An Artificial Neural Network to Eliminate the Detrimental Spectral Shift on Mid-Infrared Gas Spectroscopy.

We demonstrate the successful implementation of an artificial neural network (ANN) to eliminate detrimental spectral shifts imposed in the measurement of laser absorption spectrometers (LASs). Since LASs rely on the analysis of the spectral characteristics of biological and chemical molecules, their accuracy and precision is especially prone to the presence of unwanted spectral shift in the measured molecular absorption spectrum over the reference spectrum. In this paper, an ANN was applied to a scanning grating-based mid-infrared trace gas sensing system, which suffers from temperature-induced spectral shifts. Using the HITRAN database, we generated synthetic gas absorbance spectra with random spectral shifts for training and validation. The ANN was trained with these synthetic spectra to identify the occurrence of spectral shifts. Our experimental verification unambiguously proves that such an ANN can be an excellent tool to accurately retrieve the gas concentration from imprecise or distorted spectra of gas absorption. Due to the global shift of the measured gas absorption spectrum, the accuracy of the retrieved gas concentration using a typical least-mean-squares fitting algorithm was considerably degraded by 40.3%. However, when the gas concentration of the same measurement dataset was predicted by the proposed multilayer perceptron network, the sensing accuracy significantly improved by reducing the error to less than ±1% while preserving the sensing sensitivity.

Digital control of residual amplitude modulation at the 10-7 level for ultra-stable lasers.

The stabilization of lasers on ultra-stable optical cavities by the Pound-Drever-Hall (PDH) technique is a widely used method. The PDH method relies on the phase-modulation of the laser, which is usually performed by an electro-optic modulator (EOM). When approaching the 10-16 fractional frequency stability level, this technology requires an active control of the residual amplitude modulation (RAM) generated by the EOM in order to bring the frequency stability of the laser down to the thermal noise limit of the ultra-stable cavity. In this article, we report on the development of an active system of RAM reduction based on a free space EOM, which is used to perform PDH-stabilization of a laser on a cryogenic silicon cavity. A minimum RAM instability of 1.4 × 10-7 is obtained by employing a digital servo that stabilizes the EOM DC electric field, the crystal temperature and the laser power. Considering an ultra-stable cavity with a finesse of 2.5 × 105, this RAM level would contribute to the fractional frequency instability at the level of about 5 × 10-19, well below the state of the art thermal noise limit of a few 10-17.

Digital OPLL-based distributed Brillouin sensing system in optical fibers.

A digital optical phase-locked loop (OPLL) has been implemented to develop a distributed Brillouin sensing system in optical fibers. In our experiment, two commercial semiconductor lasers are phase-locked to each other with a highly flexible offset frequency using field programmable gate array (FPGA)-based electronics. Then, the difference frequency between the two lasers is highly stabilized and scanned by a desired step frequency in the vicinity of the Brillouin frequency of standard single-mode optical fibers. Consequently, the distribution of Brillouin frequency shift over a 50 km-long sensing fiber has been successfully measured by a very simple and low-cost Brillouin optical time-domain reflectometry (BOTDR) sensing system without any penalty in the sensing performance. The measurement repeatability at 50 km position of sensing fiber with a 5 m spatial resolution was measured be 4.5 MHz under fast measurement conditions: the number of trace averaging of 2000 and the frequency scan step of 12.8 MHz, showing the figure-of-merit of 3.0.

Digital Doppler-Cancellation Servo for Ultrastable Optical Frequency Dissemination Over Fiber.

Progress made in optical references, including ultrastable Fabry-Perot cavities, optical frequency combs, and optical atomic clocks, has driven the need for ultrastable optical fiber networks. Telecom-wavelength ultrapure optical signal transport has been demonstrated on distances ranging from the laboratory scale to the continental scale. In this article, we present a Doppler-cancellation setup based on a digital phase-locked loop (PLL) for ultrastable optical signal dissemination over fiber. The optical phase stabilization setup is based on a usual heterodyne Michelson-interferometer setup, while the software-defined radio (SDR) implementation of the PLL is based on a compact commercial board embedding a field-programmable gate array and analog-to-digital and digital-to-analog converters. Using three different configurations, including an undersampling method, we demonstrate a 20-m-long fiber link with residual fractional frequency instability as low as 10-18 at 1000 s and optical phase noise of -70 dBc/Hz at 1 Hz with a telecom frequency carrier.

Einstein-Podolsky-Rosen paradox in single pairs of images.

Spatially entangled twin photons provide a test of the Einstein-Podolsky-Rosen (EPR) paradox in its original form of position (image plane) versus impulsion (Fourier plane). We show that recording a single pair of images in each plane is sufficient to safely demonstrate an EPR paradox. On each pair of images, we have retrieved the fluctuations by subtracting the fitted deterministic intensity shape and then have obtained an intercorrelation peak with a sufficient signal to noise ratio to safely distinguish this peak from random fluctuations. A 95% confidence interval has been determined, confirming a high degree of paradox whatever the considered single pairs. Last, we have verified that the value of the variance of the difference between twin images is always below the quantum (poissonian) limit, in order to ensure the particle character of the demonstration. Our demonstration shows that a single image pattern can reveal the quantum and non-local behavior of light.

Upper limb evaluation and one-year follow up of non-ambulant patients with spinal muscular atrophy: an observational multicenter trial.

Assessment of the upper limb strength in non-ambulant neuromuscular patients remains challenging. Although potential outcome measures have been reported, longitudinal data demonstrating sensitivity to clinical evolution in spinal muscular atrophy patients are critically lacking. Our study recruited 23 non-ambulant patients, 16 patients (males/females = 6/10; median age 15.4 years with a range from 10.7 to 31.1 years) with spinal muscular atrophy type II and 7 patients (males/females = 2/5; median age 19.9 years with a range from 8.3 to 29.9 years) with type III. The Brooke functional score was on median 3 with a range from 2 to 6. The average total vital capacity was 46%, and seven patients required non-invasive ventilation at night. Patients were assessed at baseline, 6 months, and 1 year using the Motor Function Measure and innovative devices MyoGrip, MyoPinch, and MoviPlate, which assess handgrip strength, key pinch strength, and hand/finger extension-flexion function, respectively. The study demonstrated the feasibility and reliability of these measures for all patients, and sensitivity to negative changes after the age of 14 years. The younger patients showed an increase of the distal force in the follow-up period. The distal force measurements and function were correlated to different functional scales. These data represent an important step in the process of validating these devices as potential outcome measures for future clinical trials.

Upper limb strength and function changes during a one-year follow-up in non-ambulant patients with Duchenne Muscular Dystrophy: an observational multicenter trial.

INTRODUCTION: Upper limb evaluation of patients with Duchenne Muscular Dystrophy is crucially important to evaluations of efficacy of new treatments in non-ambulant patients. In patients who have lost ambulation, there are few validated and informative outcome measures. In addition, longitudinal data demonstrating sensitivity to clinical evolution of outcome measures over short-term periods are lacking. PATIENTS AND METHODS: We report here the results of a one-year multicenter study using specifically designed tools to assess grip, pinch strength, and hand function in wheelchair-bound patients. Our study assessed 53 non-ambulant patients with Duchenne muscular dystrophy aged 17.1 ± 4.8 years (range: 9 - 28.1 years). The average Brooke functional score of these patients was 4.6 ± 1.1. The average forced vital capacity was 44.5% predicted and 19 patients used non-invasive ventilation. Patients were assessed at baseline, 6 months, and one year using the Motor Function Measure and innovative devices (namely the MyoSet composed of MyoGrip, MyoPinch, and MoviPlate). RESULTS: Our study confirmed preliminary data previously reported regarding feasibility of use and of reliability of the MyoSet and the correlation at baseline between distal strength and clinical outcomes such as FVC, Brooke score, age, and duration since loss of ambulation. A significant correlation was observed between the distal upper limb strength and clinical variables. The sensitive dynamometers (MyoGrip and MyoPinch) and MoviPlate captured a 12-month change in non-ambulant Duchenne muscular dystrophy patients of all ages. TRIAL REGISTRATION: ClinicalTrials.gov NCT00993161 NCT00993161.