ABSTRACT
Histologic, histochemical and atomic absorption studies on liver tissue from 71 West Highland white terriers are reported. Twenty-seven dogs had histologically normal liver and copper concentration comparable to mongrel control dogs. Forty-four dogs had hepatic copper concentrations up to 22 times the mean copper concentration found in clinically normal mongrel dogs. Hepatitis, hepatic necrosis and cirrhosis were associated with the increased copper concentration in some dogs. Matings between dogs with high liver copper concentration produced pups with high liver concentration. The copper storage defect is inherited.
Subject(s)
Copper/metabolism , Dog Diseases/genetics , Liver/pathology , Metal Metabolism, Inborn Errors/veterinary , Aging , Animals , Copper/toxicity , Dog Diseases/pathology , Dogs , Female , Hepatitis/pathology , Liver/growth & development , Male , Metal Metabolism, Inborn Errors/genetics , Metal Metabolism, Inborn Errors/pathologyABSTRACT
Two strains of Rhipicephalus sanguineus acquired Ehrlichia canis by feeding as either larvae or nymphs on acutely infected dogs and, in subsequent instars, transmitted the agent to normal dogs. Three strains of R sanguineus transmitted E canis as adults after their larval and nymphal stages fed on infected dogs. More than 400 adult female ticks were fed on infected dogs as larvae or nymphs or both, but none transmitted E canis transovarially.
