Fundus topographical distribution patterns of ocular toxoplasmosis.

BACKGROUND: To establish topographic maps and determine fundus distribution patterns of ocular toxoplasmosis (OT) lesions. METHODS: In this retrospective study, patients who presented with OT to ophthalmology clinics from four countries (Argentina, Turkey, UK, USA) were included. Size, shape and location of primary (1°)/recurrent (2°) and active/inactive lesions were converted into a two-dimensional retinal chart by a retinal drawing software. A final contour map of the merged image charts was then created using a custom Matlab programme. Descriptive analyses were performed. RESULTS: 984 lesions in 514 eyes of 464 subjects (53% women) were included. Mean area of all 1° and 2° lesions was 5.96±12.26 and 5.21±12.77 mm2, respectively. For the subset group lesions (eyes with both 1° and 2° lesions), 1° lesions were significantly larger than 2° lesions (5.52±6.04 mm2 vs 4.09±8.90 mm2, p=0.038). Mean distances from foveola to 1° and 2° lesion centres were 6336±4267 and 5763±3491 µm, respectively. The majority of lesions were found in temporal quadrant (p<0.001). Maximum overlap of all lesions was at 278 µm inferotemporal to foveola. CONCLUSION: The 1° lesions were larger than 2° lesions. The 2° lesions were not significantly closer to fovea than 1° lesions. Temporal quadrant and macular region were found to be densely affected underlining the vision threatening nature of the disease.

Research into Glaucoma and Ethnicity (ReGAE) 8: is there a relationship between social deprivation and acute primary angle closure?

OBJECTIVES: Social deprivation as measured by the Index of Multiple Deprivation (IMD) and Townsend scores has been shown to be associated with advanced presentation of primary open angle glaucoma. The aim of this study was to investigate the putative association of social deprivation as a risk factor for acute primary angle closure (APAC) in a UK urban population. METHODS: Case notes of 139 consecutive patients presenting with APAC at the Birmingham and Midland Eye Centre, Birmingham, UK, were examined. Deprivation was scored using the IMD 2004 and Townsend scores. These score were compared with the West Midlands reference population. RESULTS: The level of deprivation in patients with APAC was graded according to the IMD quintiles, in which quintile 1 represents the highest level of deprivation and quintile 5 represents the lowest level of deprivation. Of the patients studied, 66.1% (n=90) were from quintiles 1 or 2 (most deprived) whereas 9% (n=12) came from quintile 5 (least deprived), compared with predicted frequencies of 40% and 20%, respectively. Deprivation levels measured by frequency within each IMD quintile were significantly higher in the APAC group compared with the reference population (χ(2), p<0.001). CONCLUSIONS: In this population patients presenting with APAC were more likely to come from areas with a high level of social deprivation.