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1.
Int J Cardiovasc Imaging ; 22(5): 605-13, 2006 Oct.
Article in English | MEDLINE | ID: mdl-16649074

ABSTRACT

Serial intravascular ultrasound (IVUS) measurements of coronary vessel dimensions are major endpoints of studies focusing on pharmacological interventions, efficiency of drug eluting stents, and vascular remodeling. In serial studies measurement variability among different IVUS devices may cause substantial misinterpretation and error. We analyzed 33 human coronary plaques in vitro using two different IVUS systems (mechanical IVUS system with a 40 MHz Atlantis SR catheter; solid-state electronic IVUS system with a 20 MHz Invision catheter) and repeatedly measured the total vessel, lumen, and plaque + media cross-sectional area and plaque burden (plaque + media area divided by total vessel area). Between the "raw" measurements made by the two devices, there was a significant difference for both plaque + media area (2.35+/-1.86 mm(2), P < 0.01) and plaque burden (5.39+/-3.68%, P < 0.05). Measurements were then corrected by use of recently introduced calibration formulas; as a result the differences decreased significantly for all IVUS parameters measured ( P < 0.0001). After correction, the remaining differences between the corrected mechanical and solid-state IVUS measurements similar to differences between repeated measurements with the same IVUS device (i.e., the intraobserver variability). Thus, in serial studies the use of different IVUS devices at index and follow-up procedure may introduce a substantial error as a result of system-related differences. The application of dedicated calibration formulas allows for correction for these differences by decreasing such differences to the level of intraobserver variability.


Subject(s)
Coronary Artery Disease/diagnostic imaging , Coronary Vessels/diagnostic imaging , Image Interpretation, Computer-Assisted/methods , Ultrasonography, Interventional/instrumentation , Aged , Calibration , Clinical Trials as Topic , Female , Humans , In Vitro Techniques , Linear Models , Male , Observer Variation , Reproducibility of Results , Research Design
2.
Circulation ; 110(12): 1579-85, 2004 Sep 21.
Article in English | MEDLINE | ID: mdl-15364814

ABSTRACT

BACKGROUND: Intravascular ultrasound (IVUS) is increasingly used as an end point in studies aimed at reducing progression or inducing regression of coronary artery disease. However, data linking serial changes by IVUS with clinical outcomes are scarce. METHODS AND RESULTS: In the absence of a validated risk score for secondary prevention, we compared 3 established risk scores for primary prevention--PROCAM, SCORE, and Framingham--with plaque progression and lumen reduction as assessed with serial IVUS (follow-up, 18+/-9 months) in atherosclerotic left main coronary arteries of 56 patients with established atherosclerosis. For all 3 algorithms, patients at highest estimated risk of events showed greater plaque progression than patients at lowest risk (P<0.05 to <0.01). There were positive linear relationships between the risk of clinical events and plaque progression (r=0.41 to 0.60; P<0.002 to <0.0001). This translated into a greater decrease in lumen dimensions with increasing risk (P<0.05, PROCAM and SCORE). Risk prediction using the PROCAM algorithm showed the strongest relation with serial IVUS. During follow-up, 18 patients suffered from adverse cardiovascular events; these patients had an annual plaque progression that was significantly greater than other patients (25.2+/-19.4% versus 5.9+/-15.6%, P<0.001). CONCLUSIONS: There was a positive linear relationship between the estimated risk of clinical events derived from all 3 established risk-score algorithms and the extent of plaque progression measured by serial IVUS. This translated into stenosis progression (reduction in lumen dimensions) with increasing clinical risk.


Subject(s)
Angina, Unstable/epidemiology , Coronary Artery Disease/diagnostic imaging , Coronary Vessels/diagnostic imaging , Myocardial Infarction/epidemiology , Ultrasonography, Interventional , Aged , Algorithms , Angioplasty, Balloon, Coronary , Comorbidity , Coronary Artery Disease/pathology , Coronary Vessels/pathology , Disease Progression , Female , Follow-Up Studies , Humans , Hyperlipidemias/epidemiology , Male , Metabolic Syndrome/epidemiology , Middle Aged , Risk , Risk Assessment/methods , Severity of Illness Index , Smoking/epidemiology , Treatment Outcome
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