ABSTRACT
We report a case of spontaneous clearance of hepatitis C virus (HCV) in a patient co-infected for 20 years with HCV and HIV, and with an chronic active hepatitis C never treated with anti-HCV regimens. We review the literature of eight anecdotal reports describing the spontaneous resolution of chronic HCV infection among HIV-infected patients, and discuss the virological, immunological, pathogenetic and therapeutic implications of this observation.
Subject(s)
HIV Infections/diagnosis , HIV Infections/pathology , Hepacivirus/isolation & purification , Hepatitis C, Chronic/diagnosis , Hepatitis C, Chronic/pathology , Hepatitis, Chronic/diagnosis , Hepatitis, Chronic/pathology , Coinfection/diagnosis , Coinfection/immunology , Coinfection/pathology , Coinfection/virology , HIV Infections/immunology , HIV Infections/virology , Hepatitis C, Chronic/immunology , Hepatitis C, Chronic/virology , Hepatitis, Chronic/immunology , Hepatitis, Chronic/virology , Humans , Male , Middle Aged , Viral LoadABSTRACT
A case of cervicofacial and pulmonary actinomycosis associated with non-Hodgkin's lymphoma (NHL) is reported. The patient underwent antimicrobial treatment and surgical debridement of a palatine lesion. Complete clinical recovery was achieved. The presence of actinomycosis may obscure and delay the diagnosis of NHL.
Subject(s)
Actinomycosis/complications , Lung Diseases/complications , Lymphoma, Non-Hodgkin/complications , Mouth Diseases/complications , Actinomycosis/diagnosis , Actinomycosis/therapy , Aged , Female , Humans , Lung Diseases/diagnosis , Lung Diseases/therapy , Mouth Diseases/diagnosis , Mouth Diseases/therapy , Palate/microbiologySubject(s)
Factor VIII/antagonists & inhibitors , Hepatitis, Viral, Human/blood , Aged , Aged, 80 and over , Female , HumansABSTRACT
By using abdominal ultrasonography (UlS), deep nodes were detected in 41 of 85 (48%) HIV-1 positive subjects, most of them heroin addicts, but in none of 85 healthy HIV-negative controls. Computerized tomography, performed in 10 cases of lymphadenopathy, invariably confirmed the UlS findings. Prevalence [asymptomatic carriers: 8/15 (53%); PGL patients: 8/18 (44%); ARC: 13/27 (48%); AIDS: 12/25 (48%)], number, size, and site of deep nodes were comparable among the different CDC groups. No correlation was found between abdominal and superficial lymphadenopathy. Median serum concentrations of gammaglobulins (g/dl) and IgG (mg/dl) were higher in patients with than without deep nodes (2.25 vs 1.87 and 2540 vs 1900, respectively) (p < 0.01) as well as in cases with than without superficial nodes (2.15 vs 1.80 and 2340 vs 1941, respectively) (p < 0.05). Abdominal lymphadenopathy occurred during all stages of HIV infection even in asymptomatic carriers: this should be considered in the differential diagnosis of UlS-detected deep nodes. Enlargement of either deep or superficial nodes seems to reflect a state of polyclonal B cell activation.
