ABSTRACT
Release of acetylcholine (ACh) to the lateral brain ventricle of non-anaesthetised rats was investigated 24 h after intraperitoneal administration of neuroleptics or simultaneous administration of clonidine or apomorphine given subcutaneously. The only significant observed effect was an increase of ACh release by clozapine.
Subject(s)
Acetylcholine/metabolism , Antipsychotic Agents/pharmacology , Cerebral Ventricles/metabolism , Animals , Apomorphine/pharmacology , Clonidine/pharmacology , Male , Physostigmine/pharmacology , Rats , Rats, Inbred StrainsABSTRACT
The effect of some cholinolytics, cholinomimetics and atypical antidepressants on behavior of rats forced to swim (in the "behavioral despair test") was investigated. In addition, the relation between the test performance and the inborn level of exploratory and locomotor activities was studied. Cholinomimetics prolonged, while cholinolytics and antidepressants shortened the immobility phase ("despair reaction"). The "despair reaction" was less pronounced in rats with high motor exploratory activity level.
Subject(s)
Antidepressive Agents/pharmacology , Behavior, Animal/drug effects , Motor Activity/drug effects , Parasympatholytics/pharmacology , Parasympathomimetics/pharmacology , Animals , Male , Rats , Rats, Inbred Strains , Swimming , Time FactorsABSTRACT
Rats were treated ip with MAO inhibitos (MAO-I): nialamid (NL), pivalylbenzylhydrazine, tranylcypromine, pheniprazine (Ph) or pargyline, and the leve of total, free and bound acetylcholine (Ach) as well as the acetylcholinesterase (Ach-E) activity were estimated in four parts of rats brain 2 or 16 hr after the treatment. These parameters were estimated also after the treatment with tricyclic antidepressants: desmethylimipramine (DMI), amitriptyline, or protriptiline, and in the conditions of the reversal of reserpine-like syndrom. MAO-I, 2 hr after their application and the reversal of reserpine like-syndrom have not changed the level of measured fractions of Ach in parts of the brain. DMI increased the level of all Ach fractions in the striatum. NL caused the decrease of bound Ach level in all parts of the brain with no changes of free Ach level, 16 hr after the treatment. Ph, 16 hr after the treatment, decrease both fractions of ACh only in the cortex. All studied drugs affected evidently ACh-E activity in various parts of brain. It is concluded that:1) Cholinergic mechanisms in the rat brain are involved in the central action of DMI and of some MAO-I., 3) Cholinergic function of the brain may be modulated by the adrenergic activity, 2) Individual parts of the brain have different susceptibility to the influence of different MAO-I on the ACh-E activity.
Subject(s)
Acetylcholine/analysis , Acetylcholinesterase/metabolism , Antidepressive Agents/pharmacology , Brain Chemistry/drug effects , Brain/enzymology , Animals , Antidepressive Agents, Tricyclic/pharmacology , Monoamine Oxidase Inhibitors/pharmacology , Rats , Reserpine/antagonists & inhibitors , Time FactorsSubject(s)
Acetylcholine/metabolism , Antipsychotic Agents/pharmacology , Behavior, Animal/drug effects , Brain/metabolism , Animals , Benperidol/pharmacology , Chlorpromazine/pharmacology , Exploratory Behavior/drug effects , Male , Methotrimeprazine/pharmacology , Phenothiazines/pharmacology , Rats , Reserpine/pharmacology , Thiothixene/pharmacologyABSTRACT
Acetylcholine content in the brain and heart of developing rats. Acta Physiol. Pol. 1975, 26 (1): 41-44. The content of acetylcholine was determined in four parts of the brain and in the heart of developing rats. It was found that changes in acetylcholine level were not parallel in the examined brain stuctures and in the heart in the time period from birth to 18 months of age of the rats.
