[Changes of cytokine levels in the serum in patients with acute pancreatitis as an early symptom for diagnosis]. / Zminy kontsentratsiï tsytokiniv syrovatky krovi na hostryi pankreatyt iak rannii diahnostychnyi kryterii.

Changes of concentration of proinflammatory cytokines--tumor necrosis factor (TNF), interleukin-1, growth transforming factor, granulocyte--macrophage colony stimulating factor in the blood serum of patients with probable diagnosis of an acute pancreatitis (AP) were examined. Seven days before the disease occurrence the TNF concentration rise was observed, what proved, by the authors opinion, its significance as an early diagnostic criterion for AP. Other diagnostic methods did not prove their information value in determination of the disease occurrence during the 7 day premorbid period.

[Complex treatment of patients with purulent-necrotic complications of diabetes mellitus]. / Kompleksne likuvannia khvorykh z hniino-nekrotychnymy uskladnenniamy tsukrovoho diabetu.

Biochemical, immunological investigations were performed in dynamics for identification of pathogenic microorganisms in the wound in 375 patients with complicated diabetes mellitus. Content of the APUD-system hormones was determined using radioimmune method. Conservative treatment included administration of insulinum pro injectionibus, plasm, albumin, rheopolyglycine, vitamins, antihypoxants, antibiotics, metronidazole, immunotherapy, dalargin, sandostatinum, D-phenylalanine. In preoperative and postoperative periods were widely applied measures of organism detoxication, physiotherapeutic methods. Original method of xenoskin was applied for closure of the wound and ulcerative defect. Application of proposed method of treatment had permitted to improve its result.