Subject(s)
Cell Biology/standards , Early Detection of Cancer/standards , Laboratories/standards , Mass Screening/standards , Practice Guidelines as Topic , Uterine Cervical Neoplasms/diagnosis , Alphapapillomavirus/isolation & purification , Automation, Laboratory/standards , Cell Biology/organization & administration , Cervix Uteri/pathology , Cervix Uteri/virology , Colposcopy/methods , Female , Humans , Information Storage and Retrieval/legislation & jurisprudence , Information Storage and Retrieval/standards , Laboratories/organization & administration , Medical Audit , Medical Laboratory Personnel/education , Medical Laboratory Personnel/organization & administration , Medical Laboratory Personnel/standards , Specimen Handling/standards , United Kingdom , Uterine Cervical Neoplasms/virology , WorkforceABSTRACT
The BSCC terminology was originally published in 1986 and although highly successful, requires revision. Through a process of professional consensus and literature review this has been undertaken by the BSCC. The revision takes account of recent developments and improvements in understanding of morphology and disease process and is compatible with other terminologies in use elsewhere, whilst still maintaining a focus on practice in the UK cervical screening programmes.
Subject(s)
Uterine Cervical Dysplasia/classification , Uterine Cervical Neoplasms/classification , Female , Humans , Terminology as Topic , Uterine Cervical Dysplasia/diagnosis , Uterine Cervical Neoplasms/diagnosis , Vaginal SmearsSubject(s)
Cytological Techniques , Uterine Cervical Diseases/diagnosis , Cytological Techniques/statistics & numerical data , Female , Humans , Mass Screening/methods , Sensitivity and Specificity , Time Factors , United Kingdom , Uterine Cervical Diseases/classification , Uterine Cervical Diseases/pathologySubject(s)
Cell Biology/education , Education, Medical, Graduate/trends , Pathology, Clinical/education , Uterine Cervical Neoplasms/diagnosis , Vaginal Smears , Education, Medical, Graduate/organization & administration , Female , Forecasting , Humans , Pathology, Clinical/organization & administration , Pathology, Clinical/trendsABSTRACT
Adhesion molecules are substances which are involved in the interactions between cells, and between cells and the extracellular matrix in both benign and malignant tissues. Two members of this group--intercellular adhesion molecule-1 (ICAM-1) and MUC18--have previously been found to be expressed on melanoma; however, studies seeking a correlation between expression and metastatic behaviour have yielded conflicting results. In this study we investigated the expression of these two antigens and that of a number of other adhesion molecules [VCAM-1, ELAM, and the neural cell adhesion molecule (NCAM)] on a range of benign and malignant melanocytic lesions. Both ICAM-1 and MUC18 were found on a high percentage of all melanocytic lesions including benign naevi. VCAM-1 was found to be expressed on 79 per cent of benign naevi, 62 per cent of primary melanomas less than 1.5 mm in depth, and 6 per cent of thick primaries. The antigen was present on 14 per cent of lymph node metastases and on no extranodal deposits. This suggests that loss of melanoma cell adhesion mediated by VCAM-1 may be important in the development of metastatic melanoma.
Subject(s)
Biomarkers, Tumor/immunology , Cell Adhesion Molecules/immunology , Melanoma/immunology , Neural Cell Adhesion Molecules , Antigens, CD/analysis , CD146 Antigen , Cell Adhesion Molecules/analysis , Cell Adhesion Molecules, Neuronal/analysis , Humans , Immunohistochemistry , Intercellular Adhesion Molecule-1 , Leukocyte L1 Antigen Complex , Melanoma/chemistry , Membrane Glycoproteins/analysis , Neoplasm Metastasis , Nevus/chemistry , Nevus/immunology , Vascular Cell Adhesion Molecule-1ABSTRACT
Members of the genus Campylobacter are well recognised as enteric pathogens but have rarely been implicated as human placental pathogens. A case of septic abortion due to C jejuni is reported. This occurred in a previously healthy woman with a diarrhoeal illness. The presence of chorioamnionitis raises the possibility of ascending infection rather than septicaemic spread as the pathogenesis. Members of the genus Campylobacter have special culture requirements and their incidence as placental pathogens may therefore be underestimated.
Subject(s)
Campylobacter Infections/complications , Campylobacter jejuni/pathogenicity , Placenta Diseases/etiology , Abortion, Septic/etiology , Adult , Chorioamnionitis/etiology , Diarrhea/etiology , Female , Humans , PregnancySubject(s)
Breast Neoplasms/diagnosis , Melanoma/diagnosis , Paget's Disease, Mammary/diagnosis , Breast Neoplasms/pathology , Carcinoma in Situ/diagnosis , Carcinoma in Situ/pathology , Carcinoma, Intraductal, Noninfiltrating/diagnosis , Carcinoma, Intraductal, Noninfiltrating/pathology , Humans , Male , Melanoma/pathology , Middle Aged , Neoplasms, Multiple Primary/diagnosis , Neoplasms, Multiple Primary/pathology , Paget's Disease, Mammary/pathologyABSTRACT
The distribution of factor XIIIa-positive dermal dendritic cells was studied in a series of nodular malignant melanomas and compared with that seen in Spitz naevi. Two patterns of distribution were recognizable: (a) diffusely spread through the tumour and (b) located mainly at the periphery of the tumour. These did not correlate with the diagnosis of melanoma or Spitz naevus and the distribution appeared to be a function of growth pattern of the tumour. The diffuse pattern was the most common regardless of diagnosis and the distribution of factor XIIIa-positive cells is the same in malignant melanoma and Spitz naevi.
