ABSTRACT
One of the main tasks of modern gerontology is isolation of the group of phenomena essential for aging from epiphenomenona accompanying them. The modern methods of simulation modeling may be the proper tool for correct isolation. The point of their application is reproduction of external aging manifestations in silico, and, in the first place, of standard survival curves with the help of the simplest internal mechanism. Such a mechanism seems to be the prime mover of aging. The aging model of one the most popular objects of experimental biology, a fruit fly Drosophila melanogaster created by us (http://winmobile.biz/moton/moto.html), is based on the assumption that the key mechanism of aging is cellularity loss, the speed of which is determined by the parameters of active oxygen forms generation in motoneurons.
Subject(s)
Aging/physiology , Computer Simulation , Longevity/physiology , Mitochondria/metabolism , Superoxide Dismutase/metabolism , Animals , Drosophila melanogaster/physiology , Humans , Models, BiologicalABSTRACT
HindIII fragments of chloroplast DNA of Pisum sativum L. and Arabidopsis thaliana L. of 0.7-kb size were cloned and sequenced. Comparative analysis of the primary structure of these DNA fragments with that of chloroplast DNA of Nicotianum tabacum L. revealed the presence of a part of the rps19 gene, exon 2 of the rpl2 gene, and the spacer. The sequence homology was evaluated in pairwise comparisons of coding and noncoding sequences, which revealed the specific features of the nucleotide sequences of the studied fragments.
Subject(s)
Arabidopsis/genetics , DNA/genetics , Fabaceae/genetics , Plants, Medicinal , Base Composition , Base Sequence , Chloroplasts/metabolism , Cloning, Molecular , Molecular Sequence Data , Sequence Homology, Nucleic AcidABSTRACT
A plasmid containing fragments of rp12 and rps19 genes from the chloroplast genome of Arabidopsis thaliana was developed. The presence of inverted repeats in the chloroplast DNA of A. thaliana and Vicia sativa, and their absence from two species of Fabaceae family (Lathyrus sativus, Lens esculenta) were shown with the help of this plasmid.
Subject(s)
Fabaceae/genetics , Genome , Plants, Medicinal , Arabidopsis/genetics , Arabidopsis/ultrastructure , Base Sequence , DNA/genetics , Fabaceae/ultrastructure , Molecular Sequence Data , Nucleic Acid Hybridization , Plasmids/genetics , Repetitive Sequences, Nucleic AcidABSTRACT
The study was concerned with the long-term results of local removal of villous tumors of large bowel in 144 cases. A statistical analysis of the treatment results versus such factors as patient's age, size and anatomical pattern of tumor, tumor invasion, villous tumor multiplicity and the concomittance of the latter with tubular adenoma of large bowel as well as the procedure of local removal furnished fresh evidence in support of local intervention provided tumor is free of invasive growth. Radical surgery should be indicated in cases of invasion or villous tumor growing per continuitatem.
Subject(s)
Adenoma/surgery , Colonic Neoplasms/surgery , Colonic Polyps/surgery , Adenoma/pathology , Colonic Neoplasms/pathology , Colonic Polyps/pathology , Colonoscopy , Follow-Up Studies , Humans , Neoplasms, Multiple Primary/pathology , Neoplasms, Multiple Primary/surgeryABSTRACT
The complex diagnosis of early forms of cancer of the large intestine should comprise the knowledge of the clinical picture, analysis of the disease, the results of rectoromanoscopy, irrogoscopy, colonofibroscopy, and cytological diagnosis. The use of the mentioned technics would help to improve the diagnosis of early forms of colonic cancer.
Subject(s)
Intestinal Neoplasms/diagnosis , Intestine, Large , Colon , Cytodiagnosis , Endoscopy , Humans , Intestinal Neoplasms/pathology , Intestine, Large/pathologySubject(s)
Colon , Colonic Neoplasms/surgery , Endoscopy , Intestinal Polyps/surgery , Adolescent , Adult , Aged , Colonic Neoplasms/classification , Colonic Neoplasms/diagnosis , Electrocoagulation , Fiber Optic Technology , Humans , Intestinal Polyps/classification , Intestinal Polyps/diagnosis , Middle AgedSubject(s)
Colonic Neoplasms/diagnosis , Rectal Neoplasms/diagnosis , Aged , Colon/pathology , Female , Humans , Male , Methods , Rectum/pathology , Time FactorsABSTRACT
The authors report 7000 gastroscopic investigations for various gastric lesions. In ulcerous disease with localization of ulcer in the stomach fibrogastroscopy permitted establishing the precise diagnosis in 91.18% of cases, whereas roentgenological studies - in 78.75%. Gastric polyps are also recognized rather more frequently (98.26%) while using gastroscopy than a roentgenological study. An application of fibrogastroscopy in the complex diagnosis of gastric lesions seems to be mandatory since it provides for the correct diagnosis in 100% of patients.
