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1.
Int J Surg Pathol ; 29(3): 289-293, 2021 May.
Article in English | MEDLINE | ID: mdl-32608312

ABSTRACT

E-cadherin is expressed in hematopoietic erythroid precursors, but to our knowledge, its expression in blastic plasmacytoid dendritic cell neoplasm (BPDCN) has not been described. We report a case of BPDCN showing strong expression of E-cadherin, arising in a patient with history of primary myelofibrosis. Four more cases of BPDCN tested all showed strong expression of E-cadherin. Lack of awareness of this pattern of expression may lead to erroneous diagnosis of acute erythroid leukemia. It is increasingly becoming important to correctly identify this group of neoplasms, as approved new anti-CD123-targeted therapies are becoming available.


Subject(s)
Antigens, CD/analysis , Bone Marrow/pathology , Cadherins/analysis , Dendritic Cells/pathology , Hematologic Neoplasms/diagnosis , Primary Myelofibrosis/pathology , Cell Transformation, Neoplastic , Diagnosis, Differential , Fatal Outcome , Female , Hematologic Neoplasms/pathology , Humans , Leukemia, Erythroblastic, Acute/diagnosis , Leukemia, Erythroblastic, Acute/pathology , Middle Aged , Primary Myelofibrosis/diagnosis
3.
Thromb Haemost ; 91(3): 522-30, 2004 Mar.
Article in English | MEDLINE | ID: mdl-14983228

ABSTRACT

The biphasic waveform that can predict for disseminated intravascular coagulation (DIC) is due to the formation of a calcium-dependent complex between C reactive protein (CRP) and very low density lipoprotein (VLDL). As thrombin generation is pivotal to DIC, this aspect has been specifically investigated and the VLDL component has been found to increase prothrombinase activity via both quantitative and qualitative changes. The specific prothrombinase activity of VLDL from patients manifesting the biphasic waveform was 2.5 times that of normal individuals or critically ill patients without the biphasic waveform. This activity was due to an increase in anionic phospholipid surfaces that could be inhibited with excess annexin V and which was dependent on structurally intact apolipoprotein B. The qualitative change appeared to be due to a deficiency of phosphatidylethanolamine in VLDL from patients with the biphasic waveform. The functional consequence of this enhanced prothrombinase activity was an increased procoagulant effect in plasma. Using a modified activated partial thromboplastin time assay, the mean normal clot time decreased significantly when VLDL from patients with biphasic waveforms was substituted. These results indicate that VLDL derived from patients with the biphasic waveform can enhance thrombin procoagulant activity. As the CRP-VLDL complex exists in vivo, it could have a pathogenic role in disseminating the process of intravascular coagulation.


Subject(s)
C-Reactive Protein/metabolism , Lipoproteins, VLDL/metabolism , Thromboplastin/metabolism , Adsorption , Annexin A5/pharmacology , Apolipoproteins B/metabolism , Blood Coagulation Tests , Cell Separation , Cerebrosides/metabolism , Chromatography, Thin Layer , Coagulants/metabolism , Disseminated Intravascular Coagulation , Dose-Response Relationship, Drug , Flow Cytometry , Humans , Immunosorbent Techniques , Lipoproteins/metabolism , Partial Thromboplastin Time , Phosphatidylethanolamines/metabolism , Protein Binding , Sepsis , Thrombin/metabolism , Time Factors , Triglycerides/metabolism
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