Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 37
Filter
1.
Eur J Prev Cardiol ; 27(5): 478-489, 2020 03.
Article in English | MEDLINE | ID: mdl-31597473

ABSTRACT

BACKGROUND: Co-morbid depression and anxiety symptoms are frequently under-recognised and under-treated in heart disease and this negatively impacts self-management. AIMS: The purpose of this study was to determine the prevalence, correlates and predictors of depression and anxiety in cardiac rehabilitation programmes, the impact of cardiac rehabilitation on moderate depression, anxiety and stress symptoms, and the relationship between moderate depression, anxiety and stress symptoms and cardiac rehabilitation adherence. METHODS: This was a retrospective cohort study of 5908 patients entering cardiac rehabilitation programmes from 2006-2017, across two Sydney metropolitan teaching hospitals. Variables included demographics, diagnoses, cardiovascular risk factors, medication use, participation rates, health status (Medical Outcomes Study Short Form-36) and psychological health (Depression Anxiety Stress Scales) subscale scores. RESULTS: Moderate depression, anxiety or stress symptoms were prevalent in 18%, 28% and 13% of adults entering cardiac rehabilitation programmes, respectively. Adults with moderate depression (24% vs 13%), anxiety (32% vs 23%) or stress (18% vs 10%) symptoms were significantly less likely to adhere to cardiac rehabilitation compared with those with normal-mild symptoms (p < 0.001). Anxiety (odds ratio 4.395, 95% confidence interval 3.363-5.744, p < 0.001) and stress (odds ratio 4.527, 95% confidence interval 3.315-6.181, p < 0.001) were the strongest predictors of depression. Depression (odds ratio 3.167, 95% confidence interval 2.411-4.161) and stress (odds ratio 5.577, 95% confidence interval 4.006-7.765, p < 0.001) increased the risk of anxiety on entry by more than three times, above socio-demographic factors, cardiovascular risk factors, diagnoses and quality of life. CONCLUSION: Monitoring depression and anxiety symptoms on entry and during cardiac rehabilitation can assist to improve adherence and may identify the need for additional psychological health support. Exploring the relevance and use of adjunct psychological support strategies within cardiac rehabilitation programmes is warranted.


Subject(s)
Anxiety/epidemiology , Cardiac Rehabilitation , Depression/epidemiology , Heart Diseases/rehabilitation , Secondary Prevention , Affect , Anxiety/diagnosis , Anxiety/psychology , Depression/diagnosis , Depression/psychology , Health Knowledge, Attitudes, Practice , Heart Diseases/diagnosis , Heart Diseases/epidemiology , Heart Diseases/psychology , Humans , Longitudinal Studies , New South Wales/epidemiology , Patient Compliance , Prevalence , Quality of Life , Retrospective Studies , Time Factors , Treatment Outcome
2.
Eur J Neurol ; 26(10): 1310-1317, 2019 10.
Article in English | MEDLINE | ID: mdl-31062440

ABSTRACT

BACKGROUND AND PURPOSE: Ischaemic stroke frequently has a cardioembolic (CE) source. Clinical and echocardiographic parameters associated with CE stroke were evaluated. METHODS: In all, 93 consecutive ischaemic stroke patients who underwent a transthoracic echocardiogram were retrospectively analysed; strokes were classified by TOAST (Trial of Org 10172 in Acute Stroke Treatment) criteria. Echocardiographic parameters related to CE stroke, including left atrial volumes and function, were compared to 73 healthy controls. RESULTS: Of 93 patients (mean age 66.1 years, 56% male), nine (10%) had large artery atherosclerosis, 38 (41%) CE stroke, two (2%) small vessel disease, two (2%) other and 42 (45%) undetermined aetiology. Left atrial (LA) maximum volumes (LAVImax ) and minimum volumes (LAVImin ) were larger in the CE group than the non-CE group (45 vs. 32 ml/m2 , 32 vs. 13 ml/m2 , respectively, P < 0.001), whilst LA function indices including LA emptying fraction and LA function index (LAFI) were lower in the CE group (34% vs. 55%, and 0.12 vs. 0.35, respectively, P < 0.001). Adjusting for clinical characteristics, LAFI ≤0.3 was an independent predictor of CE stroke (adjusted odds ratio 5.3, P = 0.001). Additionally, LAVImax and LAVImin were larger (61 vs. 44 and 32 vs. 24 ml/m2 respectively, P < 0.01) and LAFI significantly lower (0.34 vs. 0.52, P < 0.001) in the undetermined aetiology group versus healthy controls. CONCLUSIONS: Left atrial enlargement with reduced LA function was associated with CE stroke and LAFI was the best independent predictor. LA parameters were also altered in the undetermined aetiology group, suggesting an underlying LA myopathy in this subset.


Subject(s)
Brain Ischemia/pathology , Echocardiography/methods , Embolism/pathology , Heart Diseases/pathology , Stroke/pathology , Aged , Aged, 80 and over , Atherosclerosis/complications , Brain Ischemia/complications , Brain Ischemia/diagnostic imaging , Cardiomegaly , Cerebral Small Vessel Diseases/complications , Embolism/complications , Embolism/diagnostic imaging , Female , Heart Diseases/complications , Heart Diseases/diagnostic imaging , Heart Function Tests , Humans , Ischemic Attack, Transient/complications , Ischemic Attack, Transient/diagnostic imaging , Ischemic Attack, Transient/psychology , Male , Middle Aged , Retrospective Studies , Stroke/complications , Stroke/diagnostic imaging
3.
J Cardiovasc Surg (Torino) ; 54(4): 531-6, 2013 Aug.
Article in English | MEDLINE | ID: mdl-24013541

ABSTRACT

AIM: Composite arterial grafts using a T configuration from the left internal mammary artery (LIMA) are commonly used for coronary artery surgery. Little data exist regarding the use of saphenous vein (SV) in composite grafts from the LIMA. This study aimed to determine whether LIMA patency was reduced by the attachment of a SV T graft. METHODS: Patients (N.=166) who underwent coronary bypass surgery using the LIMA for SV graft inflow were identified from a database. Post discharge angiography was performed for investigation of symptoms or evidence of myocardial ischemia. Follow-up identified episodes of angiography, re-intervention and death. RESULTS: Complete follow-up was obtained in 165 patients, mean 6 years (0-16 years). The mean patient age was 70 years and 43 patients underwent concomitant procedures. In 25 patients who underwent post discharge angiography, the LIMA and T anastomoses were widely patent in 14 patients. The SV graft was occluded at the T anastomosis in 8 patients and the distal limb of the LIMA was occluded in 2 patients. In no patients were the vein and LIMA both occluded. CONCLUSION: The use of the LIMA for SV graft inflow does not appear to compromise the LIMA graft even when SV graft occlusion occurs.


Subject(s)
Coronary Artery Bypass/methods , Coronary Circulation , Coronary Vessels/surgery , Saphenous Vein/transplantation , Vascular Patency , Aged , Coronary Angiography , Coronary Artery Bypass/adverse effects , Coronary Artery Bypass/mortality , Coronary Vessels/diagnostic imaging , Coronary Vessels/physiopathology , Female , Graft Occlusion, Vascular/etiology , Graft Occlusion, Vascular/physiopathology , Humans , Kaplan-Meier Estimate , Male , Predictive Value of Tests , Risk Factors , Saphenous Vein/diagnostic imaging , Saphenous Vein/physiopathology , Time Factors , Treatment Outcome
4.
Qual Saf Health Care ; 16(6): 409-14, 2007 Dec.
Article in English | MEDLINE | ID: mdl-18055883

ABSTRACT

BACKGROUND: A collaborative is an effective method of implementing evidence-based practice across multiple sites through the sharing of experience and knowledge of others in a similar setting, over a short period of time. Collaborative methods were first used in the USA but have been adopted internationally. AIM: This paper sought to document the facilitators and barriers to the implementation of the collaborative method, based on a single site's experience of participating in a multisite, state-wide heart failure collaborative. METHOD: Qualitative data was collected using three complementary METHODS: participant observation, reflective journalling and key informant interviews. Quantitative monitoring of team performance occurred monthly according to prespecified performance indicators. FINDINGS: Barriers and facilitators that were identified by this study included: organisational factors, team composition, dynamics and networking, changing doctor behaviour, clinical leadership and communication. CONCLUSION: The findings from this study underscore the importance of leadership, communication and team cohesion for the successful implementation of the collaborative method at individual sites. In addition, the importance of a preparatory stage that deals with known barriers and facilitators to the collaborative method before the commencement of the official study period was highlighted. The potential for the collaborative approach to improve clinical outcomes warrants further systematic evaluation of process issues and consideration of the barriers and facilitators to implementation in various settings.


Subject(s)
Biomedical Research/organization & administration , Cooperative Behavior , Heart Failure/therapy , Interdisciplinary Communication , Leadership , Multicenter Studies as Topic , Outcome Assessment, Health Care/organization & administration , Chronic Disease , Evidence-Based Medicine , Group Processes , Heart Failure/drug therapy , Heart Failure/rehabilitation , Humans , Models, Organizational , New South Wales , Program Evaluation
5.
Heart Lung ; 28(3): 175-85, 1999.
Article in English | MEDLINE | ID: mdl-10330213

ABSTRACT

OBJECTIVE: Nurses have been performing exercise stress tests (EST) without medical supervision since 1978 in our hospital-based cardiac rehabilitation unit. This study was conducted to examine the incidence of cardiovascular complications and to describe the competency-based training program for the nurses performing the EST. DESIGN: Descriptive, retrospective audit of prospective data. SETTING: Single comprehensive cardiac rehabilitation center in a large tertiary referral hospital in western Sydney, Australia. SUBJECTS: Seventeen thousand, four hundred and sixty-seven patients were included in this study over a 12-year period. METHOD: Data were collected on all ESTs performed by the cardiac rehabilitation nurses from January 1986 to December 1997 in relation to serious cardiovascular complications and other EST parameters. RESULTS: In this study, 17,467 ESTs were performed on 5054 patients who had 6273 separate presentations. The most common entry diagnosis was after an acute myocardial infarction (50%). The mean age was 58 +/- 10.5 years (range 15 to 87 years; 80% male). The left ventricular ejection fraction (n = 2822) was 49% +/- 14%. In a subgroup analysis of 14,454 patients, 14% had a positive EST (ST segment >1.9 mm depression). There were no deaths associated with the EST, and there were 13 major complications in 12 patients. This figure included no cardiac arrests, 11 episodes of conscious sustained ventricular tachycardia, 1 reinfarction, and 1 mitral valve rupture, representing a 0% mortality rate and a 0.075% major morbidity rate. CONCLUSION: This study shows that nurse-supervised EST of higher risk patients in the hospital-based cardiac rehabilitation setting has been a safe practice from a mortality and morbidity rate perspective. This finding may be accounted for by the high training standard and reaccreditation of the nurses on the advanced practice of performing EST.


Subject(s)
Exercise Test/nursing , Myocardial Ischemia/diagnosis , Nursing Audit , Risk Management , Adolescent , Adult , Aged , Aged, 80 and over , Cerebrovascular Disorders/epidemiology , Cerebrovascular Disorders/etiology , Exercise Test/adverse effects , Female , Heart Diseases/epidemiology , Heart Diseases/etiology , Humans , Male , Middle Aged , Morbidity , Mortality , Myocardial Ischemia/rehabilitation , New South Wales/epidemiology , Retrospective Studies
6.
Int J Cardiol ; 35(2): 211-7, 1992 May.
Article in English | MEDLINE | ID: mdl-1572741

ABSTRACT

This study examined the role of electrophysiologic study in the evaluation of patients with unexplained syncope. The incidence of abnormalities (conduction disease, supraventricular tachycardia, ventricular tachycardia) was compared in patient groups with and without heart disease, and the effect of treatment of these abnormalities on recurrence of syncope was examined. Electrophysiologic study was performed in 111 consecutive patients with syncope, with antiarrhythmic medications being discontinued 1 week prior to study. There was no mortality associated with the procedure and only 9 patients (8%) had complications (groin haematoma, atrial fibrillation or brady-arrhythmias persisting after the procedure). Abnormalities were detected in 31 of 73 patients with heart disease (42%) but in only 6 of 38 patients with no heart disease (16%, P less than 0.01). During follow-up, syncope recurred in 2 of 37 patients (5%) treated because of abnormal findings, compared with a recurrence rate of 24% (18 of 74 patients) in the untreated group (P less than 0.05). Probability of remaining free from syncope at 2 years was 0.94 in the treated group and 0.72 in the untreated group (P less than 0.05). Mortality during follow-up was confined to the heart disease group with 5 of 30 treated patients in this group dying (17%) compared with 3 of 43 untreated patients (7%, P = not significant). Syncope patients with heart disease were thus more likely to have a diagnostically useful study than patients with normal hearts. Treatment directed at correction of abnormalities detected at electrophysiologic study reduced recurrence of syncope but did not significantly affect mortality. Syncope did not appear to be a prelude for sudden death in patients with normal hearts. Electrophysiologic study had no mortality and low morbidity.


Subject(s)
Syncope/physiopathology , Adolescent , Adult , Aged , Arrhythmias, Cardiac/complications , Arrhythmias, Cardiac/physiopathology , Cardiac Catheterization , Child , Electrophysiology , Female , Follow-Up Studies , Heart Diseases/complications , Heart Diseases/physiopathology , Humans , Male , Middle Aged , Recurrence , Syncope/etiology
7.
Can J Cardiol ; 6(1): 31-7, 1990.
Article in English | MEDLINE | ID: mdl-2310993

ABSTRACT

This study examined the effect of the long acting calcium antagonist anipamil on the extent of myocardial necrosis during 24 h of coronary artery occlusion in the dog. Forty dogs had coronary artery occlusion with a 2 mm embolus injected into the left coronary system; 141 cerium microspheres were used to delineate the ischemic zone immediately following occlusion. Twenty dogs received no drug (controls) and 20 received anipamil (two boluses of 0.25 mg/kg intravenously, one within 5 mins of occlusion and the other 12 h later). Arterial pressure and heart rate were monitored for 24 h. A subgroup of five controls and four anipamil treated dogs had injections of a second microsphere (113 tin or 46scandium) at 24 h to show changes in bloodflow. At 24 h the surviving dogs were sacrificed, their hearts sectioned, the risk zones delineated by autoradiography and the necrotic zones delineated by tetrazolium staining. Samples were taken from the normal myocardium and the risk zones for a determination of tissue anipamil content and measurement of regional bloodflow. In the control hearts, 76 +/- 4% of the risk zones became necrotic after 24 h, compared with 53 +/- 4% in the anipamil treated group (P less than 0.005). Anipamil had no effect on the heart rate or the arterial pressure. In the control dogs, the bloodflow to the tissue that became necrotic was 17% of the normal flow immediately after coronary occlusion, and 16% at 24 h; flow in the viable (subepicardial) tissue was also unchanged (49 versus 54%).(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Calcium Channel Blockers/pharmacology , Myocardial Infarction/drug therapy , Propylamines/pharmacology , Animals , Coronary Circulation/drug effects , Delayed-Action Preparations , Dogs , Hemodynamics/drug effects , Male , Myocardial Infarction/physiopathology , Necrosis , Propylamines/metabolism , Regional Blood Flow/drug effects
8.
J Mol Cell Cardiol ; 21(7): 651-60, 1989 Jul.
Article in English | MEDLINE | ID: mdl-2552129

ABSTRACT

This study examined the characteristics and distribution of sarcolemmal and light vesicular beta-adrenergic receptors (BAR) in left ventricular myocardium from 15 adults (aged 17 to 58 years) without left ventricular dysfunction or coronary artery disease and 29 patients (aged 14 to 53 years) with end-stage congestive heart failure (CHF). Sarcolemmal and intracellular fractions were prepared by 40,000 x g and 108,000 x g centrifugation, respectively. Agonist and antagonist binding properties were assessed by nonlinear computer modelling of isoproterenol-125I-pindolol (IPIN) displacement curves. Adenylate cyclase activity was also examined. Distribution of intracellular and sarcolemmal BAR was similar in normal and failing left ventricular myocardium, with intracellular BAR comprising 4.5 +/- 2.2% of total BAR in normal human heart and 5.7 +/- 5.1% of total BAR in CHF patients. For sarcolemmal BAR, antagonist affinity was similar for normal and CHF patients (KD IPIN in normals, 21.7 +/- 2.6 pM; KD IPIN in CHF, 20 +/- 2.3 pM). Agonist affinity was somewhat higher in CHF patients (KD isoproterenol in normals, 33 +/- 4.9 nM; KD isoproterenol in CHF, 6.2 +/- 1.5 nM). Sarcolemmal BAR number was reduced in CHF from 21.4 +/- 2.9 to 16.4 +/- 1.3 fmol/mg protein (P less than 0.04). Cyclic AMP production (pmol/mg protein/min above basal) was less in CHF after Gpp(NH)p stimulation (normals, 82 +/- 20; CHF, 27 +/- 9; P less than 0.01) and after stimulation with Gpp(NH)p + isoproterenol (normals, 129 +/- 25; CHF, 56 +/- 13; P less than 0.02). Stimulation with manganese + forskolin resulted in similar levels of cyclic AMP production in normals and in CHF patients. We conclude that: (a) sarcolemmal BAR number is reduced in CHF, but BAR are not redistributed intracellularly and (b) beta-adrenergic transmembrane signalling in CHF is also impaired at the level of the guanine nucleotide regulatory proteins.


Subject(s)
Adenylyl Cyclases/metabolism , GTP-Binding Proteins/metabolism , Heart Failure/metabolism , Heart Ventricles/metabolism , Receptors, Adrenergic, beta/metabolism , Adolescent , Adult , Binding, Competitive , Humans , Isoproterenol/metabolism , Middle Aged , Pindolol/metabolism
9.
J Cardiovasc Pharmacol ; 14(1): 6-13, 1989 Jul.
Article in English | MEDLINE | ID: mdl-2475717

ABSTRACT

We previously showed that combined treatment with allopurinol plus verapamil had a salutary effect on tissue necrosis during 24-h permanent coronary occlusion. The present study was undertaken to determine whether cardioprotection with allopurinol plus verapamil as compared with either allopurinol or verapamil treatment alone could be sustained in dog hearts during 48-h permanent coronary occlusion. In 46 dogs, coronary occlusion was induced using a closed-chest embolization procedure. Four groups were studied: (a) untreated controls, (b) dogs receiving allopurinol, (c) dogs receiving verapamil, and (d) dogs receiving allopurinol plus verapamil. Tissue necrosis was evaluated using triphenyltetrazolium staining and was related to two major baseline predictors of infarct size: anatomic risk zone size and coronary collateral flow. In untreated controls, the ratio of infarct to risk zone was inversely related to coronary collateral flow; analysis of covariance (ANCOVA) indicated that treatment with allopurinol or verapamil alone and combined allopurinol plus verapamil shifted this relationship downward. In conclusion, combined treatment with allopurinol plus verapamil did not afford additional limitation of tissue necrosis as compared with either allopurinol or verapamil treatment alone; however, considerable and statistically significant limitation of tissue necrosis was observed even during 48-h permanent coronary occlusion without reperfusion.


Subject(s)
Allopurinol/pharmacology , Myocardial Infarction/physiopathology , Myocardium/pathology , Verapamil/pharmacology , Animals , Calcium/metabolism , Coronary Circulation/drug effects , Dogs , Free Radicals , Hemodynamics/drug effects , Male , Myocardial Infarction/drug therapy , Myocardial Infarction/pathology , Necrosis , Oxygen Consumption
10.
Circulation ; 79(5): 1028-34, 1989 May.
Article in English | MEDLINE | ID: mdl-2540921

ABSTRACT

To test the hypothesis that there is up-regulation of beta-adrenergic receptor density or supersensitivity of beta-adrenergic receptor-stimulated adenylate cyclase in the denervated transplanted human heart, we studied myocardium from transplanted, normal, and failing hearts. Myocardium was obtained from 10 patients 9 +/- 3 months after cardiac transplantation, from 10 patients without cardiac disease, and from eight patients with symptomatic congestive heart failure due to idiopathic cardiomyopathy. beta-Adrenergic receptor density in transplanted myocardium (15 +/- 3 fmol/mg protein, 1.20 +/- 0.14 fmol/mg DNA) was not different from that in normal myocardium (22 +/- 3 fmol/mg protein, 1.46 +/- 0.13 fmol/mg DNA; p = NS for both). In myocardium from cardiomyopathic hearts, beta-adrenergic receptor density was markedly reduced (8 +/- 2 fmol/mg protein, 0.84 +/- 0.13 fmol/mg DNA; p less than 0.05 and p less than 0.01 vs. normal myocardium, respectively). Likewise, the response of adenylate cyclase to isoproterenol in transplanted myocardium was not significantly different from that in normal myocardium, but the response was markedly depressed in cardiomyopathic myocardium. Although forskolin-stimulated adenylate cyclase activity was similar in all three groups, guanine nucleotide-stimulated adenylate cyclase activity was markedly reduced in transplanted myocardium (20 +/- 17 vs. 78 +/- 13 pmol/mg/min for normal myocardium, p less than 0.01) and to a lesser degree in cardiomyopathic myocardium (39 +/- 14 pmol/mg/min, p less than 0.03 vs. normal myocardium). Thus, there is no evidence of beta-adrenergic receptor up-regulation or supersensitivity in denervated transplanted human myocardium.(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Adenylyl Cyclases/metabolism , Cardiomyopathy, Dilated/pathology , Heart Transplantation , Myocardium/enzymology , Receptors, Adrenergic, beta/analysis , Adolescent , Adult , Endocardium/pathology , Heart/innervation , Humans , Isoproterenol/pharmacology , Middle Aged , Myocardium/pathology , Receptors, Adrenergic, beta/physiology
11.
Circ Res ; 64(1): 155-66, 1989 Jan.
Article in English | MEDLINE | ID: mdl-2909298

ABSTRACT

This study examined electrophysiological and anatomic differences between dogs with ventricular tachycardia (VT) and fibrillation (VF) inducible by programmed ventricular stimulation 7-21 days after left anterior descending coronary artery ligation. Of 106 dogs studied, 40 had inducible VT, 19 had inducible VF, and 47 had no inducible arrhythmias. Differences between these three groups of animals were examined with cardiac mapping (to determine ventricular activation time in sinus rhythm) and post-mortem pathology (to measure infarct size and to reconstruct the anatomy at the infarct edge). Animals with inducible VT had longer maximal epicardial activation time (127 +/- 8 msec) than did animals with inducible VF (91 +/- 8 msec, p less than 0.05) or animals with no inducible arrhythmias (75 +/- 2 msec, p less than 0.001). Delayed epicardial activation occurred in 90% of animals with VT, 42% of animals with VF, and in only 6% of animals with no inducible arrhythmias. Endocardial and myocardial activation times were similar for the VT and VF groups. Infarct size was 18 +/- 2% of the ventricles for the VT group, much higher than for the VF group (11 +/- 2%, p less than 0.001) or for the group with no inducible arrhythmias (9 +/- 1%, p less than 0.001). The maximum diameter of viable muscle bundles interdigitating with scar tissue at the infarct edge was much larger in animals with VT (2.4 +/- 0.2 mm) than in animals with VF (1.8 +/- 0.2 mm, p less than 0.05) or animals with no inducible arrhythmias (1.7 +/- 0.1 mm, p less than 0.01). Thus, when compared with animals with inducible VF, animals with inducible VT had longer epicardial activation time, larger infarct size and viable muscle bundles of larger diameter at the infarct edge.


Subject(s)
Myocardial Infarction/physiopathology , Tachycardia/physiopathology , Ventricular Fibrillation/physiopathology , Animals , Cardiac Pacing, Artificial , Chronic Disease , Dogs , Electrophysiology , Female , Heart/physiopathology , Image Processing, Computer-Assisted , Male , Myocardial Infarction/complications , Myocardial Infarction/pathology , Myocardium/pathology , Tachycardia/etiology , Tachycardia/pathology , Ventricular Fibrillation/etiology , Ventricular Fibrillation/pathology
12.
Basic Res Cardiol ; 84(1): 5-12, 1989.
Article in English | MEDLINE | ID: mdl-2923606

ABSTRACT

UNLABELLED: This study examined the effects of 2% halothane general anesthesia on ventricular electrophysiological properties and inducibility of sustained ventricular tachycardia (VT) and ventricular fibrillation (VF). Dogs with chronic anterior infarction and control dogs (no infarction) were studied before and after anesthesia using chronically implanted ventricular epicardial electrodes. PQ interval was increased by 15% with halothane, but QRS duration, QT interval, QTc, and sinus rhythm cycle length were unaffected by anesthesia. Diastolic threshold was unchanged by halothane. Halothane caused significant increases of 10-30% in ventricular effective refractory period (ERP) both in control and in infarct animals. VT and VF were not inducible in any of the nine control animals either before or after anesthesia. In infarct animals 34 of 75 (45%) had inducible VT or VF prior to halothane, but the incidence of inducible arrhythmias was significantly lower at 29% (22 of 75 animals) after halothane (p less than 0.01). In 75% of animals in which halothane suppressed inducibility of tachyarrhythmias, halothane-induced increases in ERP prevented achievement of the short extrastimulus coupling intervals at which the arrhythmias were induced before anesthesia. IN CONCLUSION: halothane anesthesia reduces the incidence of inducible sustained ventricular tachyarrhythmias in chronic canine myocardial infarction.


Subject(s)
Cardiac Pacing, Artificial , Halothane/pharmacology , Myocardial Infarction/physiopathology , Tachycardia/physiopathology , Ventricular Fibrillation/physiopathology , Anesthesia, General , Animals , Diastole/drug effects , Dogs , Electrocardiography , Heart Ventricles/physiopathology , Myocardial Infarction/complications , Refractory Period, Electrophysiological/drug effects , Tachycardia/etiology , Ventricular Fibrillation/etiology
14.
Eur Heart J ; 9(7): 746-57, 1988 Jul.
Article in English | MEDLINE | ID: mdl-3169044

ABSTRACT

Survivors of acute myocardial infarction who had inducible sustained ventricular tachyarrhythmias at programmed stimulation 1-4 weeks after infarction were recruited to a randomized pilot trial of Class I antiarrhythmic drugs, in an attempt to determine whether their mortality and risk of spontaneous ventricular tachycardia and fibrillation could be reduced by treatment. Of 136 eligible patients, 96 (71%) joined the trial and 47 were randomized to 'no treatment' and 49 were randomized to 'treatment' (quinidine, disopyramide or mexiletine given to attain 'therapeutic' serum levels). During follow-up, the two groups fared similarly. For the 'treatment' and 'no treatment' groups, the respective 3-year probabilities of remaining incident-free were:cardiac death, 0.91 vs 0.89; instantaneous death + non-fatal ventricular tachyarrhythmias, 0.87 vs 0.87; cardiac death + non-fatal ventricular tachyarrhythmias, 0.83 vs 0.85. The highest risk patients with inducible ventricular tachycardia fared similarly in the 'treatment' and 'no treatment' groups. The respective probabilities of remaining incident-free were: cardiac death, 0.89 vs 0.88; instantaneous death + non-fatal ventricular tachyarrhythmias, 0.79 vs 0.84; cardiac death + non-fatal ventricular tachyarrhythmias, 0.76 vs 0.77. We conclude that prophylactic Class I antiarrhythmic drug therapy with quinidine, disopyramide or mexiletine given to achieve a 'therapeutic' serum level does not appear to alter the prognosis of patients with inducible ventricular tachyarrhythmias after myocardial infarction.


Subject(s)
Anti-Arrhythmia Agents/therapeutic use , Arrhythmias, Cardiac/prevention & control , Myocardial Infarction/complications , Actuarial Analysis , Aged , Anti-Arrhythmia Agents/blood , Arrhythmias, Cardiac/etiology , Disopyramide/blood , Disopyramide/therapeutic use , Electric Stimulation , Electrocardiography , Heart Ventricles/physiopathology , Humans , Mexiletine/blood , Mexiletine/therapeutic use , Myocardial Infarction/mortality , Prognosis , Quinidine/blood , Quinidine/therapeutic use , Random Allocation
15.
J Am Coll Cardiol ; 11(6): 1260-7, 1988 Jun.
Article in English | MEDLINE | ID: mdl-3367000

ABSTRACT

This study examined the effect of repeating the delivery of a programmed extrastimulus that previously failed to induce ventricular tachycardia, without the usual practice of concurrently altering other stimulation variables such as pacing site or basic cycle length. The impact of such repetition on both sensitivity and day to day variability in mode of arrhythmia induction was assessed in 24 patients with documented sustained ventricular tachycardia or fibrillation. Programmed stimulation in the absence of drugs was performed in each patient on 3 separate days. In the first 12 patients, each extrastimulus was scanned through diastole to refractoriness four times if no ventricular tachyarrhythmia was induced (longitudinal repetition); in the second 12 patients, each extrastimulus was delivered four times at a particular coupling interval before the interval was decreased in 10 ms steps to a closer coupling interval (lateral repetition). Day to day reproducibility of the mode of arrhythmia induction was compared with reproducibility in a control group of 18 similar patients studied previously on 3 separate days without repetition. A sustained ventricular tachyarrhythmia was inducible in all studies with four or fewer extrastimuli. In the group studied with longitudinal repetition, there was a 25% increased yield of induced ventricular tachycardia due solely to repetition of each extrastimulus scan, and the 95% confidence limit for tachycardia induction with any extrastimulus was achieved by delivering that extrastimulus three times. In the group studied with lateral repetition, there was also an increased yield of induced ventricular tachycardia at any extrastimulus coupling interval achieved by repetitive delivery of that coupling interval.(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Cardiac Pacing, Artificial , Tachycardia/physiopathology , Aged , Arrhythmias, Cardiac/physiopathology , Female , Heart Ventricles , Humans , Male , Middle Aged
16.
J Clin Invest ; 81(4): 1103-10, 1988 Apr.
Article in English | MEDLINE | ID: mdl-2832444

ABSTRACT

We infused dobutamine into the left main coronary artery of 24 patients with severe congestive heart failure (CHF) and 8 normal subjects without hemodynamic dysfunction. The maximal +dP/dt response to intracoronary (IC) dobutamine in CHF patients was only 37% of that in normals. This decrease in maximal response was not associated with a rightshift in the EC50 for dobutamine's effect on +dP/dt, or a decrease in the affinity of myocardial beta adrenergic receptors for dobutamine determined in vitro. In nine of the CHF patients, IC dobutamine infusion was followed by IC infusion of the phosphodiesterase inhibitor milrinone, and subsequently, by a second IC infusion of dobutamine. After IC milrinone, the increase in +dP/dt caused by IC dobutamine (74 +/- 10%) was significantly greater than that caused by the first infusion of dobutamine (52 +/- 11%; P less than 0.003) or milrinone (42 +/- 6%; P less than 0.001). Resting plasma norepinephrine was markedly elevated in CHF patients (837 +/- 208 ng/liter), but not in normal subjects (142 +/- 32 ng/liter); and the increase in +dP/dt caused by IC dobutamine was inversely related to resting plasma norepinephrine levels (r = -0.653; P less than 0.001). IC dobutamine caused a dose-related decrease in plasma norepinephrine (maximal effect, -160 +/- 31 ng/liter; P less than 0.001). Thus, (a) the maximal inotropic response to dobutamine is markedly depressed in patients with severe CHF, and is significantly greater after pretreatment with the phosphodiesterase inhibitor milrinone; (b) the impairment in inotropic response to dobutamine is inversely related to circulating norepinephrine levels; and (c) myocardial stimulation by dobutamine results in withdrawal of sympathetic tone.


Subject(s)
Dobutamine/therapeutic use , Heart Failure/drug therapy , Catecholamines/blood , Dose-Response Relationship, Drug , Heart Failure/physiopathology , Hemodynamics/drug effects , Humans , Middle Aged , Milrinone , Myocardial Contraction/drug effects , Pyridones/therapeutic use , Receptors, Adrenergic, beta/physiology
17.
J Am Coll Cardiol ; 11(2): 276-83, 1988 Feb.
Article in English | MEDLINE | ID: mdl-3339167

ABSTRACT

This study examined 65 patients with ventricular tachycardia or fibrillation late after myocardial infarction to determine whether they differed with respect to duration of ventricular activation in sinus rhythm and left ventricular ejection fraction. Patients with spontaneous ventricular tachycardia had a longer ventricular activation time in sinus rhythm than did patients with spontaneous ventricular fibrillation. This difference was detected with the signal-averaged electrocardiogram (ECG) (tachycardia 181 +/- 33 ms, fibrillation 152 +/- 23 ms, p less than 0.001) and at epicardial mapping (tachycardia 210 +/- 17 ms, fibrillation 192 +/- 17 ms, p less than 0.02). Left ventricular ejection fraction was lower in patients with spontaneous ventricular tachycardia (0.22 +/- 0.09) than in patients with spontaneous ventricular fibrillation (0.27 +/- 0.09) (p less than 0.05). The patients with both spontaneous and inducible ventricular fibrillation had a shorter ventricular activation time on the signal-averaged ECG (129 +/- 17 ms) and a higher ejection fraction (0.36 +/- 0.05) than did either patients with spontaneous ventricular fibrillation and inducible ventricular tachycardia (158 +/- 21 ms and 0.25 +/- 0.08, respectively, each p less than 0.01) or patients with both spontaneous and inducible ventricular tachycardia (181 +/- 33 ms and 0.22 +/- 0.09, respectively, each p less than 0.001). Of the patients with inducible ventricular tachycardia, presentation with tachycardia rather than fibrillation was associated with a longer ventricular activation time on the signal-averaged ECG (181 +/- 33 versus 158 +/- 21 ms, p less than 0.02) and a longer cycle length of inducible ventricular tachycardia (290 +/- 61 versus 259 +/- 44 ms, p = 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Electrocardiography , Heart/physiopathology , Tachycardia/physiopathology , Ventricular Fibrillation/physiopathology , Adult , Aged , Cardiac Pacing, Artificial , Electric Stimulation , Electrophysiology , Female , Heart Ventricles/diagnostic imaging , Humans , Male , Middle Aged , Myocardial Infarction/physiopathology , Pericardium/physiopathology , Radionuclide Imaging , Stroke Volume , Tachycardia/diagnostic imaging , Ventricular Fibrillation/diagnostic imaging
18.
J Am Coll Cardiol ; 11(1): 101-8, 1988 Jan.
Article in English | MEDLINE | ID: mdl-3335686

ABSTRACT

Spontaneous day to day variability in the mode of induction of ventricular tachycardia at programmed stimulation in the drug-free state has been described but not quantitated. To quantitate this variability, this study employed a new protocol of programmed stimulation in which the number of extrastimuli required for tachycardia induction was the only major stimulation variable. This protocol was applied to 18 consecutive patients with previously documented sustained ventricular tachyarrhythmia due to coronary artery disease. One to seven extrastimuli were available for arrhythmia induction if required. Each patient underwent programmed stimulation in the absence of antiarrhythmic drugs on 3 separate days with a mean interval of 5 +/- 2.7 days between studies. A sustained ventricular tachyarrhythmia was inducible in all studies with less than or equal to 4 extrastimuli; the mean number of extrastimuli required was 2.4 +/- 0.8. Day to day variability in the number of extrastimuli required for tachycardia induction was observed in the majority of patients (72%). Eleven patients (61%) varied by one extrastimulus over the three control studies, and two patients (11%) varied by two extrastimuli. At analysis of variance, the 95% confidence interval for the degree of day to day variability was +/- 1 extrastimulus from the mean number required in the three studies. Multiple configurations of induced ventricular tachycardia were frequently observed at repeat studies and occurred in 15 patients (83%). In conclusion, spontaneous day to day variability in mode of induction of ventricular tachycardia in the absence of drugs is common.(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Cardiac Pacing, Artificial , Heart Conduction System/physiopathology , Tachycardia/etiology , Anti-Arrhythmia Agents , Coronary Disease/physiopathology , Electrophysiology , Female , Humans , Male , Middle Aged , Tachycardia/physiopathology , Time Factors
19.
Am J Cardiol ; 60(7): 580-3, 1987 Sep 01.
Article in English | MEDLINE | ID: mdl-3630941

ABSTRACT

Repeat signal-averaged electrocardiograms were used in 40 patients to document changes in ventricular activation time and delayed potentials in the first 12 months after acute myocardial infarction. Beta-blocking and antiarrhythmic drug use was stopped for 1 week before each recording. Patients with reinfarction during follow-up were excluded. Signal-averaged electrocardiograms were first performed 1 to 4 weeks after infarction. They were repeated at 6 and 12 months in 31 patients in whom spontaneous ventricular tachycardia (VT) did not develop and were repeated after VT in the other 9 patients. Of the 9 patients in whom VT developed, all had delayed potentials at initial study and 8 (89%) still had delayed potentials at restudy after VT. In the VT patients, mean ventricular activation time was similar before and after VT (178 ms and 174 ms, respectively). In the 11 patients who had delayed potentials initially and in whom VT did not develop, the proportion with delayed potentials was 55% (6 of 11) at 6 months and did not change (55%) at 12 months. Mean ventricular activation time in these patients was 164 ms at initial study, decreasing to 147 ms at 6 months (p less than 0.05) and 148 ms at 12 months. In 20 patients with no delayed potentials initially, none had delayed potentials at 6 months and only 2 (10%) had delayed potentials detectable at 12 months. Mean ventricular activation time in these patients increased slightly, from 120 ms at initial study to 128 ms at 12 months (p less than 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Electrocardiography/methods , Heart Conduction System/physiopathology , Myocardial Infarction/complications , Signal Processing, Computer-Assisted , Tachycardia/etiology , Action Potentials , Electrophysiology , Humans , Middle Aged , Myocardial Infarction/physiopathology , Tachycardia/diagnosis , Time Factors
20.
Circulation ; 75(6 Pt 2): V25-33, 1987 Jun.
Article in English | MEDLINE | ID: mdl-3568337

ABSTRACT

This study examined whether combination therapy with allopurinol plus verapamil would enhance limitation of myocardial infarct size compared with either allopurinol or verapamil alone in closed-chest dogs subjected to 24 hr of permanent coronary occlusion. Four groups were studied: control, dogs receiving allopurinol (400 mg po 24 and 2 hr before coronary occlusion and 10 mg/kg iv 6 hr after occlusion), dogs receiving verapamil (200 micrograms/kg iv bolus, then continuous administration of 5 micrograms/kg/min), and dogs receiving allopurinol plus verapamil as indicated above. The anatomic risk zone and regional myocardial blood flow were measured with radioactive microspheres administered intraventricularly 1 min after coronary occlusion. Necrotic tissue was visualized by triphenyl tetrazolium chloride staining and the risk zone by autoradiography of the microspheres. Infarct size, expressed as a percentage of the risk zone, was 75.9 +/- 13.7% (mean +/- SD) in the control group, 44.1 +/- 13.3% in the allopurinol group (p less than .05 vs control), 40.6 +/- 11.1% in the verapamil group (p less than .05 vs control), and 37.9 +/- 13.6% in the allopurinol plus verapamil group (p less than .05 vs control; p = NS vs drug-treated groups). In controls, there was a close correlation (r = -.83) between infarct size and subepicardial collateral blood flow. As a result the expected infarct size in the treatment group that would have occurred without drug-treatment could be reliably predicted based on the correlation between infarct size and subepicardial collateral blood flow. The ratio of the actual and predicted infarct size provides a "salvage index".(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Allopurinol/therapeutic use , Myocardial Infarction/drug therapy , Verapamil/therapeutic use , Animals , Coronary Circulation/drug effects , Disease Models, Animal , Dogs , Drug Evaluation, Preclinical , Drug Therapy, Combination , Male , Myocardial Infarction/pathology , Myocardium/pathology , Risk , Time Factors
SELECTION OF CITATIONS
SEARCH DETAIL
...