1.
Clin Pharmacol Ther
; 82(2): 137-42, 2007 Aug.
Article
in English
| MEDLINE
| ID: mdl-17632539
ABSTRACT
As the transition to model-based drug development continues, pharmacometric analysis will have an increasingly important role across the entire life cycle of drug discovery, development, regulatory approval, and commercialization. For this reason, pharmacometrics can--and should--have an integrating function in the transformation to model-based development. This essay describes an approach for formalizing the pharmacometrics process using the disciplines encompassed by enterprise engineering.