Subject(s)
Antineoplastic Agents, Alkylating/history , Methylnitrosourea/history , Neoplasms/history , Animals , Antineoplastic Agents, Alkylating/administration & dosage , Antineoplastic Agents, Alkylating/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/history , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Female , History, 20th Century , Humans , Male , Methylnitrosourea/administration & dosage , Methylnitrosourea/therapeutic use , Neoplasms/drug therapy , Neoplasms/mortality , Randomized Controlled Trials as Topic/history , Russia , Time Factors , USSRABSTRACT
The paper discusses results of a cooperative study of effectiveness of hydrazine sulfate therapy in 740 patients with primary advanced, recurrent and metastatic solid tumors and malignant lymphomas who had failed all other treatment modalities. Both objective response and symptomatic effect were assessed. Objective response was observed in neuroblastoma, recurrent desmoid, Hodgkin's disease, lung cancer, fibrosarcoma and other tumors. Since hydrazine sulfate provided relief of a wide spectrum of cancer symptoms, it may be recommended for patients with end-stage cancer.
Subject(s)
Antineoplastic Agents/therapeutic use , Hydrazines/therapeutic use , Adolescent , Adult , Aged , Antineoplastic Agents/administration & dosage , Antineoplastic Agents/adverse effects , Drug Evaluation , Female , Humans , Hydrazines/administration & dosage , Hydrazines/adverse effects , Male , Middle Aged , Multicenter Studies as Topic , Neoplasm Recurrence, Local/drug therapy , Neoplasms/drug therapy , Remission Induction , Tablets, Enteric-Coated , Time FactorsSubject(s)
Antineoplastic Agents/therapeutic use , Lung Neoplasms/drug therapy , Adenocarcinoma/drug therapy , Adenocarcinoma/mortality , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Bleomycin/administration & dosage , Carcinoma, Small Cell/drug therapy , Carcinoma, Small Cell/mortality , Carcinoma, Squamous Cell/drug therapy , Carcinoma, Squamous Cell/mortality , Cyclophosphamide/administration & dosage , Doxorubicin/administration & dosage , Humans , Lomustine/administration & dosage , Lung Neoplasms/mortality , Mechlorethamine/administration & dosage , Vincristine/administration & dosageABSTRACT
Thirty cases of disseminated skin melanoma were treated with nitrosomethylurea which was given in 2-3 week courses (10 mg/kg twice a week each) at 1-2 month intervals. Complete response with a recurrence-free period of 6 months to over 3 years was registered in 3 patients (10%). A decrease in tumor size by more than 50% within 5-12 months was secured in 6 patients (20%). The responders survived longer than those in whom the treatment had failed. Side-effects were moderate and reversible. Nitrosomethylurea should be widely used in treatment of skin melanoma.
Subject(s)
Melanoma/drug therapy , Methylnitrosourea/therapeutic use , Nitrosourea Compounds/therapeutic use , Skin Neoplasms/drug therapy , Adult , Aged , Drug Evaluation , Female , Humans , Male , Melanoma/mortality , Methylnitrosourea/adverse effects , Middle Aged , Neoplasm Metastasis , Skin Neoplasms/mortality , Time FactorsSubject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Bone Neoplasms/secondary , Bone and Bones/drug effects , Breast Neoplasms , Doxorubicin/administration & dosage , Tamoxifen/administration & dosage , Adult , Bone Neoplasms/drug therapy , Bone and Bones/diagnostic imaging , Female , Humans , Middle Aged , RadiographySubject(s)
Melanoma/drug therapy , Skin Neoplasms/drug therapy , Adolescent , Adult , Aged , Drug Evaluation , Drug Therapy, Combination , Female , Humans , Male , Methylnitrosourea/administration & dosage , Middle Aged , Neoplasm Metastasis , Prospidium/administration & dosage , Time Factors , Vincristine/administration & dosageSubject(s)
Breast Neoplasms/drug therapy , Tamoxifen/therapeutic use , Aged , Female , Humans , Middle AgedABSTRACT
The author's experience with nitrosomethylurea+prospidine treatment in 37 patients having disseminated melanoma is described. The mentioned scheme of the combination therapy is proved to be effective.
