[Different stimulation methods on auricular points for primary dysmenorrhea: a randomized controlled trial].

OBJECTIVE: To prove the therapeutic effect of auricular intradermal needling and auricular point sticking on primary dysmenorrhea (PD), and to explore its mechanism. METHODS: A total of 90 patients with PD were randomized into an auricular intradermal needling group, an auricular point sticking group and a placebo group, 30 cases in each one. Neishengzhiqi (TF2), Neifenmi (CO18), Shenmen (TF4), Shen (CO10), Jiaogan (AH6a), Gan (CO12) and Pizhixia (AT4) were selected in the 3 groups, intradermal needling and cowherb seed sticking were applied respectively in the auricular intradermal needling group and the auricular point sticking group, adhesive tape without needle was stuck in the placebo group. Pressing and kneading for 3 to 4 times were required each day, 3 to 4 min each time, and the intervention was started 5 d before menstruation, once every other day, 4 times each menstrual cycle were as one course, and totally 3 courses were required in the 3 groups. The follow-up was adopted at the next menstruation after treatment. The Cox menstrual symptom scale (CMSS) score, the visual analogue scale (VAS) score and the self-rating anxiety scale (SAS) score before treatment, 1,2,3 courses into treatment and at follow-up were compared, the serum levels of PGF2αand PGE2 before and after treatment were detected, and the clinical therapeutic effect was evaluated in the 3 groups. RESULTS: Compared before treatment, the scores of CMSS, VAS and SAS were decreased at each time point of treatment in the auricular intradermal needling group, 2, 3 courses into treatment and at follow-up in the auricular point sticking group and 3 courses into treatment in the placebo group (P<0.001, P<0.05). Compared with the auricular point sticking group, the CMSS scores at each time point of treatment and the VAS scores of 1, 2 courses and at follow-up were decreased in the auricular intradermal needling group (P<0.05). Compared with the placebo group, the CMSS scores were decreased at each time point of treatment in the auricular intradermal needling group and 3 courses into treatment and at follow-up in the auricular point sticking group (P<0.001, P<0.05); the VAS scores were decreased at each time point of treatment in the auricular intradermal needling group and the auricular point sticking group (P<0.001, P<0.05). After treatment, the serum levels of PGF2α were decreased (P<0.05) and the serum levels of PGE2 were increased (P<0.05) in the auricular intradermal needling group and the auricular point sticking group, and the serum levels of PGF2α were lower than the placebo group (P<0.05), the serum levels of PGE2 were higher than the placebo group (P<0.05) in the two groups. Compared with the auricular point sticking group, the serum level of PGF2 was decreased (P<0.05), the serum level of PGE2α was increased in the auricular intradermal needling group (P<0.05). The total effective rates were 93.3% (28/30) in the auricular intradermal needling group and 80.0% (24/30) in the auricular point sticking group, which were both superior to 63.3% (19/30) in the placebo group (P<0.05). CONCLUSION: Auricular intradermal needling and auricular point sticking can both improve the clinical symptom of primary dysmenorrhea, relieve the pain and anxiety, their mechanism may be related to regulating the serum levels of PGF2α and PGE2. The therapeutic effect of auricular intradermal needling is superior to auricular point sticking, and the placebo effect can be preliminarily excluded.

[Needle-embedding treatment for hemifacial spasm: research progress].

The articles regarding needle-embedding treatment for hemifacial spasm published before September 30, 2019 were searched from SinoMed, Wanfang, CNKI, VIP and PubMed database, and were analyzed and summarized from treatment methods, acupoint selection, stage differentiation and action mechanism. As a result, 45 Chinese articles were obtained. The needle-embedding treatment was divided into intradermal needling and acupoint thread-embedding; the top five acupoints were Sibai (ST 2), Taiyang (EX-HN 5), Dicang (ST 4), Jiache (ST 6) and spasm trigger points. The basic research of needle-embedding treatment for hemifacial spasm is weak, and the literature regarding stage differentiation is insufficient, which are in need of further study.

[Analysis of Peroxyacetyl Nitrate and Ozone During a Typical Photochemical Pollution Process at the Panyu Atmospheric Composition Station].

The typical photochemical pollution process in Guangzhou was analyzed from 2010 to 2016 by observing photochemical pollutants (ozone (O3), peroxyacetyl nitrate (PAN), volatile organic compounds (VOCs), nitrogen dioxide (NO2), and nitric oxide (NO)) and meteorological factors at the Guangzhou Panyu Atmospheric Composition Station (GPACS). The results showed that during this photochemical pollution process, the average O3 and PAN concentrations were relatively high:O3,max 1 h concentration was 140.6×10-9 and PANmax 1 h concentration was 4.7×10-9. The average concentration of NO was low, which had little effect on O3 titration and PAN elimination. The high NO2 concentration, strong radiation, and low wind speed all led to the formulation and accumulation of O3 and PAN. The linear relationship between O3 and PAN (R2=0.55) was affected by the fact that their precursor VOCs were not similar. Ethene, propane, isoprene, and toluene had a large influence in PAN formation, while isoprene, 1,3,5-trimethylbenzene, propene, m,p-xylene, and toluene had a large influence on O3 formation potential. When evaluating PA concentration, we found that its daily average concentration ranged from 0.11×10-12 to 0.16×10-12, which were higher than many places around the world, indicating that this photochemical process was relatively intensive.

[A Method of Aerosol Particle Number Size Distribution Inversed by PM2.5 Mass Concentration in PRD].

The aerosol particle number size distribution(PNSD) is of great importance in calculating atmospheric radiation and optics. It can effectively supplement the inadequate observation of PNSD using the widely known aerosol mass concentration (PM2.5) measurement to invert PNSD. It would be valuable for research that needs PNSD data, like atmospheric visibility calculation. This paper created a PNSD inversed method based on the statistics and parameterization of the dry aerosol PM2.5 and PNSD dataset from the Guangzhou urban site's simultaneous measurements from November 2014 to January 2015. The inversed results appeared good in the accumulation mode, whereas more differences showed with higher PM2.5 loading. The applicability and stability of this method makes it preferable. It would provide advanced technical support for the visibility calculation and application in PRD.

[Effect of VOCs on O3 and SOA Formation Potential During the Combined Pollution Process in Guangzhou Panyu Atmospheric Composition Station].

An analysis was made by using historical observational data of Guangzhou Panyu Atmospheric Composition Station(GPACS). The results showed that typical haze processes accompanied with high ozone episodes happened during the period from September 2rd, 2011 to September 5th, 2011(P1) and the period from June 12th, 2012 to June 15th, 2012(P2) respectively. During the two combined pollution processes (P1 and P2), daily visibility ranged from 5.78 km to 6.91 km and from 5.60 km to 9.25 km, and the maximum 8 h O3reached 92.14×10-9 and 91.29×10-9 respectively. Among the 55 detected volatile organic compounds(VOCs), alkenes and aromatics had the highest reactivity with the 41%, 39% proportions of equivalent propylene concentration and the proportions of 28%, 54% in the aspect of ozone formation potential during P1. Alkenes and aromatics contributed 35% and 46% of equivalent propylene concentration, as well as 22% and 61% to ozone formation potential during P2. In terms of SOA formation potential by FAC estimation, alkanes, alkenes and aromatics accounted for 13.2%, 21.4%, 65.4% during P1 and 4.6%, 13.8%, 81.6% during P2 respectively. Toluene, isoprene, ethylbenzene and m,p-Xylene had large contributions to the ozone and SOA formation. Factors including pollutants transported from the downtown area, continuous gentle wind, high temperature, low humidity and strong radiation gave rise to the occurrence of high ozone episodes in these two haze processes.

[Characteristics Analysis of Sulfur Dioxide in Pearl River Delta from 2006 to 2010].

Based on the in-situ SO2 observation dataset from 2006 to 2010 in Pearl River Delta(PRD) , the temporal characteristics of SO2 are analyzed. The results show that the annual average volume fraction of surface SO2 in 2010 declines to a level below average values in recent years, with reducing the frequency of high concentration episodes occurring. The seasonal, monthly and diurnal characteristics of surface SO2 are influenced by particular weather conditions in the PRD. The Probability Distribution Function(PDF) of surface SO2 volume fraction are complicated. The PDF is different every month maybe caused by the variation of the seasonal factors.

Simultaneous determination of borneol and its metabolite in rat plasma by GC-MS and its application to pharmacokinetic study.

A gas chromatography mass spectrometry (GC-MS) method has been developed and fully validated for the simultaneous determination of natural borneol (NB) and its metabolite, camphor, in rat plasma. Following a single liquid-liquid extraction, the analytes were separated using an HP-5MS capillary column (0.25 mm×30 m×0.25 µm) and analyzed by MS in the selected ion monitoring mode. Selected ion monitor (m/z) of borneol, camphor and internal standard was 95, 95 and 128, respectively. Linearity, accuracy, precision and extraction recovery of the analytes were all satisfactory. The method was successfully applied to pharmacokinetic studies of NB after oral administration to Wistar rats.

[Study on air quality and pollution meteorology conditions of Guangzhou during the 2010 Asian games].

Based on the monitoring data of NO2, O3, SO2, PM, visibility, regional air quality index (RAQI) and the atmospheric transport and diffusion data from Nov. 4, 2010 to Dec. 10, 2010 in Guangzhou area, the variations of air quality and meteorological conditions during the Guangzhou Asian Games were analyzed. It was found that, during the Asian Games, the air quality was better than the air quality before or after the Asian Games. The visibility was greater than the visibility before or after the Asian Games, while the concentrations of PM1 and PM2.5 were lower. The correlation coefficient between visibility and the concentrations of PM1, PM2.5 indicated anti-correlation relationships. Daily and hourly concentrations of NO2 and SO2 met the primary ambient air quality standards, whereas the daily concentration of PM10 and hourly concentration of O3 met the secondary ambient air quality standards. Pollutants had been well controlled during the Asian Games. The concentration of SO2 in Guangzhou was influenced by local sources and long distance transmission, while the concentration of NO2 was significantly influenced by local sources. The emissions of NO2, SO2 and PM10 surrounding Guangzhou had a trend to affect the concentrations in Guangzhou, but the situation of O3 was opposite, the relatively high concentration of O3 in Guangzhou had tendency to be transported to the surrounding areas. The pollution meteorology conditions in the period of Asian Games were better than the conditions before or after the Asian Games. The decrease in the concentrations during the Asian Games did not only benefit from the emission control by the government, but also from the good meteorological conditions.