Decline in sperm count and motility in young adult men from 2003 to 2013: observations from a U.S. sperm bank.

Controversy exists regarding stability of semen quality over time with papers reporting decrease, increase or stable parameters in heterogeneous populations. The current study examined semen parameters of young adult men from 2003 to 2013 at an urban U.S. sperm bank. Semen parameters were analyzed before and after cryopreservation for a total of 9425 specimens from 489 individuals. Demographic information was obtained from a social and medical history questionnaire. Following 2-3 days abstinence, the specimens were collected at the laboratory and assessed by uniform technicians and techniques. The data were analyzed using generalized linear regression after adjustment for age, days of abstinence, for repeated samples, as well as by the Cochran-Armitage trend test. The within variability was accounted for by the repeated measures model. All p values were two-sided with p < 0.05 considered significant. There was a significant decline in sperm concentration (-3.55, 95% CI -4.87, -2.23; p < 0.001), total motility (-1.23, 95% CI -1.65, -0.82; p < 0.001), total count (-10.75, 95% CI -15.95, -5.54; p < 0.001) and total motile count (-9.43, 95% CI -13.14, -5.73; p < 0.001). There was no significant change in semen volume (0.03, 95% CI -0.02, 0.09; p = 0.2). The post-thaw total motility significantly (-2.30, 95% CI -2.72, -1.87; p < 0.001) decreased with time. Importantly, demographic and lifestyle factors were stable or improved over the study period. There was a decline in age (p(trend) = 0.003) and alcohol use (p(trend) = 0.005) and an increase in college GPA (Grade Point Average) (p(trend) = 0.02). BMI (p(trend) = 0.73), educational attainment (p(trend) = 0.2), race/ethnicity (p(trend) = 0.53), and lifestyle habits (weekly exercise, p(trend) = 0.21; smoking, p(trend) = 0.99; marital status, p(trend) = 0.85) remained constant. Uniform technicians and techniques over the study period make measurement bias unlikely. This report demonstrates a decline in semen quality among young adult men in the Boston area who were attending or completed a college education during the past 10 years, and requires further study.

Ajuga turkestanica increases Notch and Wnt signaling in aged skeletal muscle.

BACKGROUND: The declining myogenic potential of aged skeletal muscle is multifactorial. Insufficient satellite cell activity is one factor in this process. Notch and Wnt signaling are involved in various biological processes including orchestrating satellite cell activity within skeletal muscle. These pathways become dysfunctional during the aging process and may contribute to the poor skeletal muscle competency. Phytoecdysteroids are natural adaptogenic compounds with demonstrated benefit on skeletal muscle. AIM: To determine the extent to which a phytoecdysteroid enriched extract from Ajuga turkestanica (ATE) affects Notch and Wnt signaling in aged skeletal muscle. MATERIALS AND METHODS: Male C57BL/6 mice (20 months) were randomly assigned to Control (CT) or ATE treatment groups. Chow was supplemented with either vehicle (CT) or ATE (50 mg/kg/day) for 28 days. Following supplementation, the triceps brachii muscles were harvested and immunohistochemical analyses performed. Components of Notch or Wnt signaling were co-labelled with Pax7, a quiescent satellite cell marker. RESULTS: ATE supplementation significantly increased the percent of active Notch/Pax7+ nuclei (p = 0.005), Hes1/Pax7+ nuclei (p = 0.038), active B-catenin/Pax7+ nuclei (p = 0.011), and Lef1/Pax7+ nuclei (p = 0.022), compared to CT. ATE supplementation did not change the resting satellite cell number. CONCLUSIONS: ATE supplementation in aged mice increases Notch and Wnt signaling in triceps brachii muscle. If Notch and Wnt benefit skeletal muscle, then phytoecdysteroids may provide a protective effect and maintain the integrity of aged skeletal muscle.

The abundances of constituents of Titan's atmosphere from the GCMS instrument on the Huygens probe.

Saturn's largest moon, Titan, remains an enigma, explored only by remote sensing from Earth, and by the Voyager and Cassini spacecraft. The most puzzling aspects include the origin of the molecular nitrogen and methane in its atmosphere, and the mechanism(s) by which methane is maintained in the face of rapid destruction by photolysis. The Huygens probe, launched from the Cassini spacecraft, has made the first direct observations of the satellite's surface and lower atmosphere. Here we report direct atmospheric measurements from the Gas Chromatograph Mass Spectrometer (GCMS), including altitude profiles of the constituents, isotopic ratios and trace species (including organic compounds). The primary constituents were confirmed to be nitrogen and methane. Noble gases other than argon were not detected. The argon includes primordial 36Ar, and the radiogenic isotope 40Ar, providing an important constraint on the outgassing history of Titan. Trace organic species, including cyanogen and ethane, were found in surface measurements.

Toward an organizational-relational model of open adoption.

Clinicians and social scientists have attempted to demonstrate the advisability of open versus closed adoption (communication and/or contact vs. no communication and/or contact between biological and adoptive parents) from a variety of theoretical perspectives. In our article, we seek a conceptual framework that will (a) elaborate how such divergent conclusions about openness versus confidentiality have heretofore been drawn, and (b) provide a comprehensive analysis of the behavior and experiences of all members of the adoption triad (birthparents, adoptive parents, adoptees). Employing structural aspects of organismic-developmental theory (Werner, 1957) and dynamic aspects of self-in-relation theory (Miller, 1976), we propose an organizational-relational approach to open adoption. Preliminary research findings are also provided.

Correlations among field dependence-independence, sex, sex-role stereotype, and age of preschoolers.

Preschoolers (27 boys, mean age = 4.7 yr.; 24 girls, mean age = 4.6 yr.) were assessed for field dependence-independence (Preschool Embedded Figures Test), sex-role stereotyping (Sex-role Learning Inventory), and receptive verbal intelligence (Peabody Picture Vocabulary Test--Revised). Relative to the girls, the boys were significantly less field-independent and significantly more sex-role stereotyped. After age and Peabody IQs were partialled out by multiple regression, same-sex typing in boys and cross-sex typing in girls were significant predictors of field independence. The regression analysis also suggested that, by 5.3 yr. of age, the boys as a group surpassed the girls on field independence. Limitations of the present research and educational implications of the over-all findings are discussed.

Cherished possessions and adaptation of older people to nursing homes.

One hundred older people (75 females, 25 males), in nursing homes rated as above or below a combined criterion (based on Lieberman and Tobin's scales of physical attractiveness, affiliation fostering, and tolerance for deviancy), responded to questionnaires on cherished possessions and on adaptation to the nursing home. The main findings indicated: 1) relative to those residents without possessions, those with possessions were better adapted to the nursing home; 2) possessions served the major functions of historical continuity, comforter, and sense of belongingness; 3) relative to men, significantly more women had cherished possessions and were more likely to associate them with self-other relationships; and 4) relative to residents in nursing homes below the mean of the combined criterion, those in homes above the mean felt more in control, less helpless, more supported by staff, and were judged as more realistic in response to conflict. Interpretations regarding the role of possessions in adaptation and suggestions for institutional policies concerning possessions are discussed.

Open and closed adoption: a developmental conceptualization.

Given the annual increase in the multiple forms of adoptive practices within contemporary American society, research aimed at assessing the effects on the adoptees, their families, and the community of "open" versus "closed" adoption (communication versus no communication between biologic and adoptive parents) of healthy infants is sorely needed. Before this can be done, researchers and mental health professionals need to make sense of the myriad of findings in the adoption literature. With the goal of stimulating such research, the present article is comprised of: (a) a review of the contemporary, social scientific literature on adoption, which has focused for the most part on traditional, closed adoption; and (b) a description of a program of research on adoption that is generated from a theoretical orientation, which has already proven valuable in the examination of other developmental life transitions. Based on a holistic, developmental, systems orientation to person-in-environment functioning, this approach provides a developmental conceptualization of both open and closed adoption. Hopefully, the literature review and the research program described here will stimulate other investigators to conduct research on this important problem from their own perspective or from variations of research described in this article.

Case oriented group discussions for family physicians.

Curriculum in family medicine and primary care includes various areas of concern for educators in the behavioral sciences. Most of this concerns the physician-patient relationship as the focus for teaching and learning. This paper outlines the work of a longitudinal, case oriented group of family physicians as it reflects the correlation between the actualities of practice and the curriculum in behavioral science for family practice residents. Also discussed is the issue of potential "typologies" as elaborated in the family physicians' reasons for case presentations. Such groups assist faculty and practitioners in their own awareness of educational and patient care issues in the physician-patient relationship as well as serve as a foundation for building a relevant behavioral science curriculum for residents and students.