[State of the hypothalamo-hypophyseal neurosecretory system of rabbits following anaphylactic shock]. / Sostoianie gipotalamo-gipofizarnoi neirosekretornoi sistemy krolikov posle anafilakticheskogo shoka

The hypothalamo-hypophysial neurosecretory system of rabbits was investigated 1, 3, 7, 14, and 21 days after the anaphylactic shock. It was found morphometrically that dimensions of the nucleoli of the supraoptic and paraventricular nuclei gradually increased as compared with the moment of anaphylactic shock, but did not reach the control level. Restoration of the size of the nucleoli of the supraoptic nucleus was slower than of the paraventricular one. The quantity of the neurosecretory substance in all the system is significantly higher than in the control up to the end of the observation period (21 days). Thus, the intensity of the processes of synthesis and secretion of the neurohormones in the hypothalamo-hypophysial neurosecretory system was decreased for 21 days of the post-shock period.

State of the hypothalamic-pituitary neurosecretory system in rabbits with anaphylactic shock.

The hypothalamic-pituitary neurosecretory system of rabbits with anaphylactic shock was investigated by morphometric and histochemical methods. The volumes of the perikarya were increased and the dimensions of the nuclei and nuclei of the neurosecretory cells were reduced, and the content of neurosecretory substance throughout the neurosecretory system was increased. In rabbits dying from shock the volumes of the nuclei and nuclei were reduced by a lesser degree, the dimensions of the perikarya were changed, and the content of neurosecretory substance in the posterior lobe of the pituitary was reduced. In animals surviving shock the synthesis of neurohormones by the neurosecretory cells was thus sharply stimulated, but liberation of neurohormones from the posterior lobe was inhibited. In aminals dying from shock hormone formation in the neurosecretory cells was stimulated to a lesser degree, but the processes of liberation of neurohormones from the posterior lobe of the pituitary were probably intensified.

[State of the hypothalamo-hypophyseal neurosecretory system of rabbits in anaphylactic shock]. / Sostoianie gipotalamo-gipofizarnoi neirosekretornoi sistemy krolikov pri anafilakticheskom shoke

With the aid of morphometric and histochemical methods a study was made of the hypothalamo-hypophyseal neurosecretory system of rabbits in anaphylactic shock. The following occurred in rabbits which survived the shock: an enlargement of the perikarions and reduction in the size of the nuclei and nucleoli of the neurosecretory cells; the content of the neurosecretory substance was increased in the whole neurosecretory system. In rabbits which perished from shock the nuclei and the nucleoli of the neurosecretory cells diminished to a lesser extent, perikarion measurements remained unchanged and the content of the neurosecretory substance in the posterior lobe of the hypophysis fell. Thus, in the animals which survived the shock the processes of synthesis of the neurohormones by the neurosecretory cells were sharply activated, but the secretion of the neurohormones from the posterior lobe of the hypophysis was inhibited; in animals which perished from shock the activation of the hormone formation in the neurosecretory cells was less pronounced, but the processes of the secretion of the neurohormones from the posterior lobe were apparently intensified.