with specialized methodical approaches allowed to elaborate and build a model of a system for revealing fine and multi-aspect influence of various factors on organisms of experimental animals. The results obtained allow to consider creation of similar systems a necessary and feasible task.
