Near-Zero-Index Slabs on Bloch Surface Wave Platform for Long-Range Directional Couplers and Optical Logic Gates.

Near-zero-index materials and structures, with their extraordinary optical behaviors of phase-free propagation resulting in directional radiation, provide a possible approach for directional coupling and optical logic gates in photonic integrated circuits. However, the radiation from the near-zero-index structures is limited to a short range of a few hundreds of nanometers. A Bloch surface wave (BSW), an electromagnetic surface wave that can be excited at the interface between an all-dielectric multilayer and a dielectric medium with a low-loss optical mode, provides a solution to increase the propagation length. In this work, we present a nanostructured near-zero-index slab integrated on the all-dielectric metal-free BSW platform for long-range surface wave radiation. By employing the long-range directional surface-wave radiation, a directional coupler and optical logic gates based on the BSW near-zero-index slabs are realized. The proposed directional couplers achieve long coupling distances (the electric-field magnitude ratio between the input slab and output slab is 0.22 with a 50 µm coupling distance), which is 2 orders of magnitude longer than that of conventional directional couplers based on evanescent wave coupling. By controlling the interference pattern of the BSW between the slabs, the XOR logic gate is experimentally demonstrated with a significant extinction ratio of 27.9 dB at telecommunications wavelengths. The BSW near-zero-index logic gates and the directional coupler with long-range light propagation provide an approach to the development of photonic integrated circuits and metal-free surface wave-based applications.

A Smartphone-based Diffusometric Immunoassay for Detecting C-Reactive Protein.

In this study, we developed a portable smartphone-based diffusometry for analyzing the C-reactive protein (CRP) concentration. An optimized fluorescence microscopic add-on system for a smartphone was used to image the 300 nm fluorescent beads. Sequential nanobead images were recorded for a period and the image data were used for fluorescence correlation spectrometric (FCS) analysis. Through the analysis, the nanobeads' diffusion coefficient was obtained. Further, the diffusion coefficients of the anti-CRP-coated nanobeads, which were suspended in the samples with various CRP concentrations, were estimated using smartphone-based diffusometry. After 10 min of reaction, the anti-CRP-coated nanobeads in a higher CRP concentration solution led to a lower diffusion coefficient. Based on the experiments, a linear sensing range of 1~8 µg/mL was found.

A Novel Thermal Bubble Valve Integrated Nanofluidic Preconcentrator for Highly Sensitive Biomarker Detection.

In this study, we developed a new immunosensor that can achieve an ultralow detection limit and high sensitivity. This new device has an electrokinetic trapping (EKT)-based nanofluidic preconcentrator, which was integrated with oscillating bubble valves, to trap concentrated antigen and immunobeads. During the immunoassay process, oscillating bubbles rapidly grew and acted as control valves and to block the microchannel. Thereafter, the trapped preconcentrated antigen plug and antibody-coated nanobeads were preserved in the region between these two valves. Finally, the antigen concentration was quantitatively analyzed by a real-time measurement of Brownian diffusion of the immunobeads. In this work, the test sample used was C-reactive protein (CRP) which is a risk indicator of coronary heart disease and atherosclerosis.