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1.
Eur Phys J C Part Fields ; 77(12): 829, 2017.
Article in English | MEDLINE | ID: mdl-31997935

ABSTRACT

High-energy jets recoiling against missing transverse energy (MET) are powerful probes of dark matter at the LHC. Searches based on large MET signatures require a precise control of the Z ( ν ν ¯ ) +  jet background in the signal region. This can be achieved by taking accurate data in control regions dominated by Z ( ℓ + ℓ - ) +  jet, W ( ℓ ν ) +  jet and γ +  jet production, and extrapolating to the Z ( ν ν ¯ ) +  jet background by means of precise theoretical predictions. In this context, recent advances in perturbative calculations open the door to significant sensitivity improvements in dark matter searches. In this spirit, we present a combination of state-of-the-art calculations for all relevant V +  jets processes, including throughout NNLO QCD corrections and NLO electroweak corrections supplemented by Sudakov logarithms at two loops. Predictions at parton level are provided together with detailed recommendations for their usage in experimental analyses based on the reweighting of Monte Carlo samples. Particular attention is devoted to the estimate of theoretical uncertainties in the framework of dark matter searches, where subtle aspects such as correlations across different V +  jet processes play a key role. The anticipated theoretical uncertainty in the Z ( ν ν ¯ ) +  jet background is at the few percent level up to the TeV range.

2.
Eur J Pain ; 21(5): 843-854, 2017 05.
Article in English | MEDLINE | ID: mdl-27977070

ABSTRACT

BACKGROUND: The TRP channel ankyrin type 1 (TRPA1) is a nonselective cation channel known to be activated by environmental irritants, cold and endogenous mediators of inflammation. Activation of TRPA1 in trigeminal afferents innervating meningeal structures has recently been suggested to be involved in the generation of headaches. METHODS: Two in vitro models of meningeal nociception were employed using the hemisected rodent head preparation, (1) recording of single meningeal afferents and (2) release of calcitonin gene-related peptide (CGRP) from the cranial dura mater. The role of TRPA1 was examined using the TRPA1 agonists acrolein and mustard oil (MO). BCTC, an inhibitor of TRP vanilloid type 1 receptor channels (TRPV1), and the TRPA1 inhibitor HC030031 as well as mice with genetically deleted TRPA1 and TRPV1 proteins, were used to differentiate between effects. RESULTS: Acrolein did not cause discharge activity in meningeal Aδ- or C-fibres but increased the electrical activation threshold. Acrolein was also effective in releasing CGRP from the dura of TRPV1-/- but not of TRPA1-/- mice. MO increased the discharge activity of afferent fibres from rat as well as C57 wild-type and TRPA1-/- but not TRPV1-/- mice. The effect was higher in C57 compared to TRPA1-/- mice. CONCLUSION: Sole TRPA1 receptor channel activation releases CGRP and increases the activation threshold of meningeal afferents but does not generate propagated activity, and so would be capable of causing local effects like vasodilatation but not pain generation. In contrast, combined TRPA1 and TRPV1 activation may be rather pronociceptive supporting headache generation. SIGNIFICANCE: Sole activation of TRPA1 receptor channels increases the activation threshold but does not cause propagated action potentials in meningeal afferents. TRPA1 agonists cause CGRP release from rodent dura mater. Peripheral TRPA1 receptors may have a pronociceptive function in trigeminal nociception only in combination with TRPV1.


Subject(s)
Dura Mater/metabolism , Headache/metabolism , Nociception/physiology , Transient Receptor Potential Channels/metabolism , Animals , Calcitonin Gene-Related Peptide/metabolism , Male , Mice , Mice, Knockout , Nerve Fibers, Unmyelinated/metabolism , Rats , Rats, Wistar , TRPA1 Cation Channel , TRPV Cation Channels/genetics , TRPV Cation Channels/metabolism , Transient Receptor Potential Channels/genetics
3.
Phys Rev Lett ; 116(16): 161803, 2016 Apr 22.
Article in English | MEDLINE | ID: mdl-27152792

ABSTRACT

The first complete calculation of the next-to-leading-order electroweak corrections to four-lepton production at the LHC is presented, where all off-shell effects of intermediate Z bosons and photons are taken into account. Focusing on the mixed final state µ^{+}µ^{-}e^{+}e^{-}, we study differential cross sections that are particularly interesting for Higgs boson analyses. The electroweak corrections are divided into photonic and purely weak corrections. The former exhibit patterns familiar from similar W- or Z-boson production processes with very large radiative tails near resonances and kinematical shoulders. The weak corrections are of the generic size of 5% and show interesting variations, in particular, a sign change between the regions of resonant Z-pair production and the Higgs signal.

4.
Eur Phys J C Part Fields ; 75(8): 371, 2015.
Article in English | MEDLINE | ID: mdl-26300691

ABSTRACT

A comprehensive review of physics at an [Formula: see text] linear collider in the energy range of [Formula: see text] GeV-3 TeV is presented in view of recent and expected LHC results, experiments from low-energy as well as astroparticle physics. The report focusses in particular on Higgs-boson, top-quark and electroweak precision physics, but also discusses several models of beyond the standard model physics such as supersymmetry, little Higgs models and extra gauge bosons. The connection to cosmology has been analysed as well.

5.
Phys Rev Lett ; 106(5): 052001, 2011 Feb 04.
Article in English | MEDLINE | ID: mdl-21405384

ABSTRACT

Top-antitop quark pairs belong to the most abundantly produced and precisely measurable heavy-particle signatures at hadron colliders and allow for crucial tests of the standard model and new physics searches. Here we report on the calculation of the next-to-leading order (NLO) QCD corrections to hadronic W(+)W(-)bb production, which provides a complete NLO description of the production of top-antitop pairs and their subsequent decay into W bosons and bottom quarks, including interferences, off-shell effects, and nonresonant backgrounds. Numerical predictions for the Tevatron and the LHC are presented.

7.
Phys Rev Lett ; 103(1): 012002, 2009 Jul 03.
Article in English | MEDLINE | ID: mdl-19659136

ABSTRACT

We report on the calculation of the full next-to-leading-order QCD corrections to the production of ttbb final states at the LHC, which deliver a serious background contribution to the production of a Higgs boson (decaying into a bb pair) in association with a tt pair. While the corrections significantly reduce the unphysical scale dependence of the leading-order cross section, our results predict an enhancement of the ttbb production cross section by a K factor of about 1.8.

8.
Phys Rev Lett ; 99(16): 161803, 2007 Oct 19.
Article in English | MEDLINE | ID: mdl-17995240

ABSTRACT

Radiative corrections of strong and electroweak interactions are presented at next-to-leading order for the production of a Higgs boson plus two hard jets via weak interactions at the CERN Large Hadron Collider. The calculation includes all weak-boson fusion and quark-antiquark annihilation diagrams as well as the corresponding interferences. The electroweak corrections, which are discussed here for the first time, reduce the cross sections by 5% and thus are of the same order of magnitude as the QCD corrections.

13.
Phys Rev D Part Fields ; 51(9): 4738-4745, 1995 May 01.
Article in English | MEDLINE | ID: mdl-10018950
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