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1.
Am J Clin Pathol ; 116(1): 92-6, 2001 Jul.
Article in English | MEDLINE | ID: mdl-11447758

ABSTRACT

We reviewed the results of all breast core needle biopsies with a diagnosis of atypical ductal hyperplasia (ADH) or atypia not otherwise specified and subsequent excisional biopsies for a 50-month period and correlated the results. Of 3,026 biopsies, 216 were diagnosed as ADH or atypia not otherwise specified, and subsequent resection was available for 105. After review, 95 qualified as ADH. Subsequent resection showed ductal carcinoma in situ (DCIS) in 13 excisions, ADH in 31, lobular carcinoma in situ in 6, and benign proliferative lesions in the remaining 45. In none of the 8 biopsies in which DCIS was found and radiographs were available for review was the radiographic lesion entirely removed. For comparison, the incidence of carcinoma in resections done for a diagnosis of DCIS, low or intermediate grade (solid, cribriform, or micropapillary type), on core needle biopsy was significantly greater (8 of 10 cases). However, the size of the lesions diagnosed as carcinoma also was significantly greater than that of the lesions diagnosed as ADH, and in none of the 8 biopsies with DCIS at excision was the lesion entirely removed at the time of biopsy. The incidence of carcinoma in excisional biopsies done for a diagnosis of ADH in core needle biopsies in our institution is relatively low, while the incidence of ADH is relatively high. Possible reasons for this include total removal of small lesions at the time of biopsy and use of the diagnostic term ADH for lesions that are not associated with coexistent DCIS.


Subject(s)
Biopsy, Needle , Breast/pathology , Adult , Aged , Aged, 80 and over , Breast/surgery , Breast Neoplasms/epidemiology , Breast Neoplasms/pathology , Breast Neoplasms/surgery , Carcinoma in Situ/pathology , Carcinoma in Situ/surgery , Carcinoma, Ductal, Breast/pathology , Carcinoma, Ductal, Breast/surgery , Female , Florida , Follow-Up Studies , Humans , Hyperplasia/epidemiology , Incidence , Mammography , Middle Aged
3.
Health Psychol ; 18(2): 159-68, 1999 Mar.
Article in English | MEDLINE | ID: mdl-10194051

ABSTRACT

Much work on psychosocial sequelae of breast cancer has been guided by the assumption that body image and partner reaction issues are focal. In a tri-ethnic sample of 223 women treated for early-stage breast cancer within the prior year, the authors assessed a wider range of concerns and relations to well-being. Strongest concerns were recurrence, pain, death, harm from adjuvant treatment, and bills. Body-image concerns were moderate; concern about rejection was minimal. Younger women had stronger sexual and partner-related concerns than older women. Hispanic women had many stronger concerns and more disruption than other women. Life and pain concerns and sexuality concerns contributed uniquely to predicting emotional and psychosexual disruption; life and pain concerns and rejection concerns contributed to predicting social disruption. In sum, adaptation to breast cancer is a process bearing on several aspects of the patient's life space.


Subject(s)
Adaptation, Psychological , Breast Neoplasms/psychology , Ethnicity/psychology , Sick Role , Social Adjustment , Adult , Aged , Aged, 80 and over , Anxiety/psychology , Body Image , Breast Neoplasms/pathology , Cross-Cultural Comparison , Female , Gender Identity , Humans , Middle Aged , Neoplasm Staging , Quality of Life
4.
Psychosom Med ; 60(2): 168-74, 1998.
Article in English | MEDLINE | ID: mdl-9560865

ABSTRACT

OBJECTIVE: Several authors have suggested that patients adjust more poorly to breast cancer if they are heavily invested in body image as a source of their sense of self-worth. This prospective study examined this possibility, looking at two aspects of concern about body image as predictors of several indices of adjustment over the first postoperative year. METHODS: At diagnosis (and again a year later) 66 women with early stage breast cancer reported how much they valued a) a sense of body integrity (or intactness) and b) a good physical appearance. The day before surgery, a week afterward, and at 3-month, 6-month, and 12-month follow ups, they reported on their mood. At presurgery and at follow ups they also rated their attractiveness and sexual desirability and reported on frequency of sexual interaction. At follow-ups they also indicated how much their illness and treatment were interfering with social and recreational activities. RESULTS: Initial investment in appearance was related to distress across the postsurgical year. In contrast, investment in appearance made women more resilient against deterioration in their perceptions of attractiveness. Concern about body integrity did not strongly predict emotional distress, but it related to adverse impact on social and recreational activities in the follow-up period, to deterioration in feelings of sexual desirability, and to feelings of alienation from the self (feeling "not like yourself anymore"). CONCLUSIONS: Body image is often thought of in terms of physical appearance, but there is also a body image pertaining to integrity, wholeness, and normal functioning. People who are greatly concerned about either aspect of their body image are vulnerable to poorer psychosocial adjustment when confronting treatment for breast cancer. The poorer adjustment takes a different form, however, depending on the nature of the patient's body-image concern.


Subject(s)
Adaptation, Psychological , Body Image , Breast Neoplasms/psychology , Social Adjustment , Adult , Aged , Attitude to Health , Breast Neoplasms/therapy , Cost of Illness , Female , Humans , Middle Aged , Neoplasm Staging , Prospective Studies , Regression Analysis , Self Concept
5.
Ann Plast Surg ; 3(4): 326-9, 1979 Oct.
Article in English | MEDLINE | ID: mdl-231919

ABSTRACT

The incidence of locally recurrent carcinoma after mastectomy is low--between 6 and 20%. Recent case histories of 4 patients who were clinically free of breast carcinoma and who developed local recurrence after reconstruction are reviewed. Possible relationships of breast reconstruction to local recurrence are discussed. The development of capsule formation in the reconstructed breast may denote recurrent disease.


Subject(s)
Breast Neoplasms/surgery , Neoplasm Recurrence, Local/etiology , Postoperative Complications , Surgery, Plastic , Breast Neoplasms/etiology , Breast Neoplasms/pathology , Carcinoma, Intraductal, Noninfiltrating/etiology , Carcinoma, Intraductal, Noninfiltrating/pathology , Carcinoma, Intraductal, Noninfiltrating/surgery , Female , Humans , Mastectomy , Middle Aged , Neoplasm Recurrence, Local/pathology , Prostheses and Implants/adverse effects , Silicone Elastomers/adverse effects
6.
JAMA ; 241(21): 2264, 1979 May 25.
Article in English | MEDLINE | ID: mdl-439291
7.
JAMA ; 240(4): 374-5, 1978 Jul 28.
Article in English | MEDLINE | ID: mdl-660874

ABSTRACT

Tumor recurrence after a prolonged disease-free interval suggests that neoplastic cells may remain dormant within the host. Activation and growth of these metastatic focuses may occur secondary to inflammation at sites distant from the primary tumor. The concept of inflammatory oncotaxis is presented as a mechanism of cancer cell attraction and facilitation of transcapillary migration into tissue spaces. Physicians should focus astutely on internal and external sites of inflammation as possible focuses for tumor recurrence in the follow-up of the cancer patient.


Subject(s)
Inflammation , Neoplasm Metastasis , Neoplasms , Neoplastic Cells, Circulating , Aged , Female , Humans , Inflammation/pathology , Male , Middle Aged , Neoplasms/pathology , Neoplasms/surgery , Recurrence , Time Factors , Wounds and Injuries
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